Arrestin-C - HCA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
HCA1 75.6
Arrestin-C 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 18.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL2 H 121 34x51 S16 D 244 C.S16.01
Polar ICL2 H 121 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 H 121 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 H 121 34x51 S16 D 244 C.S16.01
Ionic H8 K 287 8x52 s20c E 386 C.s20c.20
Polar H8 K 287 8x52 s20c E 386 C.s20c.20
Hydrophobic H8 K 287 8x52 s20c E 386 C.s20c.20
Van-der-waals H8 K 287 8x52 s20c E 386 C.s20c.20
Polar TM6 R 214 6x29 s5s6 T 70 N.s5s6.11
Ionic TM2 K 48 2x37 s5s6 D 62 N.s5s6.03
Polar TM2 K 48 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 K 48 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 K 48 2x37 s5s6 D 62 N.s5s6.03
Polar ICL1 K 45 - s20c K 378 C.s20c.11
Hydrophobic ICL3 L 209 - S6 F 71 N.S6.01
Van-der-waals ICL3 L 209 - S6 F 71 N.S6.01
Hydrophobic H8 P 283 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 P 283 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 K 116 3x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 K 116 3x53 s5s6 V 66 N.s5s6.07
Polar ICL2 H 121 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 H 121 34x51 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 H 121 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 V 117 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 A 210 - S6 F 71 N.S6.01
Hydrophobic ICL2 P 120 34x50 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 P 120 34x50 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 50 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 S 50 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 T 126 34x56 s8s9 A 133 N.s8s9.07
Polar H8 S 282 8x47 s5s6 E 65 N.s5s6.06
Polar TM7 S 281 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 S 281 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 S 281 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic C-term W 338 - s6h1 S 88 N.s6h1.05
Van-der-waals C-term W 338 - s6h1 S 88 N.s6h1.05
Hydrophobic TM3 K 116 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 K 116 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 M 215 6x30 s5s6 L 69 N.s5s6.10
Polar ICL2 H 121 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 H 121 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 203 5x65 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 R 214 6x29 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 R 214 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic TM7 F 280 7x55 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 F 280 7x55 s5s6 I 67 N.s5s6.08
Polar H8 K 287 8x52 s20c A 382 C.s20c.15
Van-der-waals H8 K 287 8x52 s20c A 382 C.s20c.15
Hydrophobic TM6 A 218 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 218 6x33 s5s6 L 69 N.s5s6.10
Ionic TM6 R 211 6x26 S6 D 74 N.S6.04
Hydrophobic TM5 L 203 5x65 s5s6 I 67 N.s5s6.08
Polar H8 K 287 8x52 s20c E 383 C.s20c.17
Van-der-waals H8 K 287 8x52 s20c E 383 C.s20c.17
Hydrophobic TM3 R 113 3x50 s5s6 I 67 N.s5s6.08
Polar ICL3 L 209 - S6 K 73 N.S6.03
Hydrophobic ICL3 L 209 - S6 K 73 N.S6.03
Van-der-waals ICL3 L 209 - S6 K 73 N.S6.03
Hydrophobic TM6 A 218 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 L 209 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 203 5x65 s5s6 L 69 N.s5s6.10
Polar ICL2 H 121 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 H 121 34x51 s8s9 A 133 N.s8s9.07
Polar TM6 R 214 6x29 s20c G 387 C.s20c.21
Van-der-waals TM6 R 214 6x29 s20c G 387 C.s20c.21
Polar ICL3 R 206 - s15s16 Y 241 C.s15s16.03
Aromatic ICL3 R 206 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 R 206 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 R 206 - s15s16 Y 241 C.s15s16.03
Polar TM7 F 280 7x55 s5s6 G 68 N.s5s6.09
Hydrophobic TM7 F 280 7x55 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 F 280 7x55 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 I 222 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 V 117 3x54 s5s6 L 64 N.s5s6.05
Polar TM3 R 113 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 113 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 113 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 L 209 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 L 209 - s15s16 L 240 C.s15s16.02
Hydrophobic TM7 S 281 7x56 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 S 281 7x56 s5s6 E 65 N.s5s6.06
Ionic TM2 K 48 2x37 s5s6 E 65 N.s5s6.06
Polar TM2 K 48 2x37 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 K 48 2x37 s5s6 E 65 N.s5s6.06