Beta-arrestin-2 - LPA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA1 79.1
Beta-arrestin-2 81.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 Q 154 34x51 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 154 34x51 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 154 34x51 s5s6 R 66 N.s5s6.02
Ionic ICL3 H 242 - s17s18 E 314 C.s17s18.39
Hydrophobic TM5 M 239 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 M 239 5x72 s15s16 L 244 C.s15s16.02
Hydrophobic TM3 R 146 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 146 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 L 155 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 155 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 155 34x52 S16 Y 250 C.S16.03
Aromatic ICL2 H 156 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 H 156 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic ICL1 R 79 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 F 82 2x37 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 F 82 2x37 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 V 150 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 150 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 155 34x52 S15 I 242 C.S15.14
Van-der-waals ICL2 L 155 34x52 S15 I 242 C.S15.14
Hydrophobic ICL3 S 243 - S6 K 78 N.S6.03
Van-der-waals ICL3 S 243 - S6 K 78 N.S6.03
Hydrophobic TM3 V 150 3x54 s5s6 L 72 N.s5s6.08
Polar ICL3 H 242 - s17s18 N 312 C.s17s18.37
Hydrophobic ICL3 H 242 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 H 242 - s17s18 N 312 C.s17s18.37
Polar ICL2 M 153 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 153 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 153 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 H 156 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL3 H 242 - S6 K 78 N.S6.03
Polar TM5 M 239 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 M 239 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 M 239 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 M 239 5x72 s15s16 F 245 C.s15s16.03
Polar TM5 R 235 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 R 235 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 235 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 235 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 V 232 5x65 S6 F 76 N.S6.01
Hydrophobic TM5 V 232 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 154 34x51 S5 Y 64 N.S5.12
Polar TM6 S 255 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 S 255 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic C-term I 352 - s19s20 D 384 C.s19s20.50
Van-der-waals C-term I 352 - s19s20 D 384 C.s19s20.50
Polar ICL2 L 155 34x52 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 155 34x52 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 155 34x52 S5 Y 64 N.S5.12
Hydrophobic TM5 Y 225 5x58 s5s6 L 72 N.s5s6.08
Polar ICL2 H 156 34x53 s8s9 G 133 N.s8s9.03
Hydrophobic ICL2 H 156 34x53 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 H 156 34x53 s8s9 G 133 N.s8s9.03
Hydrophobic ICL3 H 242 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 H 242 - s17s18 V 315 C.s17s18.40
Polar ICL2 H 156 34x53 s8s9 Q 131 N.s8s9.01
Hydrophobic ICL2 H 156 34x53 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 H 156 34x53 s8s9 Q 131 N.s8s9.01
Hydrophobic TM3 T 149 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 T 149 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 M 153 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 M 153 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 M 239 5x72 S6 F 76 N.S6.01
Hydrophobic ICL3 S 243 - S6 D 79 N.S6.04
Van-der-waals ICL3 S 243 - S6 D 79 N.S6.04
Hydrophobic TM2 M 88 2x43 s5s6 V 71 N.s5s6.07
Polar ICL2 T 157 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 157 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 157 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals TM5 R 235 5x68 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 Y 85 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 85 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 G 245 6x22 S6 I 82 N.S6.07
Hydrophobic TM6 T 252 6x29 S6 F 76 N.S6.01
Hydrophobic ICL1 R 79 12x49 s20c Y 404 C.s20c.14
Polar TM6 T 252 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 T 252 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 T 252 6x29 s5s6 S 75 N.s5s6.11
Polar ICL1 R 79 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 79 12x49 s20c D 402 C.s20c.12
Polar ICL3 S 244 - S6 L 80 N.S6.05
Polar TM3 R 146 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 146 3x50 s5s6 V 71 N.s5s6.07
Ionic ICL2 H 156 34x53 s8s9 D 136 N.s8s9.06
Polar ICL2 H 156 34x53 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 H 156 34x53 s8s9 D 136 N.s8s9.06
Hydrophobic TM3 T 149 3x53 s5s6 L 69 N.s5s6.05
Polar ICL3 S 244 - S6 D 79 N.S6.04
Hydrophobic ICL2 L 155 34x52 S8 L 130 N.S8.03
Van-der-waals ICL2 L 155 34x52 S8 L 130 N.S8.03
Hydrophobic ICL2 H 156 34x53 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 H 156 34x53 s8s9 P 132 N.s8s9.02
Hydrophobic ICL2 H 156 34x53 s5s6 R 66 N.s5s6.02
Polar ICL2 H 156 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic ICL2 H 156 34x53 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 H 156 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic TM6 R 248 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 R 248 6x25 S6 R 77 N.S6.02
Polar ICL2 L 155 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 155 34x52 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 155 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 L 256 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 232 5x65 s15s16 F 245 C.s15s16.03
Polar ICL2 M 153 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 153 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 153 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 I 84 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 I 84 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 155 34x52 S9 C 141 N.S9.01
Van-der-waals ICL2 L 155 34x52 S9 C 141 N.S9.01
Ionic TM6 R 248 6x25 S6 D 79 N.S6.04
Polar TM6 R 248 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 R 248 6x25 S6 D 79 N.S6.04
Van-der-waals TM6 R 248 6x25 S6 D 79 N.S6.04
Hydrophobic ICL2 L 155 34x52 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 L 155 34x52 s8s9 A 140 N.s8s9.10
Polar TM6 T 259 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 259 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 259 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 150 3x54 s5s6 L 69 N.s5s6.05