S-arrestin - mGlu8 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
mGlu8 72.1
S-arrestin 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 F 777 6x33 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 F 777 6x33 s5s6 T 82 N.s5s6.11
Polar ICL2 A 686 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 A 686 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 A 686 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL1 R 615 12x51 s5s6 V 78 N.s5s6.07
Van-der-waals ICL1 R 615 12x51 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 F 777 6x33 s15s16 Y 254 C.s15s16.03
Polar ICL2 T 685 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 T 685 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 T 685 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 V 684 - s17s18 G 296 C.s17s18.12
Van-der-waals ICL2 V 684 - s17s18 G 296 C.s17s18.12
Hydrophobic ICL2 V 684 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 V 684 - s8s9 P 138 N.s8s9.02
Hydrophobic ICL2 T 685 - s8s9 A 139 N.s8s9.03
Hydrophobic H8 V 849 8x50 s9s10 D 166 N.s9s10.08
Van-der-waals H8 V 849 8x50 s9s10 D 166 N.s9s10.08
Van-der-waals H8 K 853 8x54 S5 A 68 N.S5.09
Polar H8 K 853 8x54 S5 F 69 N.S5.10
Van-der-waals H8 K 853 8x54 S5 F 69 N.S5.10
Hydrophobic ICL2 P 687 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 687 - s8s9 K 145 N.s8s9.09
Hydrophobic TM6 F 777 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 F 777 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 V 684 - S8 L 136 N.S8.03
Van-der-waals ICL2 V 684 - S8 L 136 N.S8.03
Polar H8 K 853 8x54 S6 R 84 N.S6.02
Hydrophobic H8 K 853 8x54 S6 R 84 N.S6.02
Van-der-waals H8 K 853 8x54 S6 R 84 N.S6.02
Polar H8 K 853 8x54 S6 R 85 N.S6.03
Hydrophobic H8 K 853 8x54 S6 R 85 N.S6.03
Van-der-waals H8 K 853 8x54 S6 R 85 N.S6.03
Hydrophobic H8 F 856 8x57 S6 Y 88 N.S6.06
Hydrophobic ICL2 A 686 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 686 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 686 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 A 686 - s8s9 G 144 N.s8s9.08
Hydrophobic H8 F 856 8x57 s17s18 V 324 C.s17s18.40
Van-der-waals H8 F 856 8x57 s17s18 V 324 C.s17s18.40
Polar ICL2 S 683 - S16 Y 259 C.S16.03
Hydrophobic ICL2 S 683 - S16 Y 259 C.S16.03
Van-der-waals ICL2 S 683 - S16 Y 259 C.S16.03
Hydrophobic ICL2 G 680 - S16 D 257 C.S16.01
Van-der-waals ICL2 G 680 - S16 D 257 C.S16.01
Hydrophobic TM4 P 692 4x29 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 G 618 2x35 s5s6 I 79 N.s5s6.08
Polar ICL2 S 683 - S16 D 257 C.S16.01
Hydrophobic C-term V 860 - s7s8 Y 129 N.s7s8.05
Aromatic TM6 F 777 6x33 S6 F 83 N.S6.01
Hydrophobic TM6 F 777 6x33 S6 F 83 N.S6.01
Van-der-waals TM6 F 777 6x33 S6 F 83 N.S6.01
Polar ICL2 G 680 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 G 680 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 G 680 - s15s16 S 255 C.s15s16.04
Hydrophobic TM6 F 777 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 F 777 6x33 s5s6 G 80 N.s5s6.09
Ionic H8 R 852 8x53 s9s10 E 165 N.s9s10.07
Polar H8 R 852 8x53 s9s10 E 165 N.s9s10.07
Hydrophobic H8 R 852 8x53 s9s10 E 165 N.s9s10.07
Van-der-waals H8 R 852 8x53 s9s10 E 165 N.s9s10.07
Hydrophobic ICL2 K 681 - s15s16 S 255 C.s15s16.04
Hydrophobic H8 F 856 8x57 s7s8 Y 129 N.s7s8.05
Van-der-waals H8 F 856 8x57 s7s8 Y 129 N.s7s8.05
Polar ICL2 S 683 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 683 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 683 - s8s9 K 145 N.s8s9.09
Polar ICL2 K 682 - S16 D 257 C.S16.01
Van-der-waals ICL2 K 682 - S16 D 257 C.S16.01
Hydrophobic ICL3 P 774 - s15s16 Y 254 C.s15s16.03
Hydrophobic H8 S 855 8x56 S6 F 89 N.S6.07
Polar TM3 I 676 3x57 S5 Y 71 N.S5.12
Polar H8 Q 850 8x51 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 F 677 3x58 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 F 677 3x58 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 K 682 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 684 - s8s9 Q 137 N.s8s9.01
Hydrophobic TM3 R 672 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 672 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 R 615 12x51 s5s6 I 79 N.s5s6.08
Van-der-waals ICL1 R 615 12x51 s5s6 I 79 N.s5s6.08
Hydrophobic H8 F 856 8x57 S6 L 87 N.S6.05
Van-der-waals H8 F 856 8x57 S6 L 87 N.S6.05
Polar ICL2 V 684 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 684 - S16 Y 259 C.S16.03
Van-der-waals ICL2 V 684 - S16 Y 259 C.S16.03
Hydrophobic ICL2 G 680 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 680 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 A 616 12x52 s5s6 G 80 N.s5s6.09
Ionic H8 K 853 8x54 S6 D 86 N.S6.04
Polar H8 K 853 8x54 S6 D 86 N.S6.04
Hydrophobic H8 K 853 8x54 S6 D 86 N.S6.04
Van-der-waals H8 K 853 8x54 S6 D 86 N.S6.04
Polar ICL2 K 681 - S16 D 257 C.S16.01
Hydrophobic ICL2 K 681 - S16 D 257 C.S16.01
Van-der-waals ICL2 K 681 - S16 D 257 C.S16.01
Polar ICL2 T 685 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 T 685 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 685 - s8s9 K 145 N.s8s9.09
Polar ICL1 A 616 12x52 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 A 616 12x52 s5s6 I 79 N.s5s6.08
Van-der-waals ICL1 A 616 12x52 s5s6 I 79 N.s5s6.08
Polar TM3 Q 679 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 Q 679 3x60 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 Q 679 3x60 s8s9 K 145 N.s8s9.09
Polar H8 F 856 8x57 S6 D 86 N.S6.04
Hydrophobic H8 F 856 8x57 S6 D 86 N.S6.04
Van-der-waals H8 F 856 8x57 S6 D 86 N.S6.04
Polar ICL2 V 684 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 684 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 684 - s8s9 K 145 N.s8s9.09
Polar ICL2 G 680 - S5 Y 71 N.S5.12
Hydrophobic ICL2 G 680 - S5 Y 71 N.S5.12
Van-der-waals ICL2 G 680 - S5 Y 71 N.S5.12
Hydrophobic TM3 R 672 3x53 s5s6 L 81 N.s5s6.10