Arrestin-C - H3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
H3 82.1
Arrestin-C 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 349 6x26 s15s16 L 243 C.s15s16.05
Hydrophobic ICL3 V 340 - S6 K 73 N.S6.03
Aromatic TM6 F 348 6x25 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 F 348 6x25 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 F 348 6x25 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 S 341 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 S 341 - s17s18 L 311 C.s17s18.40
Hydrophobic ICL3 F 344 - S6 K 73 N.S6.03
Van-der-waals ICL3 F 344 - S6 K 73 N.S6.03
Ionic H8 H 417 8x48 s8s9 D 132 N.s8s9.06
Hydrophobic C-term L 432 - s8s9 E 131 N.s8s9.05
Polar ICL3 S 341 - S6 K 73 N.S6.03
Hydrophobic ICL3 S 341 - S6 K 73 N.S6.03
Van-der-waals ICL3 S 341 - S6 K 73 N.S6.03
Polar C-term Q 435 - s17s18 R 282 C.s17s18.11
Van-der-waals C-term Q 435 - s17s18 R 282 C.s17s18.11
Aromatic H8 H 417 8x48 s5s6 R 61 N.s5s6.02
Polar ICL3 T 345 - S6 K 73 N.S6.03
Hydrophobic TM6 R 352 6x29 s15s16 L 243 C.s15s16.05
Van-der-waals TM6 R 352 6x29 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 R 143 34x54 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 143 34x54 s15s16 L 243 C.s15s16.05
Polar ICL3 T 345 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 T 345 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 T 345 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 F 344 - S6 R 72 N.S6.02
Ionic H8 R 421 8x52 s8s9 E 131 N.s8s9.05
Polar H8 R 421 8x52 s8s9 E 131 N.s8s9.05
Hydrophobic H8 R 421 8x52 s8s9 E 131 N.s8s9.05
Van-der-waals H8 R 421 8x52 s8s9 E 131 N.s8s9.05
Ionic TM6 K 355 6x32 s5s6 D 63 N.s5s6.04
Ionic TM6 R 349 6x26 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 F 348 6x25 s15s16 S 242 C.s15s16.04
Van-der-waals TM6 F 348 6x25 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 F 348 6x25 S6 F 71 N.S6.01
Hydrophobic TM6 F 348 6x25 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 T 345 - s15s16 L 240 C.s15s16.02
Ionic H8 K 425 8x56 s8s9 E 131 N.s8s9.05
Polar H8 K 425 8x56 s8s9 E 131 N.s8s9.05
Hydrophobic H8 K 425 8x56 s8s9 E 131 N.s8s9.05
Van-der-waals H8 K 425 8x56 s8s9 E 131 N.s8s9.05
Aromatic ICL3 F 344 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 F 344 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 F 344 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 F 344 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 F 344 - s15s16 L 240 C.s15s16.02