Beta-arrestin-2 - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
kisspeptin 74.7
Beta-arrestin-2 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM2 T 75 2x37 s8s9 T 137 N.s8s9.07
Polar ICL2 R 154 34x57 s5s6 R 66 N.s5s6.02
Ionic TM5 R 237 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 R 237 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 237 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 237 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 Y 224 5x58 s5s6 L 72 N.s5s6.08
Polar TM5 R 237 5x71 S6 K 78 N.S6.03
Hydrophobic TM3 R 140 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 140 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 T 75 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 75 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 154 34x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 231 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 M 227 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 M 227 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 P 240 5x74 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 P 240 5x74 s17s18 V 315 C.s17s18.40
Hydrophobic TM6 L 250 6x22 S6 I 82 N.S6.07
Van-der-waals TM6 L 250 6x22 S6 I 82 N.S6.07
Hydrophobic TM6 L 264 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 264 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 L 151 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 151 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 151 34x54 s5s6 R 66 N.s5s6.02
Ionic H8 H 329 8x49 s5s6 E 67 N.s5s6.03
Polar H8 H 329 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 H 329 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 H 329 8x49 s5s6 E 67 N.s5s6.03
Polar TM6 K 260 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 260 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 260 6x32 s5s6 G 73 N.s5s6.09
Polar C-term C 389 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 389 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 389 - s17s18 R 286 C.s17s18.11
Polar C-term V 390 - S16 K 251 C.S16.04
Van-der-waals C-term V 390 - S16 K 251 C.S16.04
Hydrophobic ICL2 L 148 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 148 34x51 S15 I 242 C.S15.14
Polar ICL2 H 152 34x55 S16 Y 250 C.S16.03
Aromatic ICL2 H 152 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 H 152 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 H 152 34x55 S16 Y 250 C.S16.03
Hydrophobic TM3 V 143 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 143 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 M 227 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic C-term C 389 - S16 K 251 C.S16.04
Van-der-waals C-term C 389 - S16 K 251 C.S16.04
Ionic ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 R 253 6x25 S6 I 82 N.S6.07
Van-der-waals TM6 R 253 6x25 S6 I 82 N.S6.07
Hydrophobic TM5 V 234 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 234 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 V 257 6x29 s5s6 L 74 N.s5s6.10
Polar TM2 T 77 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 77 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 L 148 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 151 34x54 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 151 34x54 S5 Y 64 N.S5.12
Hydrophobic TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 Q 246 5x80 S6 F 81 N.S6.06
Van-der-waals TM5 Q 246 5x80 S6 F 81 N.S6.06
Hydrophobic TM2 T 77 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 77 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 151 34x54 s5s6 G 65 N.s5s6.01
Hydrophobic C-term L 391 - S16 A 248 C.S16.01
Polar C-term G 392 - S16 Q 249 C.S16.02
Van-der-waals C-term G 392 - S16 Q 249 C.S16.02
Hydrophobic ICL2 L 148 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 148 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 P 240 5x74 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 A 239 5x73 s17s18 V 315 C.s17s18.40
Hydrophobic TM6 V 249 6x21 S6 I 82 N.S6.07
Hydrophobic TM3 T 144 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 T 144 3x54 S6 F 76 N.S6.01
Ionic TM6 R 253 6x25 S6 D 79 N.S6.04
Polar TM6 R 253 6x25 S6 D 79 N.S6.04
Van-der-waals TM6 R 253 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 L 250 6x22 S6 L 80 N.S6.05
Polar H8 S 328 8x48 s5s6 D 70 N.s5s6.06
Polar C-term C 389 - S16 C 252 C.S16.05
Hydrophobic C-term C 389 - S16 C 252 C.S16.05
Van-der-waals C-term C 389 - S16 C 252 C.S16.05
Hydrophobic C-term C 389 - s17s18 K 285 C.s17s18.10
Hydrophobic TM3 T 144 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 143 3x53 S6 F 76 N.S6.01
Van-der-waals TM3 V 143 3x53 S6 F 76 N.S6.01
Polar ICL2 L 148 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 148 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 148 34x51 S5 Y 64 N.S5.12
Polar H8 R 336 8x56 s20c Y 404 C.s20c.14
Aromatic H8 R 336 8x56 s20c Y 404 C.s20c.14
Hydrophobic H8 R 336 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 R 336 8x56 s20c Y 404 C.s20c.14
Hydrophobic C-term C 389 - s17s18 G 287 C.s17s18.12
Ionic H8 H 329 8x49 s5s6 D 70 N.s5s6.06
Polar H8 H 329 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 H 329 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 H 329 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 P 147 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals C-term L 391 - S16 Q 249 C.S16.02
Hydrophobic C-term L 391 - S16 Y 250 C.S16.03
Van-der-waals C-term L 391 - S16 Y 250 C.S16.03
Hydrophobic ICL2 L 148 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 148 34x51 S16 A 248 C.S16.01
Polar ICL2 P 147 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 147 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 147 34x50 S5 Y 64 N.S5.12
Hydrophobic TM6 L 250 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 L 250 6x22 S6 D 79 N.S6.04
Polar TM5 V 234 5x68 S6 K 78 N.S6.03
Hydrophobic TM5 V 234 5x68 S6 K 78 N.S6.03
Polar TM5 Q 246 5x80 S6 I 82 N.S6.07
Hydrophobic TM5 Q 246 5x80 S6 I 82 N.S6.07
Van-der-waals TM5 Q 246 5x80 S6 I 82 N.S6.07
Polar TM2 V 76 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 V 261 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 261 6x33 s5s6 L 74 N.s5s6.10