Arrestin-C - mGlu3 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
mGlu3 72.9
Arrestin-C 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 765 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 F 765 - s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 680 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 680 - s15s16 Y 241 C.s15s16.03
Hydrophobic H8 N 833 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 Q 678 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 Q 678 - s15s16 L 243 C.s15s16.05
Polar ICL1 A 609 12x52 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 A 609 12x52 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 A 609 12x52 s5s6 D 63 N.s5s6.04
Polar H8 T 836 8x52 s5s6 G 68 N.s5s6.09
Hydrophobic H8 T 836 8x52 s5s6 G 68 N.s5s6.09
Van-der-waals H8 T 836 8x52 s5s6 G 68 N.s5s6.09
Aromatic H8 H 837 8x53 S5 R 58 N.S5.11
Hydrophobic H8 H 837 8x53 S5 R 58 N.S5.11
Hydrophobic H8 R 838 8x54 S6 R 72 N.S6.02
Polar ICL2 A 677 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL3 F 765 - s5s6 I 67 N.s5s6.08
Van-der-waals ICL3 F 765 - s5s6 I 67 N.s5s6.08
Polar ICL2 R 679 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 R 679 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 R 679 - s15s16 S 242 C.s15s16.04
Hydrophobic H8 R 838 8x54 S9 K 144 N.S9.08
Polar ICL2 R 679 - s8s9 A 133 N.s8s9.07
Ionic H8 R 838 8x54 S9 E 142 N.S9.06
Polar H8 R 838 8x54 S9 E 142 N.S9.06
Van-der-waals H8 R 838 8x54 S9 E 142 N.S9.06
Hydrophobic H8 H 837 8x53 S6 R 72 N.S6.02
Van-der-waals H8 H 837 8x53 S6 R 72 N.S6.02
Hydrophobic H8 L 841 8x57 S6 K 73 N.S6.03
Van-der-waals H8 L 841 8x57 S6 K 73 N.S6.03
Polar ICL2 A 677 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 A 677 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 677 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL1 A 609 12x52 s5s6 I 67 N.s5s6.08
Van-der-waals ICL1 A 609 12x52 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 A 677 - s15s16 V 239 C.s15s16.01
Van-der-waals ICL2 A 677 - s15s16 V 239 C.s15s16.01
Hydrophobic H8 V 835 8x51 s5s6 V 66 N.s5s6.07
Hydrophobic H8 R 838 8x54 S10 Y 160 N.S10.01
Polar C-term R 843 - S6 T 79 N.S6.09
Van-der-waals C-term R 843 - S6 T 79 N.S6.09
Hydrophobic H8 L 839 8x55 S6 F 71 N.S6.01
Polar ICL2 R 679 - S5 Y 59 N.S5.12
Van-der-waals ICL2 R 679 - S5 Y 59 N.S5.12
Hydrophobic TM6 E 767 6x35 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 F 670 3x58 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 F 670 3x58 s5s6 L 69 N.s5s6.10
Hydrophobic H8 L 839 8x55 s5s6 T 70 N.s5s6.11
Van-der-waals H8 L 839 8x55 s5s6 T 70 N.s5s6.11
Polar H8 T 836 8x52 s5s6 T 70 N.s5s6.11
Van-der-waals H8 T 836 8x52 s5s6 T 70 N.s5s6.11
Polar H8 T 836 8x52 s5s6 E 65 N.s5s6.06
Van-der-waals H8 T 836 8x52 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 Q 678 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 Q 678 - s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 679 - S16 D 244 C.S16.01
Polar ICL2 R 679 - S16 D 244 C.S16.01
Hydrophobic ICL2 R 679 - S16 D 244 C.S16.01
Van-der-waals ICL2 R 679 - S16 D 244 C.S16.01
Polar H8 H 837 8x53 s5s6 T 70 N.s5s6.11
Hydrophobic H8 H 837 8x53 s5s6 T 70 N.s5s6.11
Van-der-waals H8 H 837 8x53 s5s6 T 70 N.s5s6.11
Hydrophobic H8 L 841 8x57 S6 R 72 N.S6.02
Hydrophobic H8 L 839 8x55 S6 R 72 N.S6.02
Van-der-waals H8 L 839 8x55 S6 R 72 N.S6.02
Van-der-waals ICL3 N 764 - s5s6 I 67 N.s5s6.08
Polar ICL2 R 679 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 R 679 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 679 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 A 677 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 A 677 - s15s16 L 240 C.s15s16.02
Hydrophobic ICL1 P 605 12x48 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 P 605 12x48 s5s6 V 66 N.s5s6.07
Hydrophobic H8 V 835 8x51 s5s6 D 62 N.s5s6.03
Hydrophobic ICL3 F 765 - s5s6 G 68 N.s5s6.09
Van-der-waals ICL3 F 765 - s5s6 G 68 N.s5s6.09
Hydrophobic TM3 I 669 3x57 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 669 3x57 s5s6 L 69 N.s5s6.10
Hydrophobic ICL1 A 609 12x52 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 669 3x57 S6 F 71 N.S6.01
Van-der-waals TM3 I 669 3x57 S6 F 71 N.S6.01
Hydrophobic ICL1 K 608 12x51 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 K 608 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic H8 V 834 8x50 s5s6 V 66 N.s5s6.07
Van-der-waals H8 V 834 8x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 L 606 12x49 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 L 606 12x49 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 A 677 - s15s16 L 243 C.s15s16.05
Polar C-term R 843 - S6 V 77 N.S6.07
Hydrophobic C-term R 843 - S6 V 77 N.S6.07
Van-der-waals C-term R 843 - S6 V 77 N.S6.07
Hydrophobic H8 V 835 8x51 s5s6 E 65 N.s5s6.06
Van-der-waals H8 V 835 8x51 s5s6 E 65 N.s5s6.06
Polar H8 R 838 8x54 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 V 673 - S6 F 71 N.S6.01
Van-der-waals ICL2 V 673 - S6 F 71 N.S6.01
Ionic H8 H 837 8x53 s5s6 E 65 N.s5s6.06
Polar H8 H 837 8x53 s5s6 E 65 N.s5s6.06
Hydrophobic H8 H 837 8x53 s5s6 E 65 N.s5s6.06
Van-der-waals H8 H 837 8x53 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 A 677 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 A 677 - s17s18 E 310 C.s17s18.39