ArrestinDb

Arrestin-C - kisspeptin receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
kisspeptin	73.8
Arrestin-C	81.9

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.7

PAE mean: 15.0

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	H	152	34x55	s8s9	K	135	N.s8s9.09
Hydrophobic	TM2	T	77	2x39	s5s6	L	64	N.s5s6.05
Hydrophobic	TM3	R	140	3x50	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	L	148	34x51	s15s16	L	240	C.s15s16.02
Hydrophobic	C-term	R	343	-	s20c	E	386	C.s20c.20
Hydrophobic	TM3	V	143	3x53	S6	F	71	N.S6.01
Hydrophobic	ICL2	L	148	34x51	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM3	T	144	3x54	s5s6	L	69	N.s5s6.10
Hydrophobic	TM6	V	261	6x33	s5s6	L	69	N.s5s6.10
Hydrophobic	TM5	P	240	5x74	s17s18	L	311	C.s17s18.40
Hydrophobic	TM5	V	234	5x68	s15s16	Y	241	C.s15s16.03
Hydrophobic	C-term	R	344	-	s20c	D	385	C.s20c.19
Hydrophobic	TM6	L	250	6x22	S6	L	75	N.S6.05
Hydrophobic	H8	R	336	8x56	s20c	E	383	C.s20c.17
Hydrophobic	TM5	M	227	5x61	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	P	147	34x50	S5	Y	59	N.S5.12
Hydrophobic	ICL2	L	148	34x51	S15	V	238	C.S15.14
Hydrophobic	C-term	R	344	-	s20c	S	388	C.s20c.22
Hydrophobic	TM5	Y	224	5x58	s5s6	I	67	N.s5s6.08
Hydrophobic	TM6	V	257	6x29	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	H	152	34x55	S16	Y	246	C.S16.03
Hydrophobic	TM5	P	240	5x74	s17s18	D	308	C.s17s18.37
Hydrophobic	H8	H	329	8x49	s5s6	D	63	N.s5s6.04
Hydrophobic	TM5	A	239	5x73	s17s18	L	311	C.s17s18.40
Hydrophobic	TM3	V	143	3x53	s5s6	V	66	N.s5s6.07
Hydrophobic	TM2	T	77	2x39	s5s6	V	66	N.s5s6.07
Hydrophobic	TM2	T	75	2x37	s5s6	D	63	N.s5s6.04
Hydrophobic	TM5	D	242	5x76	s7s8	V	117	N.s7s8.03
Hydrophobic	C-term	L	363	-	ns1	M	1	N.ns1.13
Hydrophobic	ICL2	H	152	34x55	s8s9	K	135	N.s8s9.09
Hydrophobic	TM6	L	264	6x36	s5s6	I	67	N.s5s6.08
Hydrophobic	C-term	R	344	-	s20c	E	386	C.s20c.20
Hydrophobic	TM5	L	231	5x65	s5s6	L	69	N.s5s6.10
Hydrophobic	TM6	V	249	6x21	S6	V	77	N.S6.07
Hydrophobic	ICL2	L	148	34x51	S5	Y	59	N.S5.12
Hydrophobic	TM6	L	250	6x22	S6	D	74	N.S6.04
Hydrophobic	ICL2	L	151	34x54	s8s9	G	134	N.s8s9.08
Hydrophobic	TM5	M	227	5x61	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	L	148	34x51	S16	D	244	C.S16.01
Hydrophobic	TM6	K	260	6x32	s5s6	G	68	N.s5s6.09
Hydrophobic	ICL2	P	147	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM6	V	265	6x37	s5s6	I	67	N.s5s6.08
Hydrophobic	H8	S	328	8x48	s5s6	E	65	N.s5s6.06
Hydrophobic	TM5	Q	246	5x80	S6	Y	76	N.S6.06
Hydrophobic	H8	H	329	8x49	s5s6	D	62	N.s5s6.03
Hydrophobic	TM6	R	253	6x25	S6	V	77	N.S6.07
Hydrophobic	H8	H	329	8x49	s5s6	E	65	N.s5s6.06
Hydrophobic	ICL2	L	148	34x51	s15s16	S	242	C.s15s16.04
Hydrophobic	TM6	L	264	6x36	s5s6	G	68	N.s5s6.09
Hydrophobic	ICL2	L	151	34x54	s8s9	K	135	N.s8s9.09
Hydrophobic	TM6	L	250	6x22	S6	V	77	N.S6.07
Hydrophobic	TM6	R	253	6x25	s9s10	E	152	N.s9s10.07
Hydrophobic	TM2	T	75	2x37	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	H	152	34x55	s8s9	D	132	N.s8s9.06
Hydrophobic	TM6	R	253	6x25	S5	M	52	N.S5.05
Hydrophobic	TM3	R	140	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM5	Q	246	5x80	S6	V	77	N.S6.07
Hydrophobic	ICL2	L	151	34x54	s5s6	G	60	N.s5s6.01
Hydrophobic	TM5	V	234	5x68	S6	K	73	N.S6.03
Ionic	TM5	R	237	5x71	s17s18	E	310	C.s17s18.39
Ionic	C-term	R	344	-	s20c	D	385	C.s20c.19
Ionic	H8	R	336	8x56	s20c	E	383	C.s20c.17
Ionic	TM6	K	260	6x32	s5s6	E	65	N.s5s6.06
Ionic	TM6	R	253	6x25	S6	D	74	N.S6.04
Ionic	TM1	H	70	1x60	s20c	E	383	C.s20c.17
Ionic	H8	H	329	8x49	s5s6	E	65	N.s5s6.06
Ionic	TM6	R	253	6x25	s9s10	E	152	N.s9s10.07
Ionic	ICL2	H	152	34x55	s8s9	D	132	N.s8s9.06
Polar	TM5	R	237	5x71	s17s18	E	310	C.s17s18.39
Polar	C-term	R	344	-	s20c	D	385	C.s20c.19
Polar	H8	R	336	8x56	s20c	E	383	C.s20c.17
Polar	C-term	R	344	-	s20c	S	388	C.s20c.22
Polar	TM6	K	260	6x32	s5s6	E	65	N.s5s6.06
Polar	ICL2	H	152	34x55	S16	Y	246	C.S16.03
Polar	ICL2	H	152	34x55	s8s9	K	135	N.s8s9.09
Polar	C-term	R	344	-	s20c	E	386	C.s20c.20
Polar	TM6	R	253	6x25	S6	D	74	N.S6.04
Polar	TM6	K	260	6x32	s5s6	G	68	N.s5s6.09
Polar	H8	S	328	8x48	s5s6	E	65	N.s5s6.06
Polar	H8	H	329	8x49	s5s6	D	62	N.s5s6.03
Polar	ICL1	R	74	12x51	s5s6	R	61	N.s5s6.02
Polar	H8	H	329	8x49	s5s6	E	65	N.s5s6.06
Polar	ICL2	L	151	34x54	s8s9	K	135	N.s8s9.09
Polar	TM6	R	253	6x25	s9s10	E	152	N.s9s10.07
Polar	ICL2	H	152	34x55	s8s9	D	132	N.s8s9.06
Polar	TM5	Q	246	5x80	S6	V	77	N.S6.07
Van-der-waals	TM2	T	77	2x39	s5s6	L	64	N.s5s6.05
Van-der-waals	TM3	R	140	3x50	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL2	L	148	34x51	s15s16	L	240	C.s15s16.02
Van-der-waals	TM5	R	237	5x71	s17s18	E	310	C.s17s18.39
Van-der-waals	C-term	R	343	-	s20c	E	386	C.s20c.20
Van-der-waals	TM3	V	143	3x53	S6	F	71	N.S6.01
Van-der-waals	ICL1	P	72	12x49	s5s6	D	63	N.s5s6.04
Van-der-waals	TM6	V	261	6x33	s5s6	L	69	N.s5s6.10
Van-der-waals	TM5	P	240	5x74	s17s18	L	311	C.s17s18.40
Van-der-waals	C-term	R	344	-	s20c	D	385	C.s20c.19
Van-der-waals	TM6	L	250	6x22	S6	L	75	N.S6.05
Van-der-waals	H8	R	336	8x56	s20c	E	383	C.s20c.17
Van-der-waals	ICL2	P	147	34x50	S5	Y	59	N.S5.12
Van-der-waals	ICL2	L	148	34x51	S15	V	238	C.S15.14
Van-der-waals	C-term	R	344	-	s20c	S	388	C.s20c.22
Van-der-waals	TM5	Y	224	5x58	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	H	152	34x55	S16	Y	246	C.S16.03
Van-der-waals	H8	H	329	8x49	s5s6	D	63	N.s5s6.04
Van-der-waals	H8	Q	332	8x52	s9s10	K	157	N.s9s10.12
Van-der-waals	TM5	D	242	5x76	s7s8	V	117	N.s7s8.03
Van-der-waals	C-term	L	363	-	ns1	M	1	N.ns1.13
Van-der-waals	ICL2	H	152	34x55	s8s9	K	135	N.s8s9.09
Van-der-waals	TM6	L	264	6x36	s5s6	I	67	N.s5s6.08
Van-der-waals	TM5	L	231	5x65	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	L	148	34x51	S16	D	244	C.S16.01
Van-der-waals	TM6	K	260	6x32	s5s6	G	68	N.s5s6.09
Van-der-waals	ICL2	P	147	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	H8	S	328	8x48	s5s6	E	65	N.s5s6.06
Van-der-waals	TM5	Q	246	5x80	S6	Y	76	N.S6.06
Van-der-waals	H8	H	329	8x49	s5s6	D	62	N.s5s6.03
Van-der-waals	TM6	R	253	6x25	S6	V	77	N.S6.07
Van-der-waals	H8	H	329	8x49	s5s6	E	65	N.s5s6.06
Van-der-waals	ICL2	L	148	34x51	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	L	151	34x54	s8s9	K	135	N.s8s9.09
Van-der-waals	TM6	R	253	6x25	s9s10	E	152	N.s9s10.07
Van-der-waals	TM6	R	253	6x25	S5	M	52	N.S5.05
Van-der-waals	TM3	R	140	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	TM5	Q	246	5x80	S6	V	77	N.S6.07
Van-der-waals	ICL2	L	151	34x54	s5s6	G	60	N.s5s6.01

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Main reference

Arrestin-C - kisspeptin receptor complex model Download Full