Beta-arrestin-1 - H2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
H2 75.0
Beta-arrestin-1 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM7 L 291 7x56 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 W 222 6x23 S6 V 81 N.S6.07
Polar ICL2 P 127 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 127 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 P 127 34x54 s8s9 T 136 N.s8s9.07
Aromatic ICL2 Y 126 34x53 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 Y 126 34x53 s8s9 K 138 N.s8s9.09
Polar H8 Q 301 8x56 s20c E 407 C.s20c.17
Ionic TM6 R 228 6x29 S6 D 78 N.S6.04
Polar TM2 N 51 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 51 2x37 s5s6 D 67 N.s5s6.04
Polar TM3 D 122 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 D 122 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 D 122 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 123 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 123 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 A 232 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 232 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 L 124 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 124 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 124 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 L 236 6x37 s5s6 L 73 N.s5s6.10
Ionic ICL1 R 48 12x49 s20c E 407 C.s20c.17
Polar ICL1 R 48 12x49 s20c E 407 C.s20c.17
Hydrophobic ICL1 R 48 12x49 s20c E 407 C.s20c.17
Hydrophobic H8 D 294 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 D 294 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 124 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 124 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 I 216 5x72 S6 R 76 N.S6.02
Hydrophobic TM2 T 53 2x39 s5s6 L 68 N.s5s6.05
Polar ICL2 P 123 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 123 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 123 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 I 216 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 I 216 5x72 S6 K 77 N.S6.03
Polar ICL2 P 123 34x50 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 P 123 34x50 s8s9 K 138 N.s8s9.09
Hydrophobic TM6 R 228 6x29 S6 R 76 N.S6.02
Van-der-waals TM6 R 228 6x29 S6 R 76 N.S6.02
Hydrophobic TM6 K 231 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 L 236 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 236 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 124 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 124 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 I 219 - S6 K 77 N.S6.03
Van-der-waals ICL3 I 219 - S6 K 77 N.S6.03
Hydrophobic TM5 Y 202 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 W 222 6x23 S6 N 83 N.S6.09
Van-der-waals TM6 W 222 6x23 S6 N 83 N.S6.09
Hydrophobic ICL2 R 125 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 125 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 116 3x50 s5s6 L 68 N.s5s6.05
Polar ICL2 Y 126 34x53 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Y 126 34x53 s8s9 T 136 N.s8s9.07
Polar TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 124 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 124 34x51 S16 A 247 C.S16.01
Hydrophobic TM3 M 121 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 M 121 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 I 219 - S6 L 79 N.S6.05
Van-der-waals ICL3 I 219 - S6 L 79 N.S6.05
Ionic TM6 K 231 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 K 231 6x32 s5s6 D 69 N.s5s6.06
Polar TM7 L 291 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 L 291 7x56 s5s6 L 71 N.s5s6.08
Ionic TM6 K 223 6x24 s9s10 E 155 N.s9s10.07
Polar TM6 K 223 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic TM6 K 223 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 K 223 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 V 128 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 V 128 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 W 222 6x23 s9s10 L 154 N.s9s10.03
Van-der-waals TM6 W 222 6x23 s9s10 L 154 N.s9s10.03
Hydrophobic ICL3 I 219 - s17s18 I 314 C.s17s18.40
Van-der-waals TM6 A 232 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 116 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 N 51 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 N 51 2x37 s5s6 R 65 N.s5s6.02
Polar TM7 L 291 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 L 291 7x56 s5s6 G 72 N.s5s6.09
Polar H8 N 292 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 292 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 292 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 127 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 P 127 34x54 s8s9 D 135 N.s8s9.06
Ionic TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM3 V 120 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 120 3x54 S6 F 75 N.S6.01
Polar ICL2 L 124 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 124 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 124 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 124 34x51 s8s9 G 137 N.s8s9.08
Polar TM6 R 228 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 228 6x29 s5s6 T 74 N.s5s6.11
Polar ICL2 L 124 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 124 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 124 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 I 205 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals ICL2 P 123 34x50 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 116 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 116 3x50 s5s6 V 70 N.s5s6.07
Ionic ICL1 R 48 12x49 s20c E 404 C.s20c.14
Polar ICL1 R 48 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 R 48 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 R 48 12x49 s20c E 404 C.s20c.14
Hydrophobic TM6 V 239 6x40 s5s6 L 71 N.s5s6.08
Polar TM6 T 235 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 235 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 235 6x36 s5s6 L 71 N.s5s6.08
Polar ICL1 R 48 12x49 s20c K 403 C.s20c.13
Hydrophobic ICL1 R 48 12x49 s20c K 403 C.s20c.13
Van-der-waals ICL1 R 48 12x49 s20c K 403 C.s20c.13
Polar H8 N 292 8x47 s5s6 D 67 N.s5s6.04
Van-der-waals H8 N 292 8x47 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 A 209 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 209 5x65 s5s6 L 73 N.s5s6.10
Polar TM3 A 119 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 A 119 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 A 119 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM5 R 215 5x71 S6 K 77 N.S6.03
Hydrophobic ICL2 L 124 34x51 s15s16 T 246 C.s15s16.05