Arrestin-C - mGlu7 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
mGlu7 72.7
Arrestin-C 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 G 687 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 G 687 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 G 687 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 683 3x57 S6 F 71 N.S6.01
Van-der-waals TM3 I 683 3x57 S6 F 71 N.S6.01
Hydrophobic ICL2 K 689 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 K 689 - s17s18 E 310 C.s17s18.39
Polar ICL2 A 693 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 A 693 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 A 693 - s15s16 S 242 C.s15s16.04
Polar ICL2 V 691 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 V 691 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 691 - s15s16 S 242 C.s15s16.04
Hydrophobic H8 K 858 8x52 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 858 8x52 s5s6 D 62 N.s5s6.03
Aromatic TM3 F 684 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 F 684 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 F 684 3x58 S6 F 71 N.S6.01
Hydrophobic TM6 F 784 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 F 684 3x58 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 F 684 3x58 s5s6 L 69 N.s5s6.10
Polar H8 K 860 8x54 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 860 8x54 s5s6 D 62 N.s5s6.03
Polar ICL3 N 783 - s5s6 G 68 N.s5s6.09
Hydrophobic ICL3 N 783 - s5s6 G 68 N.s5s6.09
Van-der-waals ICL3 N 783 - s5s6 G 68 N.s5s6.09
Polar ICL3 N 783 - s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 N 783 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 N 783 - s5s6 L 69 N.s5s6.10
Aromatic TM6 F 784 6x33 S6 F 71 N.S6.01
Hydrophobic TM6 F 784 6x33 S6 F 71 N.S6.01
Van-der-waals TM6 F 784 6x33 S6 F 71 N.S6.01
Hydrophobic ICL3 N 783 - s5s6 I 67 N.s5s6.08
Van-der-waals ICL3 N 783 - s5s6 I 67 N.s5s6.08
Hydrophobic TM6 F 784 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 F 784 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 F 784 6x33 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 V 691 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 691 - s15s16 Y 241 C.s15s16.03
Polar TM6 N 785 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 N 785 6x34 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 N 785 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 T 692 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 T 692 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 T 692 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 T 692 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL3 V 780 - s5s6 L 69 N.s5s6.10
Polar C-term Y 910 - h1s7 D 107 N.h1s7.02
Hydrophobic C-term Y 910 - h1s7 D 107 N.h1s7.02
Van-der-waals C-term Y 910 - h1s7 D 107 N.h1s7.02
Hydrophobic ICL2 V 691 - S15 V 238 C.S15.14
Van-der-waals ICL2 V 691 - S15 V 238 C.S15.14
Polar H8 K 860 8x54 s8s9 Q 127 N.s8s9.01
Ionic H8 R 861 8x55 s20c E 383 C.s20c.17
Polar H8 R 861 8x55 s20c E 383 C.s20c.17
Hydrophobic H8 R 861 8x55 s20c E 383 C.s20c.17
Van-der-waals H8 R 861 8x55 s20c E 383 C.s20c.17
Hydrophobic ICL1 A 623 12x52 s5s6 I 67 N.s5s6.08
Van-der-waals ICL1 A 623 12x52 s5s6 I 67 N.s5s6.08
Hydrophobic ICL1 P 619 12x48 s5s6 V 66 N.s5s6.07
Polar ICL3 N 783 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 N 783 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 V 691 - s17s18 E 310 C.s17s18.39
Hydrophobic TM6 E 786 6x35 s5s6 I 67 N.s5s6.08
Polar ICL2 S 690 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 S 690 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 V 691 - s15s16 V 239 C.s15s16.01
Van-der-waals ICL2 V 691 - s15s16 V 239 C.s15s16.01
Hydrophobic H8 Q 857 8x51 s5s6 V 66 N.s5s6.07
Polar ICL2 K 688 - S6 K 73 N.S6.03
Polar ICL2 V 691 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 V 691 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 V 691 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL3 P 781 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 P 781 - s5s6 L 69 N.s5s6.10
Polar H8 Q 857 8x51 s5s6 D 63 N.s5s6.04
Hydrophobic H8 Q 857 8x51 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 V 691 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 V 691 - s15s16 L 240 C.s15s16.02