Gi2 - mGlu8 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
mGlu8 75.9
Gαi2 89.6
Gβ1 93.7
Gγ2 85.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 615 12x51 G.H5 L 354 G.H5.25
Polar C-term S 904 - G.H2 R 209 G.H2.04
Hydrophobic TM6 F 777 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 F 777 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 672 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 672 3x53 G.H5 L 354 G.H5.25
Hydrophobic C-term I 908 - G.H3 I 254 G.H3.12
Hydrophobic ICL2 K 681 - G.S3 L 195 G.S3.01
Polar C-term N 905 - G.H2 E 208 G.H2.03
Hydrophobic C-term N 905 - G.H2 E 208 G.H2.03
Van-der-waals C-term N 905 - G.H2 E 208 G.H2.03
Hydrophobic C-term H 906 - G.s4h3 M 241 G.s4h3.14
Van-der-waals ICL1 R 615 12x51 G.H5 G 353 G.H5.24
Hydrophobic C-term I 908 - G.H3 L 250 G.H3.08
Van-der-waals C-term I 908 - G.H3 L 250 G.H3.08
Hydrophobic C-term I 908 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term I 908 - G.s1h1 G 40 G.s1h1.01
Polar C-term N 905 - G.H2 R 206 G.H2.01
Polar ICL2 A 686 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 686 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 686 - G.H5 N 348 G.H5.19
Polar C-term H 906 - G.H2 R 209 G.H2.04
Ionic H8 R 852 8x53 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 R 852 8x53 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 R 852 8x53 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 K 682 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 K 682 - G.S3 L 195 G.S3.01
Polar C-term K 857 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 V 684 - G.S1 E 33 G.S1.01
Hydrophobic ICL2 G 680 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 G 680 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 V 684 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 V 684 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 G 680 - G.H5 T 341 G.H5.12
Polar C-term I 908 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic ICL2 P 687 - G.H5 N 348 G.H5.19
Hydrophobic C-term I 908 - G.s3h2 G 203 G.s3h2.01
Van-der-waals C-term I 908 - G.s3h2 G 203 G.s3h2.01
Hydrophobic TM2 G 618 2x35 G.H5 L 354 G.H5.25
Van-der-waals TM2 G 618 2x35 G.H5 L 354 G.H5.25
Hydrophobic ICL2 I 690 - G.H5 C 352 G.H5.23
Polar H8 R 852 8x53 G.h4s6 K 315 G.h4s6.08
Hydrophobic H8 R 852 8x53 G.h4s6 K 315 G.h4s6.08
Van-der-waals H8 R 852 8x53 G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL2 K 681 - G.H5 T 341 G.H5.12
Polar C-term S 907 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term S 907 - G.H2 R 206 G.H2.01
Hydrophobic TM3 I 676 3x57 G.H5 N 348 G.H5.19
Hydrophobic C-term I 908 - G.S1 L 39 G.S1.07
Polar TM3 R 672 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 672 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 672 3x53 G.H5 C 352 G.H5.23
Hydrophobic C-term N 905 - G.H2 S 207 G.H2.02
Hydrophobic TM3 I 676 3x57 G.H5 C 352 G.H5.23
Polar ICL2 V 684 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 684 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 Q 850 8x51 G.H5 F 355 G.H5.26
Van-der-waals H8 Q 850 8x51 G.H5 F 355 G.H5.26
Ionic C-term H 906 - G.H3 E 246 G.H3.04
Polar C-term H 906 - G.H3 E 246 G.H3.04
Hydrophobic C-term H 906 - G.H3 E 246 G.H3.04
Van-der-waals C-term H 906 - G.H3 E 246 G.H3.04
Polar ICL2 T 685 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 685 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 685 - G.hns1 A 31 G.hns1.02
Hydrophobic H8 S 855 8x56 G.S6 Y 321 G.S6.02
Van-der-waals H8 S 855 8x56 G.S6 Y 321 G.S6.02
Hydrophobic ICL1 S 617 12x53 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 684 - G.H5 I 344 G.H5.15
Polar C-term I 908 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term I 908 - G.s3h2 G 204 G.s3h2.02
Hydrophobic TM3 I 676 3x57 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 676 3x57 G.H5 I 345 G.H5.16
Hydrophobic C-term I 908 - G.H2 R 209 G.H2.04
Van-der-waals C-term I 908 - G.H2 R 209 G.H2.04
Hydrophobic C-term I 908 - G.H2 W 212 G.H2.07
Hydrophobic ICL1 A 616 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 A 616 12x52 G.H5 L 354 G.H5.25
Polar H8 S 855 8x56 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 S 855 8x56 G.h4s6 E 319 G.h4s6.12
Van-der-waals H8 S 855 8x56 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 F 677 3x58 G.H5 I 345 G.H5.16
Van-der-waals TM3 F 677 3x58 G.H5 I 345 G.H5.16
Hydrophobic H8 F 856 8x57 G.H5 D 342 G.H5.13
Van-der-waals H8 F 856 8x57 G.H5 D 342 G.H5.13
Hydrophobic ICL2 G 680 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 S 683 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 S 683 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 T 685 - G.hns1 R 32 G.hns1.03
Hydrophobic C-term I 908 - G.H1 K 46 G.H1.01
Van-der-waals C-term I 908 - G.H1 K 46 G.H1.01
Hydrophobic C-term Y 903 - G.H3 S 253 G.H3.11
Van-der-waals C-term Y 903 - G.H3 S 253 G.H3.11
Ionic C-term K 857 - G.H5 D 338 G.H5.09
Polar C-term K 857 - G.H5 D 338 G.H5.09
Hydrophobic C-term K 857 - G.H5 D 338 G.H5.09
Van-der-waals C-term K 857 - G.H5 D 338 G.H5.09