Beta-arrestin-2 - mGlu6 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
mGlu6 77.5
Beta-arrestin-2 76.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 617 12x51 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 R 617 12x51 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 F 779 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 F 779 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 R 674 3x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 674 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 A 618 12x52 s5s6 L 72 N.s5s6.08
Van-der-waals ICL1 A 618 12x52 s5s6 L 72 N.s5s6.08
Hydrophobic H8 V 851 8x50 s9s10 K 158 N.s9s10.09
Van-der-waals H8 V 851 8x50 s9s10 K 158 N.s9s10.09
Hydrophobic H8 K 855 8x54 S6 K 78 N.S6.03
Hydrophobic TM6 F 779 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 F 779 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 678 3x57 s5s6 L 74 N.s5s6.10
Van-der-waals H8 K 855 8x54 S6 D 79 N.S6.04
Hydrophobic ICL2 V 686 - S15 I 242 C.S15.14
Polar TM3 R 674 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 678 3x57 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 678 3x57 s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 K 683 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL3 P 776 - s15s16 F 245 C.s15s16.03
Polar ICL2 G 682 - S5 Y 64 N.S5.12
Hydrophobic H8 L 858 8x57 S6 L 80 N.S6.05
Hydrophobic H8 R 854 8x53 S6 R 77 N.S6.02
Hydrophobic ICL2 V 686 - S8 L 130 N.S8.03
Hydrophobic H8 R 856 8x55 S6 D 79 N.S6.04
Polar ICL1 A 618 12x52 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 A 618 12x52 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 A 618 12x52 s5s6 V 71 N.s5s6.07
Polar ICL2 V 686 - S16 Y 250 C.S16.03
Hydrophobic ICL2 V 686 - S16 Y 250 C.S16.03
Van-der-waals ICL2 V 686 - S16 Y 250 C.S16.03
Polar H8 S 857 8x56 S6 D 79 N.S6.04
Hydrophobic H8 S 857 8x56 S6 D 79 N.S6.04
Van-der-waals H8 S 857 8x56 S6 D 79 N.S6.04
Hydrophobic ICL2 K 683 - S16 A 248 C.S16.01
Aromatic TM3 F 679 3x58 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 F 679 3x58 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 F 679 3x58 s15s16 F 245 C.s15s16.03
Polar H8 L 858 8x57 S6 D 79 N.S6.04
Van-der-waals H8 L 858 8x57 S6 D 79 N.S6.04
Hydrophobic TM3 F 679 3x58 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 F 679 3x58 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 688 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 688 - s5s6 R 66 N.s5s6.02
Polar H8 Q 852 8x51 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 855 8x54 S6 F 76 N.S6.01
Van-der-waals H8 K 855 8x54 S6 F 76 N.S6.01
Ionic H8 R 854 8x53 S9 E 146 N.S9.06
Polar H8 R 854 8x53 S9 E 146 N.S9.06
Polar ICL2 K 683 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 K 683 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 K 683 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 686 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 686 - S5 Y 64 N.S5.12
Hydrophobic ICL1 A 618 12x52 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 I 678 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 678 3x57 s5s6 L 69 N.s5s6.05
Polar ICL2 G 682 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 G 682 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 G 682 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 686 - S16 A 248 C.S16.01
Polar H8 S 857 8x56 S6 I 82 N.S6.07
Hydrophobic H8 S 857 8x56 S6 I 82 N.S6.07
Van-der-waals H8 S 857 8x56 S6 I 82 N.S6.07
Polar H8 K 855 8x54 S6 R 77 N.S6.02
Hydrophobic H8 K 855 8x54 S6 R 77 N.S6.02
Van-der-waals H8 K 855 8x54 S6 R 77 N.S6.02