ArrestinDb

Beta-arrestin-1 - mGlu₃ receptor complex model

Full

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
mGlu₃	75.0
Beta-arrestin-1	78.8

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 23.3

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	C-term	F	844	-	S6	K	77	N.S6.03
Hydrophobic	H8	R	838	8x54	s5s6	T	74	N.s5s6.11
Hydrophobic	C-term	F	844	-	S6	K	77	N.S6.03
Hydrophobic	C-term	T	864	-	S16	Q	248	C.S16.02
Hydrophobic	C-term	C	866	-	S16	C	251	C.S16.05
Hydrophobic	TM3	F	670	3x58	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	R	679	-	s15s16	N	245	C.s15s16.04
Hydrophobic	ICL1	K	608	12x51	s5s6	V	70	N.s5s6.07
Hydrophobic	H8	H	837	8x53	s20c	E	407	C.s20c.17
Hydrophobic	C-term	C	866	-	S16	K	250	C.S16.04
Hydrophobic	ICL3	F	765	-	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	A	677	-	s15s16	F	244	C.s15s16.03
Hydrophobic	C-term	V	846	-	S6	K	77	N.S6.03
Hydrophobic	C-term	N	867	-	s17s18	K	284	C.s17s18.10
Hydrophobic	H8	L	841	8x57	S6	F	75	N.S6.01
Hydrophobic	C-term	T	875	-	S19	D	342	C.S19.02
Hydrophobic	ICL1	A	609	12x52	s5s6	V	70	N.s5s6.07
Hydrophobic	H8	L	839	8x55	s5s6	G	72	N.s5s6.09
Hydrophobic	C-term	C	866	-	s17s18	L	287	C.s17s18.13
Hydrophobic	C-term	Y	861	-	S16	Q	248	C.S16.02
Hydrophobic	TM3	I	669	3x57	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL2	Q	678	-	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	I	683	-	s5s6	R	65	N.s5s6.02
Hydrophobic	ICL1	K	608	12x51	s5s6	E	66	N.s5s6.03
Hydrophobic	ICL3	F	765	-	s5s6	L	71	N.s5s6.08
Hydrophobic	C-term	Y	853	-	s17s18	N	311	C.s17s18.37
Hydrophobic	ICL1	A	609	12x52	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL3	F	765	-	s5s6	G	72	N.s5s6.09
Hydrophobic	C-term	R	843	-	S6	D	78	N.S6.04
Hydrophobic	C-term	Y	861	-	S15	D	240	C.S15.13
Hydrophobic	H8	H	837	8x53	s9s10	K	160	N.s9s10.12
Hydrophobic	H8	R	838	8x54	S5	R	62	N.S5.11
Hydrophobic	C-term	C	866	-	s17s18	R	285	C.s17s18.11
Hydrophobic	ICL1	P	605	12x48	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	T	864	-	s8s9	D	135	N.s8s9.06
Hydrophobic	C-term	L	879	-	s11s12	L	191	C.s11s12.02
Hydrophobic	H8	L	841	8x57	s5s6	T	74	N.s5s6.11
Hydrophobic	ICL2	A	677	-	s15s16	L	243	C.s15s16.02
Hydrophobic	H8	V	835	8x51	s5s6	D	69	N.s5s6.06
Hydrophobic	TM3	I	669	3x57	s5s6	L	68	N.s5s6.05
Hydrophobic	C-term	T	864	-	S16	Y	249	C.S16.03
Hydrophobic	C-term	N	867	-	s17s18	R	285	C.s17s18.11
Hydrophobic	ICL2	P	680	-	s15s16	F	244	C.s15s16.03
Hydrophobic	H8	L	841	8x57	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	R	843	-	S6	V	81	N.S6.07
Hydrophobic	H8	L	839	8x55	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	R	679	-	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	V	673	-	S6	F	75	N.S6.01
Hydrophobic	ICL3	P	762	-	s5s6	L	73	N.s5s6.10
Hydrophobic	TM3	I	669	3x57	s5s6	L	73	N.s5s6.10
Hydrophobic	H8	H	840	8x56	S6	R	76	N.S6.02
Hydrophobic	ICL2	R	679	-	s5s6	R	65	N.s5s6.02
Hydrophobic	C-term	S	859	-	s15s16	T	246	C.s15s16.05
Hydrophobic	C-term	Y	853	-	s17s18	E	313	C.s17s18.39
Hydrophobic	C-term	C	866	-	s17s18	G	286	C.s17s18.12
Ionic	C-term	D	873	-	S18	K	326	C.S18.10
Ionic	H8	H	837	8x53	s20c	E	407	C.s20c.17
Ionic	ICL1	K	608	12x51	s5s6	E	66	N.s5s6.03
Ionic	C-term	R	843	-	S6	D	78	N.S6.04
Ionic	C-term	D	873	-	S15	R	236	C.S15.09
Ionic	C-term	D	873	-	S18	K	324	C.S18.08
Polar	C-term	T	864	-	S16	Q	248	C.S16.02
Polar	C-term	C	866	-	S16	C	251	C.S16.05
Polar	C-term	D	873	-	S18	K	326	C.S18.10
Polar	ICL2	R	679	-	s15s16	N	245	C.s15s16.04
Polar	H8	H	837	8x53	s20c	E	407	C.s20c.17
Polar	C-term	C	866	-	S16	K	250	C.S16.04
Polar	C-term	V	862	-	S16	Q	248	C.S16.02
Polar	ICL2	A	677	-	s15s16	F	244	C.s15s16.03
Polar	H8	H	837	8x53	s20c	E	405	C.s20c.15
Polar	C-term	T	875	-	S19	D	342	C.S19.02
Polar	H8	H	840	8x56	S10	R	165	N.S10.03
Polar	C-term	V	862	-	s15s16	T	246	C.s15s16.05
Polar	H8	L	839	8x55	s5s6	G	72	N.s5s6.09
Polar	C-term	C	866	-	s17s18	L	287	C.s17s18.13
Polar	C-term	R	843	-	S6	N	83	N.S6.09
Polar	ICL1	K	608	12x51	s5s6	E	66	N.s5s6.03
Polar	C-term	Y	853	-	s17s18	N	311	C.s17s18.37
Polar	C-term	F	844	-	S6	D	78	N.S6.04
Polar	H8	L	839	8x55	s5s6	T	74	N.s5s6.11
Polar	C-term	R	843	-	S6	D	78	N.S6.04
Polar	C-term	T	864	-	S16	K	250	C.S16.04
Polar	C-term	Y	861	-	S15	D	240	C.S15.13
Polar	H8	H	837	8x53	s9s10	K	160	N.s9s10.12
Polar	C-term	C	866	-	s17s18	R	285	C.s17s18.11
Polar	C-term	D	873	-	S15	R	236	C.S15.09
Polar	C-term	T	860	-	s15s16	T	246	C.s15s16.05
Polar	C-term	T	864	-	S16	Y	249	C.S16.03
Polar	C-term	N	867	-	s17s18	R	285	C.s17s18.11
Polar	C-term	D	873	-	S18	K	324	C.S18.08
Polar	ICL2	R	679	-	s15s16	F	244	C.s15s16.03
Polar	C-term	R	843	-	S5	T	58	N.S5.07
Polar	H8	H	840	8x56	S6	R	76	N.S6.02
Polar	C-term	C	866	-	s17s18	G	286	C.s17s18.12
Van-der-waals	H8	R	838	8x54	s5s6	T	74	N.s5s6.11
Van-der-waals	C-term	T	864	-	S16	Q	248	C.S16.02
Van-der-waals	C-term	C	866	-	S16	C	251	C.S16.05
Van-der-waals	C-term	D	873	-	S18	K	326	C.S18.10
Van-der-waals	TM3	F	670	3x58	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	R	679	-	s15s16	N	245	C.s15s16.04
Van-der-waals	ICL1	K	608	12x51	s5s6	V	70	N.s5s6.07
Van-der-waals	H8	H	837	8x53	s20c	E	407	C.s20c.17
Van-der-waals	C-term	C	866	-	S16	K	250	C.S16.04
Van-der-waals	C-term	V	862	-	S16	Q	248	C.S16.02
Van-der-waals	ICL3	F	765	-	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	A	677	-	s15s16	F	244	C.s15s16.03
Van-der-waals	C-term	N	867	-	s17s18	K	284	C.s17s18.10
Van-der-waals	C-term	P	863	-	S16	Q	248	C.S16.02
Van-der-waals	C-term	T	875	-	S19	D	342	C.S19.02
Van-der-waals	H8	H	840	8x56	S10	R	165	N.S10.03
Van-der-waals	ICL1	A	609	12x52	s5s6	V	70	N.s5s6.07
Van-der-waals	H8	L	839	8x55	s5s6	G	72	N.s5s6.09
Van-der-waals	C-term	G	868	-	s8s9	E	134	N.s8s9.05
Van-der-waals	H8	V	834	8x50	s20c	E	405	C.s20c.15
Van-der-waals	C-term	Y	861	-	S16	Q	248	C.S16.02
Van-der-waals	ICL1	K	608	12x51	s5s6	E	66	N.s5s6.03
Van-der-waals	ICL3	F	765	-	s5s6	L	71	N.s5s6.08
Van-der-waals	C-term	Y	853	-	s17s18	N	311	C.s17s18.37
Van-der-waals	C-term	F	844	-	S6	D	78	N.S6.04
Van-der-waals	H8	L	839	8x55	s5s6	T	74	N.s5s6.11
Van-der-waals	ICL1	A	609	12x52	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL3	F	765	-	s5s6	G	72	N.s5s6.09
Van-der-waals	C-term	R	843	-	S6	D	78	N.S6.04
Van-der-waals	C-term	Y	861	-	S15	D	240	C.S15.13
Van-der-waals	H8	H	837	8x53	s9s10	K	160	N.s9s10.12
Van-der-waals	H8	R	838	8x54	S5	R	62	N.S5.11
Van-der-waals	C-term	C	866	-	s17s18	R	285	C.s17s18.11
Van-der-waals	ICL1	P	605	12x48	s5s6	V	70	N.s5s6.07
Van-der-waals	C-term	D	873	-	S15	R	236	C.S15.09
Van-der-waals	H8	L	841	8x57	s5s6	T	74	N.s5s6.11
Van-der-waals	TM3	I	669	3x57	s5s6	L	68	N.s5s6.05
Van-der-waals	C-term	T	864	-	S16	Y	249	C.S16.03
Van-der-waals	C-term	N	867	-	s17s18	R	285	C.s17s18.11
Van-der-waals	ICL2	P	680	-	s15s16	F	244	C.s15s16.03
Van-der-waals	H8	L	841	8x57	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	R	843	-	S6	V	81	N.S6.07
Van-der-waals	C-term	D	873	-	S18	K	324	C.S18.08
Van-der-waals	ICL2	R	679	-	s15s16	F	244	C.s15s16.03
Van-der-waals	C-term	R	843	-	S5	T	58	N.S5.07
Van-der-waals	TM3	I	669	3x57	s5s6	L	73	N.s5s6.10
Van-der-waals	H8	H	840	8x56	S6	R	76	N.S6.02
Van-der-waals	ICL2	R	679	-	s5s6	R	65	N.s5s6.02
Van-der-waals	C-term	S	859	-	s15s16	T	246	C.s15s16.05
Van-der-waals	C-term	C	866	-	s17s18	G	286	C.s17s18.12

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Main reference

Beta-arrestin-1 - mGlu3 receptor complex model Download Full