S-arrestin - GPR87 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR87 71.4
S-arrestin 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 R 246 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 246 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 246 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 246 6x29 s9s10 D 166 N.s9s10.08
Polar TM7 F 316 7x55 s5s6 G 80 N.s5s6.09
Hydrophobic C-term V 349 - S6 Y 88 N.S6.06
Polar C-term Y 352 - s17s18 T 323 C.s17s18.39
Van-der-waals C-term Y 352 - s17s18 T 323 C.s17s18.39
Polar C-term S 347 - S6 R 84 N.S6.02
Polar C-term Y 352 - s17s18 D 321 C.s17s18.37
Hydrophobic C-term Y 352 - s17s18 D 321 C.s17s18.37
Van-der-waals C-term Y 352 - s17s18 D 321 C.s17s18.37
Polar TM7 M 317 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 M 317 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 M 317 7x56 s5s6 I 79 N.s5s6.08
Ionic ICL2 D 149 34x53 S16 K 261 C.S16.05
Hydrophobic TM2 F 76 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 76 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 K 142 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 Y 153 34x57 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 Y 153 34x57 s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 F 240 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 F 240 - s17s18 V 324 C.s17s18.40
Polar H8 C 318 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 C 318 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 C 318 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 F 147 34x51 S8 L 136 N.S8.03
Polar ICL2 P 146 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 146 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 146 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic C-term S 347 - S6 R 85 N.S6.03
Van-der-waals C-term S 347 - S6 R 85 N.S6.03
Hydrophobic ICL3 Q 239 - s17s18 T 323 C.s17s18.39
Ionic TM6 R 248 6x31 S6 D 86 N.S6.04
Polar TM6 R 248 6x31 S6 D 86 N.S6.04
Van-der-waals TM6 R 248 6x31 S6 D 86 N.S6.04
Polar TM5 S 236 5x68 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 S 236 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic TM3 V 143 3x54 S6 F 83 N.S6.01
Polar TM6 R 248 6x31 S6 R 84 N.S6.02
Hydrophobic TM6 R 248 6x31 S6 R 84 N.S6.02
Van-der-waals TM6 R 248 6x31 S6 R 84 N.S6.02
Hydrophobic ICL2 P 146 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 146 34x50 s15s16 S 255 C.s15s16.04
Polar TM5 S 236 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 S 236 5x68 S6 R 85 N.S6.03
Ionic ICL1 R 71 - s20c E 394 C.s20c.13
Polar ICL1 R 71 - s20c E 394 C.s20c.13
Hydrophobic ICL1 R 71 - s20c E 394 C.s20c.13
Van-der-waals ICL1 R 71 - s20c E 394 C.s20c.13
Van-der-waals TM3 K 145 3x56 S16 D 257 C.S16.01
Polar TM5 Y 232 5x64 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 Y 232 5x64 s15s16 S 255 C.s15s16.04
Van-der-waals TM5 Y 232 5x64 s15s16 S 255 C.s15s16.04
Polar TM6 H 250 6x33 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 H 250 6x33 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 H 250 6x33 s5s6 T 82 N.s5s6.11
Polar ICL2 P 146 34x50 S16 D 257 C.S16.01
Hydrophobic ICL2 P 146 34x50 S16 D 257 C.S16.01
Van-der-waals ICL2 P 146 34x50 S16 D 257 C.S16.01
Hydrophobic C-term V 349 - S6 L 87 N.S6.05
Polar ICL2 F 147 34x51 S16 Y 259 C.S16.03
Aromatic ICL2 F 147 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 147 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 147 34x51 S16 Y 259 C.S16.03
Polar ICL2 F 147 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 F 147 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 147 34x51 S16 D 257 C.S16.01
Hydrophobic TM5 I 233 5x65 S6 F 83 N.S6.01
Hydrophobic ICL2 F 147 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 147 34x51 S15 V 251 C.S15.14
Hydrophobic C-term R 346 - s9s10 E 165 N.s9s10.07
Van-der-waals C-term R 346 - s9s10 E 165 N.s9s10.07
Hydrophobic TM5 S 236 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 S 236 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM6 H 250 6x33 S6 F 83 N.S6.01
Hydrophobic TM6 H 250 6x33 S6 F 83 N.S6.01
Ionic TM6 R 246 6x29 s9s10 E 165 N.s9s10.07
Polar TM6 R 246 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 246 6x29 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 246 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 F 240 - s17s18 T 323 C.s17s18.39
Van-der-waals ICL3 F 240 - s17s18 T 323 C.s17s18.39
Hydrophobic TM3 V 143 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 V 143 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic H8 S 320 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic C-term R 346 - s9s10 E 164 N.s9s10.06
Hydrophobic C-term Y 352 - s17s18 V 324 C.s17s18.40
Van-der-waals C-term Y 352 - s17s18 V 324 C.s17s18.40
Ionic ICL1 K 73 - s20c E 395 C.s20c.14
Polar ICL1 K 73 - s20c E 395 C.s20c.14
Van-der-waals ICL1 K 73 - s20c E 395 C.s20c.14
Hydrophobic ICL2 F 147 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 147 34x51 S9 C 147 N.S9.01
Ionic TM6 R 246 6x29 s9s10 E 164 N.s9s10.06
Polar TM6 R 246 6x29 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 246 6x29 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 246 6x29 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 F 240 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL3 F 240 - s15s16 L 253 C.s15s16.02
Hydrophobic TM2 T 74 2x37 s5s6 D 75 N.s5s6.04
Aromatic ICL2 Y 153 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Y 153 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 153 34x57 s8s9 K 145 N.s8s9.09
Ionic H8 K 327 8x56 s20c D 402 C.s20c.21
Polar H8 K 327 8x56 s20c D 402 C.s20c.21
Polar ICL3 F 240 - S6 R 85 N.S6.03
Hydrophobic ICL3 F 240 - S6 R 85 N.S6.03
Van-der-waals ICL3 F 240 - S6 R 85 N.S6.03
Polar TM6 H 250 6x33 s15s16 Y 254 C.s15s16.03
Ionic H8 R 323 8x52 s5s6 D 77 N.s5s6.06
Polar H8 R 323 8x52 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 M 317 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 M 317 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 F 76 2x39 s5s6 I 79 N.s5s6.08
Polar C-term R 346 - s9s10 A 163 N.s9s10.05
Hydrophobic C-term R 346 - s9s10 A 163 N.s9s10.05
Van-der-waals C-term R 346 - s9s10 A 163 N.s9s10.05
Hydrophobic C-term V 349 - S6 F 89 N.S6.07
Van-der-waals C-term V 349 - S6 F 89 N.S6.07
Hydrophobic ICL2 P 146 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 146 34x50 S5 Y 71 N.S5.12
Polar TM6 S 253 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 253 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 253 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 F 240 - S6 L 87 N.S6.05
Hydrophobic TM2 T 74 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 T 74 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 F 147 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 147 34x51 s15s16 S 255 C.s15s16.04
Polar TM5 Y 232 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Y 232 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 Y 232 5x64 s15s16 Y 254 C.s15s16.03
Ionic H8 R 319 8x48 s5s6 D 77 N.s5s6.06
Polar H8 R 319 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 319 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 319 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic C-term S 340 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 F 147 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 147 34x51 s8s9 K 145 N.s8s9.09
Polar ICL2 G 148 34x52 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 148 34x52 s8s9 K 145 N.s8s9.09
Polar C-term S 347 - S6 D 86 N.S6.04
Hydrophobic C-term S 347 - S6 D 86 N.S6.04
Van-der-waals C-term S 347 - S6 D 86 N.S6.04
Polar TM3 K 142 3x53 S5 Y 71 N.S5.12
Hydrophobic TM3 K 142 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 K 142 3x53 S5 Y 71 N.S5.12
Polar H8 R 319 8x48 s5s6 V 78 N.s5s6.07
Hydrophobic H8 R 319 8x48 s5s6 V 78 N.s5s6.07
Van-der-waals H8 R 319 8x48 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 233 5x65 s5s6 L 81 N.s5s6.10
Polar TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Aromatic ICL2 F 147 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 147 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 147 34x51 S5 Y 71 N.S5.12
Hydrophobic TM6 H 250 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 H 250 6x33 s5s6 L 81 N.s5s6.10
Polar C-term S 343 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term S 343 - s9s10 D 166 N.s9s10.08
Van-der-waals C-term S 343 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term R 339 - s9s10 K 170 N.s9s10.12
Polar TM6 H 250 6x33 S6 R 84 N.S6.02