S-arrestin - BB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
BB2 70.4
S-arrestin 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 M 146 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 M 146 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 146 34x51 S16 Y 259 C.S16.03
Hydrophobic TM2 N 76 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 76 2x40 s5s6 V 78 N.s5s6.07
Ionic TM6 H 251 6x22 S6 D 86 N.S6.04
Polar TM6 H 251 6x22 S6 D 86 N.S6.04
Hydrophobic TM6 H 251 6x22 S6 D 86 N.S6.04
Van-der-waals TM6 H 251 6x22 S6 D 86 N.S6.04
Hydrophobic TM2 P 75 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 K 254 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM5 L 244 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 L 244 5x72 S6 D 86 N.S6.04
Polar ICL2 M 146 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 M 146 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 M 146 34x51 s8s9 K 145 N.s8s9.09
Polar ICL2 P 145 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 145 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 145 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL3 P 245 - s7s8 Y 129 N.s7s8.05
Ionic H8 K 327 8x48 s9s10 D 166 N.s9s10.08
Polar H8 K 327 8x48 s9s10 D 166 N.s9s10.08
Polar TM6 R 259 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 259 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 259 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 H 251 6x22 S5 T 66 N.S5.07
Van-der-waals TM6 H 251 6x22 S5 T 66 N.S5.07
Polar ICL2 M 146 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 M 146 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 M 146 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 Q 149 34x54 s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 Q 149 34x54 s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 Q 149 34x54 s8s9 G 144 N.s8s9.08
Polar TM6 Q 255 6x26 S6 D 86 N.S6.04
Polar TM6 Q 255 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 Q 255 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 Q 255 6x26 S6 R 84 N.S6.02
Hydrophobic ICL2 M 146 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 M 146 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 I 142 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 I 142 3x54 s15s16 Y 254 C.s15s16.03
Polar ICL2 S 151 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 S 151 34x56 s8s9 D 142 N.s8s9.06
Polar ICL2 M 146 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 M 146 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 M 146 34x51 S16 D 257 C.S16.01
Hydrophobic TM3 I 142 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 142 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 T 265 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 265 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 266 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 266 6x37 s5s6 I 79 N.s5s6.08
Polar ICL2 D 147 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 D 147 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 D 147 34x52 S16 D 257 C.S16.01
Hydrophobic ICL1 M 71 12x50 s5s6 V 78 N.s5s6.07
Polar TM6 K 254 6x25 s9s10 A 163 N.s9s10.05
Hydrophobic TM6 K 254 6x25 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 K 254 6x25 s9s10 A 163 N.s9s10.05
Hydrophobic TM3 V 143 3x55 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 V 143 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 H 251 6x22 S6 F 89 N.S6.07
Hydrophobic TM6 L 262 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 262 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 145 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 145 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 262 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 262 6x33 s5s6 I 79 N.s5s6.08
Ionic TM6 H 251 6x22 s9s10 E 165 N.s9s10.07
Polar TM6 H 251 6x22 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 H 251 6x22 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 H 251 6x22 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 I 250 6x21 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 I 250 6x21 s9s10 A 163 N.s9s10.05
Polar TM6 Q 255 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 S 258 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 M 146 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 M 146 34x51 S8 L 136 N.S8.03
Hydrophobic ICL2 M 146 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 M 146 34x51 S9 C 147 N.S9.01
Hydrophobic TM6 L 262 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 L 262 6x33 s5s6 G 80 N.s5s6.09
Polar TM5 S 240 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 S 240 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 S 240 5x68 S6 R 85 N.S6.03
Hydrophobic TM3 R 144 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 138 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 138 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 P 75 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 P 75 2x39 s5s6 I 79 N.s5s6.08
Ionic TM6 K 254 6x25 s9s10 E 165 N.s9s10.07
Polar TM6 K 254 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 K 254 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 K 254 6x25 s9s10 E 165 N.s9s10.07
Polar ICL2 M 146 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 146 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 M 146 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL3 G 248 - S6 F 89 N.S6.07
Van-der-waals ICL3 G 248 - S6 F 89 N.S6.07
Hydrophobic TM3 L 134 3x46 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 244 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 L 244 5x72 S6 R 85 N.S6.03
Hydrophobic TM3 A 141 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 141 3x53 S6 F 83 N.S6.01
Polar H8 S 326 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 144 3x56 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 244 5x72 S6 L 87 N.S6.05
Polar H8 S 328 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 I 148 34x53 S5 Y 71 N.S5.12
Hydrophobic TM6 Q 255 6x26 S6 R 85 N.S6.03
Van-der-waals TM6 Q 255 6x26 S6 R 85 N.S6.03
Hydrophobic TM6 R 259 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 259 6x30 s5s6 L 81 N.s5s6.10
Polar TM2 N 73 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 N 73 2x37 s5s6 D 75 N.s5s6.04
Polar TM6 H 251 6x22 S6 R 84 N.S6.02
Hydrophobic TM6 H 251 6x22 S6 R 84 N.S6.02
Van-der-waals TM6 H 251 6x22 S6 R 84 N.S6.02
Polar ICL2 D 147 34x52 s8s9 K 145 N.s8s9.09
Polar ICL2 Q 149 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 149 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 149 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 I 148 34x53 s8s9 K 145 N.s8s9.09
Polar TM3 V 143 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 I 142 3x54 s5s6 L 81 N.s5s6.10
Polar ICL3 E 247 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM2 N 73 2x37 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 73 2x37 s5s6 V 78 N.s5s6.07