Beta-arrestin-2 - HCA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
HCA2 75.3
Beta-arrestin-2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 229 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 138 34x56 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 K 138 34x56 s8s9 T 137 N.s8s9.07
Polar TM3 R 125 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 125 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 125 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 H 133 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 H 133 34x51 S16 Y 250 C.S16.03
Polar TM7 F 296 7x55 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 F 296 7x55 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 F 296 7x55 s5s6 G 73 N.s5s6.09
Polar ICL2 H 133 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 133 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 H 133 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 K 60 2x37 s5s6 E 67 N.s5s6.03
Polar H8 N 310 8x59 s9s10 K 158 N.s9s10.09
Hydrophobic H8 N 310 8x59 s9s10 K 158 N.s9s10.09
Van-der-waals H8 N 310 8x59 s9s10 K 158 N.s9s10.09
Hydrophobic TM6 A 229 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 229 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 H 134 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 134 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 H 134 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 S 62 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 S 62 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 298 8x47 s5s6 G 73 N.s5s6.09
Hydrophobic ICL3 H 223 - S6 F 76 N.S6.01
Hydrophobic TM5 L 215 5x65 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 I 233 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 233 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 K 138 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 K 138 34x56 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 138 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 A 135 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 133 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 H 133 34x51 S16 A 248 C.S16.01
Hydrophobic TM6 I 226 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 125 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 226 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 I 226 6x30 S6 F 76 N.S6.01
Polar ICL2 H 133 34x51 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 H 133 34x51 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 H 133 34x51 s8s9 G 138 N.s8s9.08
Hydrophobic TM7 S 297 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 297 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 211 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 R 218 5x68 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 V 129 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 129 3x54 s5s6 L 72 N.s5s6.08
Polar TM7 S 297 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 S 297 7x56 s5s6 G 73 N.s5s6.09
Polar C-term Q 314 - s9s10 H 160 N.s9s10.11
Hydrophobic C-term Q 314 - s9s10 H 160 N.s9s10.11
Van-der-waals C-term Q 314 - s9s10 H 160 N.s9s10.11
Polar H8 S 306 8x55 s9s10 K 158 N.s9s10.09
Van-der-waals H8 S 306 8x55 s9s10 K 158 N.s9s10.09
Hydrophobic TM3 D 124 3x49 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 D 124 3x49 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 132 34x50 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 P 132 34x50 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 M 220 - S6 F 76 N.S6.01
Van-der-waals ICL3 M 220 - S6 F 76 N.S6.01
Hydrophobic TM6 K 225 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 225 6x29 s5s6 L 74 N.s5s6.10
Polar ICL2 K 138 34x56 s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 K 138 34x56 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 K 138 34x56 s8s9 P 134 N.s8s9.04
Hydrophobic TM3 V 129 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 V 129 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 P 132 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 132 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 132 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 132 34x50 s5s6 R 66 N.s5s6.02
Ionic ICL1 K 57 - s20c D 406 C.s20c.16
Polar ICL1 K 57 - s20c D 406 C.s20c.16
Van-der-waals ICL1 K 57 - s20c D 406 C.s20c.16
Hydrophobic TM5 L 215 5x65 s5s6 L 72 N.s5s6.08
Polar ICL2 K 138 34x56 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 K 138 34x56 s8s9 G 133 N.s8s9.03
Van-der-waals TM5 R 218 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 H 223 - s15s16 F 245 C.s15s16.03
Hydrophobic H8 P 299 8x48 s5s6 G 73 N.s5s6.09
Polar ICL2 H 133 34x51 s5s6 R 66 N.s5s6.02
Polar ICL2 K 138 34x56 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 K 138 34x56 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 K 138 34x56 s8s9 E 135 N.s8s9.05
Ionic TM3 R 128 3x53 s5s6 E 67 N.s5s6.03
Polar TM3 R 128 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 128 3x53 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 R 128 3x53 s5s6 E 67 N.s5s6.03
Ionic TM2 K 60 2x37 s5s6 D 70 N.s5s6.06
Polar TM2 K 60 2x37 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 K 60 2x37 s5s6 D 70 N.s5s6.06
Hydrophobic TM7 S 297 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 M 220 - s5s6 L 69 N.s5s6.05
Hydrophobic TM7 F 296 7x55 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 F 296 7x55 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 128 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 128 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 297 7x56 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 128 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 128 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 M 220 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 M 220 - s15s16 F 245 C.s15s16.03