S-arrestin - mGlu7 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
mGlu7 73.2
S-arrestin 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 I 683 3x57 S5 Y 71 N.S5.12
Van-der-waals H8 K 860 8x54 S5 A 68 N.S5.09
Polar ICL2 A 693 - s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 A 693 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 A 693 - s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 I 697 - s5s6 I 76 N.s5s6.05
Polar ICL2 R 695 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 R 695 - s8s9 Q 141 N.s8s9.05
Polar ICL2 S 690 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 S 690 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 S 690 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 V 691 - s8s9 Q 137 N.s8s9.01
Van-der-waals ICL2 V 691 - s8s9 Q 137 N.s8s9.01
Hydrophobic ICL3 P 781 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 P 781 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 R 679 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 679 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic C-term L 913 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term L 913 - s11s12 F 201 C.s11s12.02
Hydrophobic ICL2 G 687 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 687 - s8s9 K 145 N.s8s9.09
Aromatic H8 F 863 8x57 s7s8 Y 129 N.s7s8.05
Hydrophobic H8 F 863 8x57 s7s8 Y 129 N.s7s8.05
Van-der-waals H8 F 863 8x57 s7s8 Y 129 N.s7s8.05
Hydrophobic ICL2 V 691 - S8 L 136 N.S8.03
Van-der-waals ICL2 V 691 - S8 L 136 N.S8.03
Hydrophobic ICL2 T 692 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 T 692 - s8s9 P 138 N.s8s9.02
Polar H8 R 859 8x53 s9s10 A 163 N.s9s10.05
Hydrophobic H8 R 859 8x53 s9s10 A 163 N.s9s10.05
Van-der-waals H8 R 859 8x53 s9s10 A 163 N.s9s10.05
Polar ICL2 V 691 - s8s9 S 146 N.s8s9.10
Hydrophobic ICL2 V 691 - s8s9 S 146 N.s8s9.10
Van-der-waals ICL2 V 691 - s8s9 S 146 N.s8s9.10
Hydrophobic TM6 F 784 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 G 625 2x35 s5s6 I 79 N.s5s6.08
Polar TM3 Q 686 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 Q 686 3x60 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 Q 686 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 691 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 V 691 - s8s9 P 138 N.s8s9.02
Polar ICL1 A 623 12x52 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 A 623 12x52 s5s6 I 79 N.s5s6.08
Van-der-waals ICL1 A 623 12x52 s5s6 I 79 N.s5s6.08
Hydrophobic H8 F 863 8x57 S6 Y 88 N.S6.06
Polar ICL2 K 688 - S16 Y 259 C.S16.03
Hydrophobic ICL2 K 688 - S16 Y 259 C.S16.03
Hydrophobic ICL2 P 694 - s8s9 K 145 N.s8s9.09
Ionic H8 R 859 8x53 s9s10 E 165 N.s9s10.07
Polar H8 R 859 8x53 s9s10 E 165 N.s9s10.07
Hydrophobic H8 R 859 8x53 s9s10 E 165 N.s9s10.07
Van-der-waals H8 R 859 8x53 s9s10 E 165 N.s9s10.07
Ionic H8 K 860 8x54 S6 D 86 N.S6.04
Polar H8 K 860 8x54 S6 D 86 N.S6.04
Hydrophobic H8 K 860 8x54 S6 D 86 N.S6.04
Van-der-waals H8 K 860 8x54 S6 D 86 N.S6.04
Hydrophobic H8 S 862 8x56 S6 F 89 N.S6.07
Hydrophobic H8 F 863 8x57 S6 L 87 N.S6.05
Van-der-waals H8 F 863 8x57 S6 L 87 N.S6.05
Polar ICL2 K 688 - S16 D 257 C.S16.01
Hydrophobic ICL2 K 688 - S16 D 257 C.S16.01
Van-der-waals ICL2 K 688 - S16 D 257 C.S16.01
Hydrophobic ICL2 V 691 - s17s18 G 296 C.s17s18.12
Polar ICL2 G 687 - S16 Y 259 C.S16.03
Van-der-waals ICL2 G 687 - S16 Y 259 C.S16.03
Hydrophobic ICL2 T 692 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 T 692 - s8s9 G 144 N.s8s9.08
Hydrophobic ICL1 A 623 12x52 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 G 687 - S16 D 257 C.S16.01
Van-der-waals ICL2 G 687 - S16 D 257 C.S16.01
Polar ICL2 V 691 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 691 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 691 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 693 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 693 - s8s9 K 145 N.s8s9.09
Polar ICL2 K 689 - S16 Y 259 C.S16.03
Hydrophobic ICL2 K 689 - S16 Y 259 C.S16.03
Polar ICL2 V 691 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 691 - S16 Y 259 C.S16.03
Van-der-waals ICL2 V 691 - S16 Y 259 C.S16.03
Polar H8 K 860 8x54 S6 R 85 N.S6.03
Hydrophobic H8 K 860 8x54 S6 R 85 N.S6.03
Van-der-waals H8 K 860 8x54 S6 R 85 N.S6.03
Hydrophobic ICL2 A 693 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 A 693 - s5s6 Q 73 N.s5s6.02
Polar ICL2 T 692 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 T 692 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 692 - s8s9 K 145 N.s8s9.09
Polar ICL2 S 690 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 690 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 690 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 T 692 - s8s9 A 139 N.s8s9.03
Van-der-waals ICL2 T 692 - s8s9 A 139 N.s8s9.03
Aromatic TM6 F 784 6x33 S6 F 83 N.S6.01
Hydrophobic TM6 F 784 6x33 S6 F 83 N.S6.01
Van-der-waals TM6 F 784 6x33 S6 F 83 N.S6.01
Polar ICL2 T 692 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 T 692 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 T 692 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL1 R 622 12x51 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 F 784 6x33 s15s16 Y 254 C.s15s16.03
Polar H8 K 860 8x54 S5 F 69 N.S5.10
Polar ICL2 A 693 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 A 693 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 A 693 - s5s6 I 76 N.s5s6.05
Polar H8 K 860 8x54 S6 R 84 N.S6.02
Hydrophobic H8 K 860 8x54 S6 R 84 N.S6.02
Van-der-waals H8 K 860 8x54 S6 R 84 N.S6.02
Hydrophobic ICL2 T 692 - s8s9 S 143 N.s8s9.07
Hydrophobic TM4 P 699 4x29 s5s6 I 79 N.s5s6.08
Polar ICL2 S 690 - S16 Y 259 C.S16.03
Hydrophobic ICL2 S 690 - S16 Y 259 C.S16.03
Van-der-waals ICL2 S 690 - S16 Y 259 C.S16.03
Polar ICL2 G 687 - S5 Y 71 N.S5.12
Hydrophobic ICL2 G 687 - S5 Y 71 N.S5.12
Van-der-waals ICL2 G 687 - S5 Y 71 N.S5.12
Hydrophobic H8 R 859 8x53 s9s10 E 164 N.s9s10.06
Van-der-waals H8 R 859 8x53 s9s10 E 164 N.s9s10.06