Beta-arrestin-1 - LPA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA2 81.7
Beta-arrestin-1 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 130 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 130 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 M 219 5x72 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 M 219 5x72 s15s16 L 243 C.s15s16.02
Polar ICL2 H 136 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 H 136 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 H 136 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 H 222 - s17s18 I 314 C.s17s18.40
Hydrophobic ICL2 H 136 34x53 s17s18 G 286 C.s17s18.12
Hydrophobic TM6 H 226 6x23 S6 D 78 N.S6.04
Polar ICL2 L 135 34x52 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 135 34x52 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 135 34x52 S5 Y 63 N.S5.12
Ionic TM6 R 228 6x25 S6 D 78 N.S6.04
Polar TM6 R 228 6x25 S6 D 78 N.S6.04
Van-der-waals TM6 R 228 6x25 S6 D 78 N.S6.04
Hydrophobic ICL3 V 223 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 223 - S6 D 78 N.S6.04
Hydrophobic TM6 Y 229 6x26 S6 K 77 N.S6.03
Van-der-waals TM6 Y 229 6x26 S6 K 77 N.S6.03
Polar ICL2 S 137 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 S 137 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 S 137 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 T 232 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 236 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 236 6x33 s5s6 L 73 N.s5s6.10
Ionic ICL3 H 222 - s17s18 E 313 C.s17s18.39
Polar ICL3 H 222 - s17s18 E 313 C.s17s18.39
Hydrophobic ICL3 H 222 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL3 H 222 - s17s18 E 313 C.s17s18.39
Polar TM3 R 126 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 126 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 126 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 V 130 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 H 136 34x53 s8s9 G 132 N.s8s9.03
Ionic H8 R 301 8x52 s20c E 405 C.s20c.15
Polar H8 R 301 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 R 301 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 R 301 8x52 s20c E 405 C.s20c.15
Hydrophobic TM2 Y 65 2x40 s5s6 V 70 N.s5s6.07
Polar ICL2 V 133 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 V 133 34x50 S5 Y 63 N.S5.12
Polar TM3 S 129 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 S 129 3x53 s5s6 R 65 N.s5s6.02
Polar ICL3 H 222 - s17s18 N 311 C.s17s18.37
Hydrophobic TM6 R 228 6x25 S6 R 76 N.S6.02
Van-der-waals TM6 R 228 6x25 S6 R 76 N.S6.02
Hydrophobic TM5 M 219 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 Y 205 5x58 s5s6 L 71 N.s5s6.08
Polar TM6 T 232 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 T 232 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 T 232 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 L 135 34x52 S9 C 140 N.S9.01
Van-der-waals ICL2 L 135 34x52 S9 C 140 N.S9.01
Hydrophobic TM6 T 232 6x29 S6 F 75 N.S6.01
Hydrophobic TM3 V 130 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 236 6x33 s5s6 L 71 N.s5s6.08
Polar TM6 S 235 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 S 235 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 S 235 6x32 s5s6 G 72 N.s5s6.09
Polar TM5 M 219 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 M 219 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 M 219 5x72 S6 K 77 N.S6.03
Van-der-waals TM2 Q 62 2x37 s8s9 G 137 N.s8s9.08
Polar ICL2 Q 134 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 V 212 5x65 s5s6 L 73 N.s5s6.10
Polar ICL1 R 59 12x49 s20c K 403 C.s20c.13
Hydrophobic ICL1 R 59 12x49 s20c K 403 C.s20c.13
Van-der-waals ICL1 R 59 12x49 s20c K 403 C.s20c.13
Hydrophobic TM5 V 216 5x69 S6 F 75 N.S6.01
Polar TM5 R 215 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 R 215 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 215 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 215 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 V 133 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 I 64 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 R 59 12x49 s20c E 404 C.s20c.14
Polar TM5 R 215 5x68 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 R 215 5x68 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 R 215 5x68 s15s16 N 245 C.s15s16.04
Polar ICL2 V 133 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 133 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 133 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 H 136 34x53 S16 Y 249 C.S16.03
Hydrophobic ICL2 H 136 34x53 S16 Y 249 C.S16.03
Van-der-waals ICL2 H 136 34x53 S16 Y 249 C.S16.03
Hydrophobic TM2 L 68 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 135 34x52 S8 L 129 N.S8.03
Hydrophobic ICL3 V 223 - S6 K 77 N.S6.03
Van-der-waals ICL3 V 223 - S6 K 77 N.S6.03
Hydrophobic ICL2 H 136 34x53 S8 L 129 N.S8.03
Ionic ICL2 H 136 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 136 34x53 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 136 34x53 s8s9 D 135 N.s8s9.06
Polar ICL2 L 135 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 135 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 135 34x52 S16 Y 249 C.S16.03
Hydrophobic TM3 R 126 3x50 s5s6 L 71 N.s5s6.08
Polar ICL1 R 59 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 R 59 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 59 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 135 34x52 S15 I 241 C.S15.14
Polar ICL2 Q 134 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 134 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 134 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic TM2 I 64 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 V 212 5x65 S6 F 75 N.S6.01
Hydrophobic ICL3 V 223 - S6 L 79 N.S6.05
Polar ICL2 L 135 34x52 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 135 34x52 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 135 34x52 s5s6 R 65 N.s5s6.02
Polar TM3 S 129 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 S 129 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 S 129 3x53 s5s6 D 67 N.s5s6.04
Polar TM2 Q 62 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 Q 62 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 Q 62 2x37 s5s6 E 66 N.s5s6.03
Polar TM6 T 239 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 239 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 239 6x36 s5s6 L 71 N.s5s6.08
Polar TM2 Q 62 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 Q 62 2x37 s8s9 T 136 N.s8s9.07
Polar ICL2 H 136 34x53 s8s9 Q 130 N.s8s9.01
Hydrophobic ICL2 H 136 34x53 s8s9 Q 130 N.s8s9.01
Van-der-waals ICL2 H 136 34x53 s8s9 Q 130 N.s8s9.01
Polar ICL2 H 136 34x53 s8s9 P 131 N.s8s9.02
Hydrophobic ICL2 H 136 34x53 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 H 136 34x53 s8s9 P 131 N.s8s9.02
Ionic ICL1 R 59 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 59 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 59 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 59 12x49 s20c D 402 C.s20c.12
Hydrophobic TM6 H 226 6x23 S6 V 81 N.S6.07