Beta-arrestin-2 - GPR87 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR87 72.9
Beta-arrestin-2 78.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 Y 232 5x64 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 Y 232 5x64 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 Y 232 5x64 s15s16 S 246 C.s15s16.04
Ionic C-term E 336 - s9s10 K 158 N.s9s10.09
Polar C-term E 336 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term E 336 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term E 336 - s9s10 K 158 N.s9s10.09
Ionic ICL1 R 71 - s20c D 402 C.s20c.12
Aromatic ICL2 Y 153 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 153 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 153 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 F 240 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 F 240 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 147 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 F 147 34x51 S8 L 130 N.S8.03
Hydrophobic H8 S 320 8x49 s20c C 409 C.s20c.19
Van-der-waals H8 S 320 8x49 s20c C 409 C.s20c.19
Hydrophobic TM7 M 317 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 M 317 7x56 s5s6 V 71 N.s5s6.07
Polar ICL1 K 73 - s20c Q 407 C.s20c.17
Van-der-waals ICL1 K 73 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 Y 153 34x57 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 Y 153 34x57 s8s9 E 135 N.s8s9.05
Polar TM4 I 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 I 155 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 I 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 F 240 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 240 - S6 K 78 N.S6.03
Polar C-term S 347 - S6 R 77 N.S6.02
Hydrophobic C-term S 347 - S6 R 77 N.S6.02
Van-der-waals C-term S 347 - S6 R 77 N.S6.02
Polar C-term R 346 - s9s10 L 155 N.s9s10.03
Ionic TM3 K 142 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 K 142 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 142 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 142 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals C-term E 348 - S6 R 77 N.S6.02
Polar TM5 Y 232 5x64 S5 Y 64 N.S5.12
Van-der-waals TM5 Y 232 5x64 S5 Y 64 N.S5.12
Aromatic ICL2 F 147 34x51 s5s6 R 66 N.s5s6.02
Ionic ICL1 K 73 - s20c D 402 C.s20c.12
Polar ICL1 K 73 - s20c D 402 C.s20c.12
Hydrophobic ICL1 K 73 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 73 - s20c D 402 C.s20c.12
Polar C-term S 347 - S6 D 79 N.S6.04
Polar ICL3 Q 239 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term V 349 - S6 D 79 N.S6.04
Van-der-waals C-term V 349 - S6 D 79 N.S6.04
Polar ICL2 Y 153 34x57 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Y 153 34x57 s17s18 R 286 C.s17s18.11
Polar ICL2 P 146 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 146 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 146 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic C-term I 351 - S6 K 78 N.S6.03
Hydrophobic H8 R 319 8x48 s20c C 409 C.s20c.19
Hydrophobic TM3 V 143 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 143 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 F 147 34x51 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 F 147 34x51 s8s9 A 140 N.s8s9.10
Hydrophobic C-term V 349 - S6 I 82 N.S6.07
Hydrophobic ICL1 K 73 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 73 - s8s9 T 137 N.s8s9.07
Hydrophobic H8 R 319 8x48 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 319 8x48 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 F 316 7x55 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 F 316 7x55 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 S 253 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic C-term R 350 - S6 K 78 N.S6.03
Van-der-waals C-term R 350 - S6 K 78 N.S6.03
Hydrophobic H8 C 318 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 147 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 F 147 34x51 S9 C 141 N.S9.01
Hydrophobic C-term Y 352 - s15s16 L 244 C.s15s16.02
Hydrophobic TM3 V 143 3x54 s5s6 L 72 N.s5s6.08
Polar TM6 S 253 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 S 253 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 253 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 233 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 233 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 146 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 146 34x50 S5 Y 64 N.S5.12
Polar TM4 S 154 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 S 154 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 154 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 73 - s8s9 E 135 N.s8s9.05
Hydrophobic C-term V 344 - s5s6 D 70 N.s5s6.06
Van-der-waals C-term V 344 - s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 F 147 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 147 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 F 147 34x51 s17s18 G 287 C.s17s18.12
Aromatic ICL3 F 240 - S6 F 76 N.S6.01
Hydrophobic ICL3 F 240 - S6 F 76 N.S6.01
Van-der-waals ICL3 F 240 - S6 F 76 N.S6.01
Hydrophobic C-term Y 352 - s17s18 V 315 C.s17s18.40
Van-der-waals C-term Y 352 - s17s18 V 315 C.s17s18.40
Aromatic ICL2 F 147 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 147 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 147 34x51 S16 Y 250 C.S16.03
Van-der-waals TM6 H 250 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 K 142 3x53 s5s6 R 66 N.s5s6.02
Polar H8 R 323 8x52 s20c L 408 C.s20c.18
Hydrophobic H8 R 323 8x52 s20c L 408 C.s20c.18
Van-der-waals H8 R 323 8x52 s20c L 408 C.s20c.18
Hydrophobic TM3 V 143 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 143 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic C-term Y 352 - S6 K 78 N.S6.03
Van-der-waals C-term Y 352 - S6 K 78 N.S6.03
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Ionic H8 R 319 8x48 s5s6 D 70 N.s5s6.06
Polar H8 R 319 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 319 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 319 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 K 142 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 K 142 3x53 s5s6 L 69 N.s5s6.05
Polar TM5 S 236 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 S 236 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 236 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Y 232 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Y 232 5x64 s15s16 F 245 C.s15s16.03
Polar TM6 H 250 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 H 250 6x33 s5s6 G 73 N.s5s6.09
Polar C-term Y 352 - s17s18 N 312 C.s17s18.37
Hydrophobic C-term Y 352 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term Y 352 - s17s18 N 312 C.s17s18.37
Polar TM2 T 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 74 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 F 240 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 F 240 - s15s16 L 244 C.s15s16.02
Hydrophobic C-term R 350 - S6 F 76 N.S6.01
Polar C-term Y 352 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term Y 352 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term Y 352 - s17s18 E 314 C.s17s18.39