Beta-arrestin-2 - GPR88 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR88 73.2
Beta-arrestin-2 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 Q 150 34x54 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 Q 150 34x54 s8s9 P 134 N.s8s9.04
Hydrophobic ICL3 F 231 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 231 - S6 K 78 N.S6.03
Polar TM5 R 225 5x71 s15s16 T 247 C.s15s16.05
Hydrophobic TM5 R 225 5x71 s15s16 T 247 C.s15s16.05
Van-der-waals TM5 R 225 5x71 s15s16 T 247 C.s15s16.05
Hydrophobic ICL3 L 229 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 L 229 - s17s18 V 315 C.s17s18.40
Polar TM5 S 222 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 S 222 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 222 5x68 s15s16 F 245 C.s15s16.03
Polar TM3 L 141 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 141 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 141 3x53 s5s6 R 66 N.s5s6.02
Polar TM5 V 228 5x74 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 V 228 5x74 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 V 228 5x74 s17s18 N 312 C.s17s18.37
Hydrophobic TM3 I 142 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 S 282 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 S 282 - s5s6 L 74 N.s5s6.10
Hydrophobic TM2 S 66 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 226 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 V 226 5x72 s15s16 L 244 C.s15s16.02
Polar ICL1 K 61 12x49 s20c D 406 C.s20c.16
Polar TM5 V 226 5x72 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 V 226 5x72 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 V 226 5x72 s17s18 E 314 C.s17s18.39
Polar TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Polar TM5 V 226 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 V 226 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 V 226 5x72 S6 K 78 N.S6.03
Hydrophobic ICL2 A 147 34x51 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 A 147 34x51 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 F 231 - S6 L 80 N.S6.05
Van-der-waals ICL3 F 231 - S6 L 80 N.S6.05
Hydrophobic TM6 V 286 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 286 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 229 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 L 229 - s17s18 E 314 C.s17s18.39
Polar TM3 L 141 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 L 141 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 L 141 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic ICL3 L 234 - S6 R 77 N.S6.02
Van-der-waals ICL3 L 234 - S6 R 77 N.S6.02
Polar ICL1 K 61 12x49 s20c Q 407 C.s20c.17
Hydrophobic ICL1 K 61 12x49 s20c Q 407 C.s20c.17
Van-der-waals ICL1 K 61 12x49 s20c Q 407 C.s20c.17
Hydrophobic ICL2 P 146 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 146 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 147 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 A 147 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 L 229 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 L 229 - s15s16 L 244 C.s15s16.02
Polar ICL2 A 147 34x51 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 A 147 34x51 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 A 147 34x51 s8s9 D 136 N.s8s9.06
Hydrophobic ICL4 R 339 - s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 142 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 229 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 L 229 - s17s18 N 312 C.s17s18.37
Hydrophobic TM2 S 66 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 66 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic H8 N 340 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 340 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 L 233 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 233 - S6 K 78 N.S6.03
Polar ICL3 Q 278 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 A 145 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 A 145 - s8s9 T 137 N.s8s9.07
Hydrophobic TM5 I 215 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 340 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 R 225 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 225 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 P 146 34x50 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 P 146 34x50 s8s9 G 138 N.s8s9.08
Hydrophobic TM5 V 219 5x65 S6 F 76 N.S6.01
Hydrophobic TM5 V 226 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 226 5x72 s15s16 F 245 C.s15s16.03
Aromatic ICL2 Y 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 149 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 V 219 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 234 - S6 K 78 N.S6.03
Hydrophobic TM3 L 141 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 L 141 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 P 146 34x50 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 146 34x50 s8s9 D 136 N.s8s9.06
Polar TM5 R 218 5x64 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 F 231 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 F 231 - s17s18 V 315 C.s17s18.40
Polar ICL2 P 146 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 146 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 146 34x50 s8s9 T 137 N.s8s9.07