Beta-arrestin-1 - H4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
H4 79.0
Beta-arrestin-1 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic H8 K 367 8x52 s20c E 407 C.s20c.17
Polar H8 K 367 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 367 8x52 s20c E 407 C.s20c.17
Hydrophobic ICL2 T 124 34x55 s17s18 G 286 C.s17s18.12
Hydrophobic TM5 L 201 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 201 5x65 s5s6 L 73 N.s5s6.10
Polar TM5 Q 211 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 Q 211 5x75 S6 K 77 N.S6.03
Hydrophobic TM6 L 305 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 305 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 201 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 201 5x65 S6 F 75 N.S6.01
Hydrophobic TM3 S 115 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 S 115 3x53 s5s6 L 68 N.s5s6.05
Polar H8 H 362 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 H 362 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 H 362 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 T 124 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 T 124 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 T 124 34x55 S16 Y 249 C.S16.03
Hydrophobic TM7 Y 358 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 A 119 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 L 301 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 301 6x33 s5s6 L 71 N.s5s6.08
Polar TM3 S 117 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 S 117 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 S 117 3x55 s15s16 N 245 C.s15s16.04
Ionic ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM5 I 197 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 C 361 7x56 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Q 211 5x75 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 Q 211 5x75 s17s18 I 314 C.s17s18.40
Polar TM6 R 297 6x29 s5s6 T 74 N.s5s6.11
Polar ICL2 R 123 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 R 123 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 123 34x54 s8s9 K 138 N.s8s9.09
Polar TM5 Q 211 5x75 s17s18 N 311 C.s17s18.37
Hydrophobic TM5 Q 211 5x75 s17s18 N 311 C.s17s18.37
Van-der-waals TM5 Q 211 5x75 s17s18 N 311 C.s17s18.37
Hydrophobic ICL2 T 124 34x55 S8 L 129 N.S8.03
Ionic ICL2 H 126 - s8s9 E 134 N.s8s9.05
Polar ICL2 H 126 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 H 126 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 H 126 - s8s9 E 134 N.s8s9.05
Polar TM5 R 204 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 204 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 204 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic H8 H 362 8x47 s5s6 D 69 N.s5s6.06
Ionic H8 K 363 8x48 s5s6 D 69 N.s5s6.06
Polar H8 K 363 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 363 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 363 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 L 301 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 301 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 R 123 34x54 s8s9 A 139 N.s8s9.10
Polar TM5 L 207 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 L 207 5x71 S6 K 77 N.S6.03
Ionic H8 R 364 8x49 s5s6 D 67 N.s5s6.04
Polar H8 R 364 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 R 364 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 123 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 123 34x54 s8s9 P 131 N.s8s9.02
Polar H8 R 364 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic H8 R 364 8x49 s8s9 T 136 N.s8s9.07
Van-der-waals H8 R 364 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 R 204 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 204 5x68 S6 F 75 N.S6.01
Ionic TM2 H 48 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 H 48 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 H 48 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 H 48 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 V 116 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 116 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 H 126 - s17s18 R 285 C.s17s18.11
Aromatic ICL2 H 126 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 H 126 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 H 126 - s17s18 R 285 C.s17s18.11
Polar ICL2 V 120 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 120 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 V 120 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 120 34x51 S16 A 247 C.S16.01
Polar ICL2 A 119 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 119 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 119 34x50 S5 Y 63 N.S5.12
Polar TM3 N 118 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 N 118 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 120 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 V 120 34x51 S8 L 129 N.S8.03
Hydrophobic ICL2 R 123 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 S 208 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 S 208 5x72 S6 K 77 N.S6.03
Hydrophobic TM7 C 361 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 C 361 7x56 s5s6 V 70 N.s5s6.07
Polar ICL3 Q 289 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 Q 289 - s9s10 L 154 N.s9s10.03
Polar H8 H 362 8x47 s5s6 D 67 N.s5s6.04
Hydrophobic H8 H 362 8x47 s5s6 D 67 N.s5s6.04
Van-der-waals H8 H 362 8x47 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 V 120 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 120 34x51 S15 I 241 C.S15.14
Ionic ICL3 R 290 - S6 D 78 N.S6.04
Polar ICL3 R 290 - S6 D 78 N.S6.04
Hydrophobic ICL3 R 290 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 290 - S6 D 78 N.S6.04
Polar ICL2 V 120 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 V 120 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 120 34x51 S16 Y 249 C.S16.03
Hydrophobic TM5 R 204 5x68 S5 Y 63 N.S5.12
Polar ICL3 R 290 - S6 R 76 N.S6.02
Polar ICL3 Q 289 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 Q 289 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 Q 289 - s9s10 E 155 N.s9s10.07
Hydrophobic TM6 S 304 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 304 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 F 54 2x43 s5s6 V 70 N.s5s6.07
Polar ICL2 S 121 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 S 121 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 S 121 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL3 R 290 - S6 K 77 N.S6.03
Van-der-waals ICL3 R 290 - S6 K 77 N.S6.03
Polar ICL2 R 123 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 R 123 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 123 34x54 s8s9 G 137 N.s8s9.08
Ionic H8 K 367 8x52 s20c E 405 C.s20c.15
Polar H8 K 367 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 K 367 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 K 367 8x52 s20c E 405 C.s20c.15
Hydrophobic ICL3 A 286 - S6 V 81 N.S6.07
Hydrophobic TM3 V 116 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 V 116 3x54 s5s6 L 73 N.s5s6.10
Polar TM5 Q 211 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 Q 211 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM3 R 112 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 112 3x50 s5s6 V 70 N.s5s6.07