Arrestin-C - GPR88 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR88 73.7
Arrestin-C 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 R 60 12x48 s20c V 380 C.s20c.13
Hydrophobic ICL1 R 60 12x48 s20c V 380 C.s20c.13
Polar TM5 S 222 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 222 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 222 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 142 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 A 145 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 A 145 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 F 231 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 F 231 - s17s18 L 311 C.s17s18.40
Hydrophobic ICL2 P 146 34x50 s8s9 A 133 N.s8s9.07
Ionic TM5 R 225 5x71 S16 D 244 C.S16.01
Polar TM5 R 225 5x71 S16 D 244 C.S16.01
Hydrophobic ICL3 F 231 - S6 L 75 N.S6.05
Van-der-waals ICL3 F 231 - S6 L 75 N.S6.05
Van-der-waals ICL2 Q 150 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 F 231 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 F 231 - s17s18 E 310 C.s17s18.39
Hydrophobic TM3 L 141 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 F 231 - S6 K 73 N.S6.03
Van-der-waals ICL3 F 231 - S6 K 73 N.S6.03
Hydrophobic ICL3 S 282 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 S 282 - s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 142 3x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL3 F 231 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 F 231 - s15s16 L 240 C.s15s16.02
Hydrophobic ICL3 L 229 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 L 229 - s15s16 L 240 C.s15s16.02
Hydrophobic ICL2 A 147 34x51 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 A 147 34x51 s8s9 E 131 N.s8s9.05
Ionic ICL1 R 60 12x48 s20c E 383 C.s20c.17
Polar ICL1 R 60 12x48 s20c E 383 C.s20c.17
Van-der-waals ICL1 R 60 12x48 s20c E 383 C.s20c.17
Polar ICL2 P 146 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 146 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 146 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 L 234 - S6 D 74 N.S6.04
Hydrophobic TM5 V 226 5x72 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 I 215 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 I 215 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 138 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 138 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 141 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 141 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 R 225 5x71 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 225 5x71 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 225 5x71 s15s16 S 242 C.s15s16.04
Polar TM3 L 141 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 L 141 3x53 s8s9 K 135 N.s8s9.09
Polar ICL2 A 147 34x51 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 A 147 34x51 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 A 147 34x51 s8s9 P 130 N.s8s9.04
Hydrophobic ICL3 L 229 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 L 229 - s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 225 5x71 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 R 225 5x71 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 I 142 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 142 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 V 223 5x69 S6 F 71 N.S6.01
Polar ICL3 H 232 - S6 K 73 N.S6.03
Van-der-waals ICL3 H 232 - S6 K 73 N.S6.03
Hydrophobic TM5 V 219 5x65 S6 F 71 N.S6.01
Hydrophobic H8 R 345 8x52 s9s10 K 157 N.s9s10.12
Van-der-waals H8 R 345 8x52 s9s10 K 157 N.s9s10.12
Hydrophobic TM5 V 219 5x65 s5s6 L 69 N.s5s6.10
Polar ICL2 P 146 34x50 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 P 146 34x50 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 P 146 34x50 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 A 145 - s8s9 D 132 N.s8s9.06
Hydrophobic TM2 S 66 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 S 66 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 L 229 - s15s16 V 239 C.s15s16.01
Van-der-waals ICL3 L 229 - s15s16 V 239 C.s15s16.01
Hydrophobic ICL2 P 146 34x50 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 P 146 34x50 s8s9 G 134 N.s8s9.08
Polar TM3 R 138 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 138 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 V 226 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 226 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 146 34x50 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 P 146 34x50 s8s9 P 130 N.s8s9.04