Beta-arrestin-2 - H1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
H1 82.6
Beta-arrestin-2 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 413 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 413 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 133 34x51 S8 L 130 N.S8.03
Polar ICL2 P 132 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 132 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 132 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL3 V 402 - S6 I 82 N.S6.07
Van-der-waals ICL3 V 402 - S6 I 82 N.S6.07
Hydrophobic ICL2 L 133 34x51 S16 A 248 C.S16.01
Polar ICL3 Y 401 - s9s10 L 155 N.s9s10.03
Hydrophobic ICL3 Y 401 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 Y 401 - s9s10 L 155 N.s9s10.03
Polar ICL2 R 139 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 139 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 139 34x57 s5s6 R 66 N.s5s6.02
Polar TM5 H 223 5x71 S6 K 78 N.S6.03
Hydrophobic ICL3 Y 401 - s9s10 E 156 N.s9s10.07
Hydrophobic TM3 V 129 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 213 5x61 s5s6 L 74 N.s5s6.10
Aromatic TM5 H 220 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 H 220 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 H 220 5x68 S6 F 76 N.S6.01
Polar TM5 R 224 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 R 224 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 R 224 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 V 217 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 V 217 5x65 s5s6 L 74 N.s5s6.10
Ionic TM6 R 409 6x29 S6 D 79 N.S6.04
Hydrophobic TM3 R 125 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 125 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic H8 N 472 8x47 s5s6 V 71 N.s5s6.07
Ionic H8 K 477 8x52 s20c D 405 C.s20c.15
Hydrophobic TM5 R 224 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 I 227 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 I 227 5x75 S6 K 78 N.S6.03
Polar TM6 Q 416 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 Q 416 6x36 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Q 416 6x36 s5s6 G 73 N.s5s6.09
Polar TM6 R 409 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 409 6x29 S6 R 77 N.S6.02
Ionic ICL2 R 139 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 139 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 139 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 139 34x57 s5s6 D 68 N.s5s6.04
Polar ICL1 K 57 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 57 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 57 12x49 s20c D 402 C.s20c.12
Polar TM6 Q 416 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 L 231 - S6 L 80 N.S6.05
Van-der-waals ICL3 L 231 - S6 L 80 N.S6.05
Hydrophobic ICL2 L 133 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 133 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 S 128 3x53 s5s6 L 69 N.s5s6.05
Aromatic TM5 H 220 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 220 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 220 5x68 s15s16 F 245 C.s15s16.03
Polar ICL2 L 133 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 133 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 133 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 V 129 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 129 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 K 412 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 L 417 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 417 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 133 34x51 S9 C 141 N.S9.01
Hydrophobic TM5 R 224 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 R 224 5x72 S6 K 78 N.S6.03
Polar ICL2 L 133 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 133 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 133 34x51 S5 Y 64 N.S5.12
Hydrophobic TM3 V 129 3x54 s5s6 L 74 N.s5s6.10
Polar ICL1 K 57 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 R 56 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 56 12x48 s20c K 400 C.s20c.10
Hydrophobic TM2 T 60 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 60 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 I 420 6x40 s5s6 L 72 N.s5s6.08
Ionic ICL1 R 56 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 56 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 56 12x48 s20c D 402 C.s20c.12
Polar H8 N 474 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 N 474 8x49 s5s6 E 67 N.s5s6.03
Polar TM5 R 224 5x72 s5s6 S 75 N.s5s6.11
Van-der-waals TM5 R 224 5x72 s5s6 S 75 N.s5s6.11
Polar ICL2 L 136 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 136 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 136 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 A 413 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 413 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 133 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 133 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL1 K 57 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM3 V 129 3x54 S6 F 76 N.S6.01
Hydrophobic TM7 C 471 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 C 471 7x56 s5s6 V 71 N.s5s6.07
Ionic TM5 H 223 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 I 213 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 125 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 R 134 34x52 s15s16 T 247 C.s15s16.05
Ionic TM4 K 141 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 K 141 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 141 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 141 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 R 134 34x52 S16 A 248 C.S16.01
Hydrophobic TM6 Q 416 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 Q 416 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 132 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 136 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM5 R 224 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 R 224 5x72 S6 F 76 N.S6.01
Aromatic H8 R 481 8x56 s20c Y 404 C.s20c.14
Hydrophobic TM5 Y 210 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 137 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 K 137 34x55 S16 Y 250 C.S16.03