Beta-arrestin-2 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR84 74.4
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Aromatic TM6 F 314 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 F 314 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 F 314 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 R 118 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 118 3x50 s5s6 L 72 N.s5s6.08
Aromatic TM6 F 314 6x30 S6 F 76 N.S6.01
Hydrophobic TM6 F 314 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 F 314 6x30 S6 F 76 N.S6.01
Hydrophobic TM5 A 211 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 A 211 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 P 125 34x50 S16 A 248 C.S16.01
Hydrophobic TM5 L 212 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 212 5x72 S6 K 78 N.S6.03
Polar TM3 A 123 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 123 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 A 123 3x55 s15s16 S 246 C.s15s16.04
Polar TM3 I 122 3x54 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 122 3x54 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 I 122 3x54 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 K 216 5x76 S6 L 80 N.S6.05
Van-der-waals TM5 K 216 5x76 S6 L 80 N.S6.05
Hydrophobic ICL2 K 126 34x51 S16 A 248 C.S16.01
Ionic TM2 R 54 2x38 s8s9 E 135 N.s8s9.05
Polar TM2 R 54 2x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 R 54 2x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 R 54 2x38 s8s9 E 135 N.s8s9.05
Polar H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 374 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 F 314 6x30 S6 K 78 N.S6.03
Ionic ICL3 R 305 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 305 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 305 - s9s10 E 156 N.s9s10.07
Polar TM3 L 121 3x53 S5 Y 64 N.S5.12
Hydrophobic TM3 L 121 3x53 S5 Y 64 N.S5.12
Van-der-waals TM3 L 121 3x53 S5 Y 64 N.S5.12
Hydrophobic TM6 M 320 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 320 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 121 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 121 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 I 59 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 N 56 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 56 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 212 5x72 S6 L 80 N.S6.05
Van-der-waals TM5 L 212 5x72 S6 L 80 N.S6.05
Hydrophobic TM5 Y 215 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 Y 215 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 Y 215 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 Y 215 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic H8 F 377 8x50 s5s6 V 71 N.s5s6.07
Polar TM5 A 211 5x71 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 A 211 5x71 s17s18 N 312 C.s17s18.37
Hydrophobic TM6 V 317 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 I 122 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 205 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 V 205 5x65 S6 F 76 N.S6.01
Hydrophobic TM3 I 122 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 122 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 125 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 125 34x50 s15s16 S 246 C.s15s16.04
Polar TM5 K 216 5x76 S6 D 79 N.S6.04
Van-der-waals TM5 K 216 5x76 S6 D 79 N.S6.04
Hydrophobic TM2 F 55 2x39 s5s6 V 71 N.s5s6.07
Polar H8 Q 376 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 Q 376 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 Q 376 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 P 125 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 125 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 I 114 3x46 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 Y 370 7x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 208 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 208 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 P 308 6x24 S6 I 82 N.S6.07
Polar H8 N 374 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 N 374 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 374 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 V 317 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 317 6x33 s5s6 L 74 N.s5s6.10
Polar TM5 Y 215 5x75 s7s8 N 123 N.s7s8.05
Van-der-waals TM5 Y 215 5x75 s7s8 N 123 N.s7s8.05
Hydrophobic TM6 S 310 6x26 S6 K 78 N.S6.03
Hydrophobic ICL3 A 307 - S6 I 82 N.S6.07
Polar TM5 Q 204 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 204 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 R 118 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 V 317 6x33 S6 F 76 N.S6.01
Hydrophobic TM2 I 59 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 59 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 212 5x72 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 L 212 5x72 s17s18 V 315 C.s17s18.40
Polar TM5 A 208 5x68 S6 K 78 N.S6.03
Hydrophobic TM5 A 208 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 A 208 5x68 S6 K 78 N.S6.03
Aromatic ICL2 K 126 34x51 S16 Y 250 C.S16.03
Polar ICL2 K 126 34x51 S16 Q 249 C.S16.02
Hydrophobic ICL2 K 126 34x51 S16 Q 249 C.S16.02
Van-der-waals ICL2 K 126 34x51 S16 Q 249 C.S16.02
Polar TM2 T 53 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 53 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 53 2x37 s5s6 D 68 N.s5s6.04
Polar ICL3 Q 219 - s7s8 N 123 N.s7s8.05
Hydrophobic ICL3 Q 219 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 Q 219 - s7s8 N 123 N.s7s8.05