S-arrestin - mGlu4 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
mGlu4 71.3
S-arrestin 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 K 857 8x54 S6 R 84 N.S6.02
Van-der-waals H8 K 857 8x54 S6 R 84 N.S6.02
Ionic H8 R 856 8x53 s9s10 D 166 N.s9s10.08
Polar H8 R 856 8x53 s9s10 D 166 N.s9s10.08
Hydrophobic H8 R 856 8x53 s9s10 D 166 N.s9s10.08
Van-der-waals H8 R 856 8x53 s9s10 D 166 N.s9s10.08
Hydrophobic H8 L 860 8x57 S6 Y 88 N.S6.06
Polar ICL2 V 688 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 688 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 688 - s8s9 K 145 N.s8s9.09
Polar TM3 G 684 3x61 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 G 684 3x61 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 G 684 3x61 s15s16 S 255 C.s15s16.04
Hydrophobic ICL3 F 781 - s5s6 L 81 N.s5s6.10
Van-der-waals ICL3 F 781 - s5s6 L 81 N.s5s6.10
Hydrophobic TM3 K 685 3x62 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 V 688 - S8 L 136 N.S8.03
Van-der-waals ICL2 V 688 - S8 L 136 N.S8.03
Polar TM3 G 684 3x61 S5 Y 71 N.S5.12
Van-der-waals TM3 G 684 3x61 S5 Y 71 N.S5.12
Polar ICL2 A 690 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 A 690 - s8s9 D 142 N.s8s9.06
Polar H8 K 857 8x54 S6 R 85 N.S6.03
Hydrophobic H8 K 857 8x54 S6 R 85 N.S6.03
Van-der-waals H8 K 857 8x54 S6 R 85 N.S6.03
Hydrophobic H8 L 860 8x57 S6 L 87 N.S6.05
Van-der-waals H8 L 860 8x57 S6 L 87 N.S6.05
Hydrophobic ICL2 A 690 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 A 690 - s8s9 G 144 N.s8s9.08
Polar TM3 S 687 3x64 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 S 687 3x64 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 S 687 3x64 s8s9 K 145 N.s8s9.09
Polar TM3 K 685 3x62 S16 D 257 C.S16.01
Hydrophobic TM3 K 685 3x62 S16 D 257 C.S16.01
Van-der-waals TM3 K 685 3x62 S16 D 257 C.S16.01
Hydrophobic H8 S 859 8x56 S6 F 89 N.S6.07
Van-der-waals H8 S 859 8x56 S6 F 89 N.S6.07
Polar ICL2 S 689 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 689 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 689 - s8s9 K 145 N.s8s9.09
Ionic H8 R 856 8x53 s9s10 E 165 N.s9s10.07
Polar H8 R 856 8x53 s9s10 E 165 N.s9s10.07
Hydrophobic H8 R 856 8x53 s9s10 E 165 N.s9s10.07
Van-der-waals H8 R 856 8x53 s9s10 E 165 N.s9s10.07
Hydrophobic ICL1 A 620 12x52 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 V 688 - s17s18 G 296 C.s17s18.12
Polar ICL2 V 688 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 688 - S16 Y 259 C.S16.03
Van-der-waals ICL2 V 688 - S16 Y 259 C.S16.03
Polar H8 L 860 8x57 S6 D 86 N.S6.04
Hydrophobic H8 L 860 8x57 S6 D 86 N.S6.04
Van-der-waals H8 L 860 8x57 S6 D 86 N.S6.04
Polar ICL2 S 689 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 S 689 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 S 689 - s8s9 D 142 N.s8s9.06
Polar ICL2 R 692 - s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 R 676 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 676 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 K 619 12x51 s5s6 I 79 N.s5s6.08
Van-der-waals ICL1 K 619 12x51 s5s6 I 79 N.s5s6.08
Polar TM3 S 687 3x64 S16 Y 259 C.S16.03
Hydrophobic TM3 S 687 3x64 S16 Y 259 C.S16.03
Van-der-waals TM3 S 687 3x64 S16 Y 259 C.S16.03
Polar TM3 Q 683 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 Q 683 3x60 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 Q 683 3x60 s8s9 K 145 N.s8s9.09
Polar H8 K 857 8x54 S5 F 69 N.S5.10
Hydrophobic C-term V 864 - s7s8 Y 129 N.s7s8.05
Van-der-waals C-term V 864 - s7s8 Y 129 N.s7s8.05
Polar TM3 S 687 3x64 S16 D 257 C.S16.01
Van-der-waals TM3 S 687 3x64 S16 D 257 C.S16.01
Hydrophobic H8 S 859 8x56 S6 D 86 N.S6.04
Hydrophobic ICL2 P 691 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 688 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 V 688 - s8s9 D 142 N.s8s9.06
Aromatic ICL3 F 781 - S6 F 83 N.S6.01
Hydrophobic ICL3 F 781 - S6 F 83 N.S6.01
Van-der-waals ICL3 F 781 - S6 F 83 N.S6.01
Hydrophobic H8 R 858 8x55 S6 D 86 N.S6.04
Polar ICL1 A 620 12x52 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 A 620 12x52 s5s6 I 79 N.s5s6.08
Van-der-waals ICL1 A 620 12x52 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 680 3x57 S6 F 83 N.S6.01
Polar TM3 R 686 3x63 S16 D 257 C.S16.01
Hydrophobic TM3 R 686 3x63 S16 D 257 C.S16.01
Van-der-waals TM3 R 686 3x63 S16 D 257 C.S16.01
Hydrophobic ICL2 A 690 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 690 - s8s9 K 145 N.s8s9.09
Van-der-waals TM3 F 681 3x58 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 G 684 3x61 S16 D 257 C.S16.01
Van-der-waals TM3 G 684 3x61 S16 D 257 C.S16.01
Hydrophobic H8 K 857 8x54 S5 A 68 N.S5.09
Van-der-waals H8 K 857 8x54 S5 A 68 N.S5.09
Hydrophobic ICL2 V 688 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 V 688 - s8s9 P 138 N.s8s9.02
Hydrophobic TM3 G 684 3x61 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 G 684 3x61 s8s9 K 145 N.s8s9.09
Ionic H8 K 857 8x54 S6 D 86 N.S6.04
Polar H8 K 857 8x54 S6 D 86 N.S6.04
Hydrophobic H8 K 857 8x54 S6 D 86 N.S6.04
Van-der-waals H8 K 857 8x54 S6 D 86 N.S6.04