Arrestin-C - LPA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA3 76.8
Arrestin-C 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 137 34x53 S8 L 126 N.S8.03
Van-der-waals TM6 R 230 6x26 S6 L 75 N.S6.05
Polar TM3 S 130 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 S 130 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 F 63 2x37 s8s9 D 132 N.s8s9.06
Polar TM3 S 130 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 S 130 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 V 213 5x65 s5s6 L 69 N.s5s6.10
Polar ICL2 V 136 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 V 136 34x52 S16 Y 246 C.S16.03
Hydrophobic TM2 L 69 2x43 s5s6 V 66 N.s5s6.07
Polar ICL2 R 135 34x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 135 34x51 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 135 34x51 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 F 63 2x37 s8s9 E 131 N.s8s9.05
Van-der-waals TM2 F 63 2x37 s8s9 E 131 N.s8s9.05
Hydrophobic TM5 L 220 5x72 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 L 220 5x72 s15s16 L 240 C.s15s16.02
Polar TM6 L 237 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 L 237 6x33 s5s6 G 68 N.s5s6.09
Polar ICL2 R 135 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 R 135 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 R 135 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL3 H 223 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 H 223 - s17s18 L 311 C.s17s18.40
Polar TM6 R 230 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 R 230 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 R 230 6x26 S6 D 74 N.S6.04
Polar TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 M 134 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 M 134 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL2 V 136 34x52 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 136 34x52 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 136 34x52 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 136 34x52 S9 C 137 N.S9.01
Van-der-waals ICL2 V 136 34x52 S9 C 137 N.S9.01
Hydrophobic H8 D 297 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 297 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 R 230 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 R 230 6x26 S6 K 73 N.S6.03
Polar H8 K 306 8x56 s20c E 383 C.s20c.17
Van-der-waals H8 K 306 8x56 s20c E 383 C.s20c.17
Polar ICL2 M 134 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 M 134 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 M 134 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 M 134 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 M 134 34x50 S6 F 71 N.S6.01
Ionic TM5 K 216 5x68 s17s18 E 310 C.s17s18.39
Polar TM5 K 216 5x68 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 K 216 5x68 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 216 5x68 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 L 237 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 237 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 L 220 5x72 s17s18 E 310 C.s17s18.39
Ionic ICL2 H 137 34x53 s8s9 D 132 N.s8s9.06
Polar ICL2 H 137 34x53 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 H 137 34x53 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 H 137 34x53 s8s9 D 132 N.s8s9.06
Polar TM5 K 216 5x68 s15s16 V 239 C.s15s16.01
Hydrophobic ICL3 T 224 - s17s18 L 311 C.s17s18.40
Hydrophobic TM2 F 63 2x37 s8s9 A 133 N.s8s9.07
Van-der-waals TM2 F 63 2x37 s8s9 A 133 N.s8s9.07
Polar ICL2 V 136 34x52 S5 Y 59 N.S5.12
Hydrophobic ICL2 V 136 34x52 S5 Y 59 N.S5.12
Van-der-waals ICL2 V 136 34x52 S5 Y 59 N.S5.12
Hydrophobic TM6 T 233 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 T 233 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 S 138 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 138 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 M 134 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 M 134 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 M 134 34x50 S5 Y 59 N.S5.12
Hydrophobic TM6 S 227 6x23 S6 V 77 N.S6.07
Polar ICL2 S 138 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic TM2 Y 66 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 Y 66 2x40 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 F 65 2x39 s5s6 D 63 N.s5s6.04
Polar TM6 R 232 6x28 s9s10 T 154 N.s9s10.09
Hydrophobic TM5 K 216 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 220 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic ICL2 V 136 34x52 S8 L 126 N.S8.03
Hydrophobic TM2 F 65 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 F 65 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 H 137 34x53 s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 H 137 34x53 s8s9 P 128 N.s8s9.02
Polar TM6 S 227 6x23 S6 D 74 N.S6.04
Hydrophobic TM6 S 227 6x23 S6 D 74 N.S6.04
Polar ICL2 H 137 34x53 s8s9 Q 127 N.s8s9.01
Hydrophobic ICL2 H 137 34x53 s8s9 Q 127 N.s8s9.01
Van-der-waals ICL2 H 137 34x53 s8s9 Q 127 N.s8s9.01
Hydrophobic TM3 I 131 3x54 s5s6 I 67 N.s5s6.08
Polar ICL2 V 136 34x52 S16 D 244 C.S16.01
Hydrophobic TM3 I 131 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 131 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 F 65 2x39 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 H 137 34x53 s17s18 R 282 C.s17s18.11
Ionic ICL2 R 135 34x51 S16 D 244 C.S16.01
Polar ICL2 R 135 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 R 135 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 R 135 34x51 S16 D 244 C.S16.01
Polar ICL2 H 137 34x53 S16 Y 246 C.S16.03
Aromatic ICL2 H 137 34x53 S16 Y 246 C.S16.03
Hydrophobic ICL2 H 137 34x53 S16 Y 246 C.S16.03
Van-der-waals ICL2 H 137 34x53 S16 Y 246 C.S16.03
Hydrophobic ICL3 T 224 - S6 L 75 N.S6.05
Van-der-waals ICL3 T 224 - S6 L 75 N.S6.05
Hydrophobic TM6 I 228 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 I 228 6x24 s9s10 E 152 N.s9s10.07
Polar TM4 K 142 4x39 s8s9 E 131 N.s8s9.05
Polar ICL2 H 137 34x53 s17s18 G 283 C.s17s18.12
Hydrophobic ICL2 H 137 34x53 s17s18 G 283 C.s17s18.12
Van-der-waals ICL2 H 137 34x53 s17s18 G 283 C.s17s18.12
Polar TM5 K 216 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 K 216 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 V 213 5x65 S6 F 71 N.S6.01
Hydrophobic TM6 L 237 6x33 s5s6 I 67 N.s5s6.08
Polar TM5 T 217 5x69 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 T 240 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 127 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 131 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 V 136 34x52 S15 V 238 C.S15.14
Polar ICL2 S 138 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 S 138 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 S 130 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 S 130 3x53 s5s6 L 64 N.s5s6.05
Polar ICL2 H 137 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 H 137 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 137 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 L 220 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 L 220 5x72 S6 K 73 N.S6.03