ArrestinDb

Arrestin-C - GPR88 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR88	73.7
Arrestin-C	81.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 21.3

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	ICL1	R	60	12x48	s20c	V	380	C.s20c.13
Hydrophobic	TM5	S	222	5x68	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM3	I	142	3x54	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	A	145	-	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL3	F	231	-	s17s18	L	311	C.s17s18.40
Hydrophobic	ICL2	P	146	34x50	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL3	F	231	-	S6	L	75	N.S6.05
Hydrophobic	ICL3	F	231	-	s17s18	E	310	C.s17s18.39
Hydrophobic	TM3	L	141	3x53	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL3	F	231	-	S6	K	73	N.S6.03
Hydrophobic	ICL3	S	282	-	s5s6	L	69	N.s5s6.10
Hydrophobic	TM3	I	142	3x54	s8s9	K	135	N.s8s9.09
Hydrophobic	ICL3	F	231	-	s15s16	L	240	C.s15s16.02
Hydrophobic	ICL3	L	229	-	s15s16	L	240	C.s15s16.02
Hydrophobic	ICL2	A	147	34x51	s8s9	E	131	N.s8s9.05
Hydrophobic	ICL2	P	146	34x50	s5s6	R	61	N.s5s6.02
Hydrophobic	ICL3	L	234	-	S6	D	74	N.S6.04
Hydrophobic	TM5	V	226	5x72	s15s16	L	240	C.s15s16.02
Hydrophobic	TM5	I	215	5x61	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	R	138	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	L	141	3x53	s5s6	D	63	N.s5s6.04
Hydrophobic	TM5	R	225	5x71	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM5	R	225	5x71	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	A	147	34x51	s8s9	P	130	N.s8s9.04
Hydrophobic	ICL3	L	229	-	s17s18	E	310	C.s17s18.39
Hydrophobic	TM5	R	225	5x71	s15s16	L	243	C.s15s16.05
Hydrophobic	TM3	I	142	3x54	s5s6	I	67	N.s5s6.08
Hydrophobic	TM5	V	223	5x69	S6	F	71	N.S6.01
Hydrophobic	TM5	V	219	5x65	S6	F	71	N.S6.01
Hydrophobic	H8	R	345	8x52	s9s10	K	157	N.s9s10.12
Hydrophobic	TM5	V	219	5x65	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	P	146	34x50	s8s9	D	132	N.s8s9.06
Hydrophobic	ICL2	A	145	-	s8s9	D	132	N.s8s9.06
Hydrophobic	TM2	S	66	2x39	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL3	L	229	-	s15s16	V	239	C.s15s16.01
Hydrophobic	ICL2	P	146	34x50	s8s9	G	134	N.s8s9.08
Hydrophobic	TM3	R	138	3x50	s5s6	V	66	N.s5s6.07
Hydrophobic	TM5	V	226	5x72	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	P	146	34x50	s8s9	P	130	N.s8s9.04
Ionic	TM5	R	225	5x71	S16	D	244	C.S16.01
Ionic	ICL1	R	60	12x48	s20c	E	383	C.s20c.17
Polar	ICL1	R	60	12x48	s20c	V	380	C.s20c.13
Polar	TM5	S	222	5x68	s15s16	Y	241	C.s15s16.03
Polar	TM5	R	225	5x71	S16	D	244	C.S16.01
Polar	ICL1	R	60	12x48	s20c	E	383	C.s20c.17
Polar	ICL2	P	146	34x50	s5s6	R	61	N.s5s6.02
Polar	TM3	L	141	3x53	s8s9	K	135	N.s8s9.09
Polar	ICL2	A	147	34x51	s8s9	P	130	N.s8s9.04
Polar	ICL3	H	232	-	S6	K	73	N.S6.03
Polar	ICL2	P	146	34x50	s8s9	D	132	N.s8s9.06
Polar	TM3	R	138	3x50	s5s6	V	66	N.s5s6.07
Van-der-waals	TM5	S	222	5x68	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	A	145	-	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL3	F	231	-	s17s18	L	311	C.s17s18.40
Van-der-waals	ICL3	F	231	-	S6	L	75	N.S6.05
Van-der-waals	ICL2	Q	150	34x54	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL3	F	231	-	s17s18	E	310	C.s17s18.39
Van-der-waals	ICL3	F	231	-	S6	K	73	N.S6.03
Van-der-waals	ICL3	S	282	-	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL3	F	231	-	s15s16	L	240	C.s15s16.02
Van-der-waals	ICL3	L	229	-	s15s16	L	240	C.s15s16.02
Van-der-waals	ICL2	A	147	34x51	s8s9	E	131	N.s8s9.05
Van-der-waals	ICL1	R	60	12x48	s20c	E	383	C.s20c.17
Van-der-waals	ICL2	P	146	34x50	s5s6	R	61	N.s5s6.02
Van-der-waals	TM5	I	215	5x61	s5s6	I	67	N.s5s6.08
Van-der-waals	TM3	R	138	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	TM3	L	141	3x53	s5s6	D	63	N.s5s6.04
Van-der-waals	TM5	R	225	5x71	s15s16	Y	241	C.s15s16.03
Van-der-waals	TM3	L	141	3x53	s8s9	K	135	N.s8s9.09
Van-der-waals	ICL2	A	147	34x51	s8s9	P	130	N.s8s9.04
Van-der-waals	ICL3	L	229	-	s17s18	E	310	C.s17s18.39
Van-der-waals	TM5	R	225	5x71	s15s16	L	243	C.s15s16.05
Van-der-waals	TM3	I	142	3x54	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL3	H	232	-	S6	K	73	N.S6.03
Van-der-waals	H8	R	345	8x52	s9s10	K	157	N.s9s10.12
Van-der-waals	ICL2	P	146	34x50	s8s9	D	132	N.s8s9.06
Van-der-waals	TM2	S	66	2x39	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL3	L	229	-	s15s16	V	239	C.s15s16.01
Van-der-waals	ICL2	P	146	34x50	s8s9	G	134	N.s8s9.08
Van-der-waals	TM5	V	226	5x72	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	P	146	34x50	s8s9	P	130	N.s8s9.04

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Main reference

Arrestin-C - GPR88 complex model Download Full