Arrestin-C - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR84 73.9
Arrestin-C 80.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 128 34x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 A 307 - S6 V 77 N.S6.07
Van-der-waals ICL3 A 307 - S6 V 77 N.S6.07
Polar TM3 R 118 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 118 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals ICL2 P 125 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL3 H 223 - s17s18 G 306 C.s17s18.35
Van-der-waals ICL3 H 223 - s17s18 G 306 C.s17s18.35
Hydrophobic TM3 R 118 3x50 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 R 118 3x50 s5s6 L 69 N.s5s6.10
Polar ICL2 K 126 34x51 s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 K 50 12x49 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 K 50 12x49 s5s6 V 66 N.s5s6.07
Polar ICL2 K 126 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 K 126 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 K 126 34x51 s8s9 A 133 N.s8s9.07
Ionic ICL2 K 126 34x51 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 K 126 34x51 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 K 126 34x51 s8s9 D 132 N.s8s9.06
Hydrophobic ICL1 K 50 12x49 s9s10 K 157 N.s9s10.12
Van-der-waals ICL1 K 50 12x49 s9s10 K 157 N.s9s10.12
Hydrophobic TM2 N 56 2x40 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 N 56 2x40 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 121 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 121 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 V 317 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 V 317 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 L 121 3x53 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 L 121 3x53 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 129 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 L 121 3x53 S6 F 71 N.S6.01
Polar TM6 S 310 6x26 S6 K 73 N.S6.03
Hydrophobic TM6 S 310 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 S 310 6x26 S6 K 73 N.S6.03
Hydrophobic TM3 I 122 3x54 S6 F 71 N.S6.01
Van-der-waals H8 Q 376 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 P 49 12x48 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 P 49 12x48 s5s6 V 66 N.s5s6.07
Polar TM5 L 212 5x72 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 L 212 5x72 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 L 212 5x72 s17s18 E 310 C.s17s18.39
Polar TM5 Y 215 5x75 s17s18 M 307 C.s17s18.36
Van-der-waals TM5 Y 215 5x75 s17s18 M 307 C.s17s18.36
Polar TM6 S 310 6x26 S6 R 72 N.S6.02
Hydrophobic TM6 S 310 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 S 310 6x26 S6 R 72 N.S6.02
Ionic ICL3 R 305 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 305 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 P 125 34x50 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 P 125 34x50 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 P 125 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 R 52 12x51 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 T 53 2x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 T 53 2x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 F 55 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 F 55 2x39 s5s6 I 67 N.s5s6.08
Polar H8 R 375 8x48 s9s10 T 154 N.s9s10.09
Hydrophobic H8 R 375 8x48 s9s10 T 154 N.s9s10.09
Van-der-waals H8 R 375 8x48 s9s10 T 154 N.s9s10.09
Polar H8 Q 376 8x49 s5s6 G 68 N.s5s6.09
Hydrophobic H8 Q 376 8x49 s5s6 G 68 N.s5s6.09
Van-der-waals H8 Q 376 8x49 s5s6 G 68 N.s5s6.09
Polar ICL3 Q 219 - s17s18 G 306 C.s17s18.35
Hydrophobic ICL3 Q 219 - s17s18 G 306 C.s17s18.35
Van-der-waals ICL3 Q 219 - s17s18 G 306 C.s17s18.35
Polar ICL3 Q 219 - s17s18 M 307 C.s17s18.36
Hydrophobic ICL3 Q 219 - s17s18 M 307 C.s17s18.36
Van-der-waals ICL3 Q 219 - s17s18 M 307 C.s17s18.36
Hydrophobic TM2 T 53 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 53 2x37 s5s6 V 66 N.s5s6.07
Polar TM6 S 310 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Y 215 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 Y 215 5x75 s17s18 D 308 C.s17s18.37
Polar ICL1 L 51 12x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 L 51 12x50 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 L 51 12x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 Y 215 5x75 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 Y 215 5x75 s17s18 E 310 C.s17s18.39
Polar H8 Q 376 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 376 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 T 53 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 53 2x37 s5s6 D 63 N.s5s6.04
Polar ICL3 Q 219 - s17s18 D 308 C.s17s18.37
Hydrophobic ICL3 Q 219 - s17s18 D 308 C.s17s18.37
Van-der-waals ICL3 Q 219 - s17s18 D 308 C.s17s18.37
Polar TM3 L 121 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 L 121 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 L 121 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 F 314 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 F 314 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 125 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic ICL3 A 307 - S6 D 74 N.S6.04
Van-der-waals ICL3 A 307 - S6 D 74 N.S6.04
Aromatic TM6 F 314 6x30 S6 F 71 N.S6.01
Hydrophobic TM6 F 314 6x30 S6 F 71 N.S6.01
Van-der-waals TM6 F 314 6x30 S6 F 71 N.S6.01
Hydrophobic TM5 A 211 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 A 211 5x71 s17s18 E 310 C.s17s18.39
Polar TM2 N 56 2x40 s5s6 V 66 N.s5s6.07
Polar TM5 Y 215 5x75 s17s18 K 309 C.s17s18.38
Hydrophobic TM5 Y 215 5x75 s17s18 K 309 C.s17s18.38
Van-der-waals TM5 Y 215 5x75 s17s18 K 309 C.s17s18.38