Beta-arrestin-2 - H3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
H3 78.2
Beta-arrestin-2 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 143 34x54 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 R 143 34x54 s8s9 K 139 N.s8s9.09
Hydrophobic ICL3 T 345 - S6 R 77 N.S6.02
Van-der-waals ICL3 T 345 - S6 R 77 N.S6.02
Hydrophobic TM6 V 356 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 356 6x33 s5s6 L 72 N.s5s6.08
Polar TM6 D 353 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 D 353 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM3 S 135 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 136 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 356 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 Q 342 - S6 I 82 N.S6.07
Hydrophobic ICL2 R 143 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM6 R 349 6x26 S6 K 78 N.S6.03
Van-der-waals TM6 R 349 6x26 S6 K 78 N.S6.03
Polar TM6 R 352 6x29 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 R 352 6x29 s5s6 L 69 N.s5s6.05
Polar ICL2 V 140 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 140 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 140 34x51 S16 Y 250 C.S16.03
Aromatic ICL2 R 143 34x54 S5 Y 64 N.S5.12
Hydrophobic ICL2 R 143 34x54 S5 Y 64 N.S5.12
Van-der-waals ICL2 R 143 34x54 S5 Y 64 N.S5.12
Van-der-waals TM6 R 349 6x26 s5s6 S 75 N.s5s6.11
Ionic H8 R 421 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 V 136 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 146 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 146 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 Q 146 34x57 s5s6 D 68 N.s5s6.04
Polar TM5 R 228 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 228 5x68 S6 F 76 N.S6.01
Polar ICL2 V 140 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 140 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 140 34x51 s15s16 S 246 C.s15s16.04
Polar ICL2 S 141 34x52 s15s16 T 247 C.s15s16.05
Polar ICL1 S 63 12x48 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 S 63 12x48 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 S 63 12x48 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 R 143 34x54 s5s6 G 65 N.s5s6.01
Polar ICL2 R 143 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 143 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 143 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 V 140 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 V 140 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 S 141 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 S 141 34x52 S16 A 248 C.S16.01
Hydrophobic TM6 V 356 6x33 s5s6 G 73 N.s5s6.09
Polar ICL2 Q 146 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 146 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 146 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 R 232 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 R 232 5x72 S6 F 76 N.S6.01
Polar ICL2 A 139 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 V 140 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 V 140 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 V 140 34x51 S5 Y 64 N.S5.12
Polar TM2 T 67 2x37 s5s6 D 68 N.s5s6.04
Polar TM3 R 138 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 138 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 R 138 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 S 341 - S6 I 82 N.S6.07
Van-der-waals ICL3 S 341 - S6 I 82 N.S6.07
Polar ICL2 A 144 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 A 144 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 A 144 34x55 S16 Y 250 C.S16.03
Polar ICL3 T 345 - S6 D 79 N.S6.04
Hydrophobic ICL3 T 345 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 345 - S6 D 79 N.S6.04
Polar TM2 N 69 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 R 349 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 R 349 6x26 S6 F 76 N.S6.01
Polar TM3 R 132 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 D 353 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 D 353 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 V 340 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 V 340 - s9s10 L 155 N.s9s10.03
Hydrophobic H8 H 416 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 H 416 8x47 s5s6 V 71 N.s5s6.07
Polar C-term Q 435 - s20c Q 407 C.s20c.17
Van-der-waals C-term Q 435 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 R 143 34x54 S9 C 141 N.S9.01
Ionic TM6 R 352 6x29 s5s6 D 70 N.s5s6.06
Polar TM6 R 352 6x29 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 R 352 6x29 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 352 6x29 s5s6 D 70 N.s5s6.06
Polar H8 R 421 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 R 421 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 R 421 8x52 s20c Y 404 C.s20c.14
Hydrophobic TM3 R 132 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 132 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 S 135 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 V 340 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 V 340 - s9s10 E 156 N.s9s10.07
Polar TM6 R 352 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 352 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 352 6x29 s5s6 L 74 N.s5s6.10
Ionic H8 H 417 8x48 s5s6 E 67 N.s5s6.03
Polar TM6 R 349 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 R 349 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 R 349 6x26 S6 R 77 N.S6.02
Hydrophobic TM3 R 132 3x50 s5s6 V 71 N.s5s6.07
Polar TM6 R 352 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 352 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 352 6x29 s5s6 S 75 N.s5s6.11
Polar ICL2 A 139 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 139 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 139 34x50 S5 Y 64 N.S5.12
Polar ICL2 S 141 34x52 s15s16 S 246 C.s15s16.04
Polar ICL1 S 64 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 S 64 12x49 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 S 64 12x49 s8s9 E 135 N.s8s9.05
Polar H8 R 421 8x52 s8s9 T 137 N.s8s9.07
Hydrophobic H8 R 421 8x52 s8s9 T 137 N.s8s9.07
Van-der-waals H8 R 421 8x52 s8s9 T 137 N.s8s9.07
Polar TM6 R 352 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 352 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 352 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 V 140 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 140 34x51 S16 A 248 C.S16.01