S-arrestin - LPA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA3 77.1
S-arrestin 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 213 5x65 S6 F 83 N.S6.01
Hydrophobic ICL2 V 136 34x52 S9 C 147 N.S9.01
Van-der-waals ICL2 V 136 34x52 S9 C 147 N.S9.01
Polar ICL2 H 137 34x53 S16 Y 259 C.S16.03
Hydrophobic ICL2 H 137 34x53 S16 Y 259 C.S16.03
Polar ICL2 V 136 34x52 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 136 34x52 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 136 34x52 S5 Y 71 N.S5.12
Hydrophobic TM3 I 131 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 131 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 V 241 6x37 s5s6 I 79 N.s5s6.08
Polar ICL2 S 138 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 138 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 138 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 137 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 137 34x53 s8s9 K 145 N.s8s9.09
Polar ICL3 T 224 - S6 R 85 N.S6.03
Hydrophobic ICL3 T 224 - S6 R 85 N.S6.03
Van-der-waals ICL3 T 224 - S6 R 85 N.S6.03
Polar ICL3 T 224 - S6 D 86 N.S6.04
Polar ICL2 V 136 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 136 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 136 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL3 H 223 - s17s18 D 321 C.s17s18.37
Hydrophobic TM2 F 63 2x37 s8s9 Q 141 N.s8s9.05
Van-der-waals TM2 F 63 2x37 s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 V 136 34x52 S15 V 251 C.S15.14
Hydrophobic ICL3 T 224 - S6 L 87 N.S6.05
Van-der-waals ICL3 T 224 - S6 L 87 N.S6.05
Polar ICL2 M 134 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 134 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 M 134 34x50 S5 Y 71 N.S5.12
Hydrophobic TM5 I 209 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 F 63 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 F 63 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 127 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 F 65 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 V 136 34x52 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 136 34x52 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 220 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 L 220 5x72 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 Y 206 5x58 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 Y 206 5x58 s5s6 I 79 N.s5s6.08
Polar TM6 R 230 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 R 230 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 R 230 6x26 S6 R 84 N.S6.02
Ionic TM6 R 232 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 R 232 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 232 6x28 s9s10 D 166 N.s9s10.08
Polar TM5 L 220 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 L 220 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 L 220 5x72 S6 R 85 N.S6.03
Ionic TM6 R 230 6x26 S6 D 86 N.S6.04
Polar TM6 R 230 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 R 230 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 R 230 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 L 237 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 237 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 L 220 5x72 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 L 220 5x72 s17s18 T 323 C.s17s18.39
Polar ICL2 R 135 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 135 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 135 34x51 S5 Y 71 N.S5.12
Ionic ICL2 H 137 34x53 s8s9 D 142 N.s8s9.06
Polar ICL2 H 137 34x53 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 H 137 34x53 s8s9 D 142 N.s8s9.06
Polar TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 127 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 T 233 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 T 233 6x29 s5s6 T 82 N.s5s6.11
Ionic TM6 R 232 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 232 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 232 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 232 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 230 6x26 S5 F 69 N.S5.10
Van-der-waals TM6 R 230 6x26 S5 F 69 N.S5.10
Polar ICL2 H 137 34x53 s8s9 Q 137 N.s8s9.01
Hydrophobic TM3 I 131 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 213 5x65 s5s6 L 81 N.s5s6.10
Ionic TM6 K 236 6x32 s9s10 D 166 N.s9s10.08
Ionic ICL1 K 60 12x49 s20c E 395 C.s20c.14
Polar ICL1 K 60 12x49 s20c E 395 C.s20c.14
Hydrophobic ICL1 K 60 12x49 s20c E 395 C.s20c.14
Van-der-waals ICL1 K 60 12x49 s20c E 395 C.s20c.14
Polar ICL2 M 134 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 M 134 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 M 134 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 M 134 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 M 134 34x50 s15s16 Y 254 C.s15s16.03
Polar TM5 K 216 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 216 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 216 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 V 136 34x52 S8 L 136 N.S8.03
Hydrophobic ICL3 T 224 - s17s18 V 324 C.s17s18.40
Hydrophobic TM3 I 131 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 H 137 34x53 s8s9 P 138 N.s8s9.02
Polar TM6 S 229 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 S 229 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 S 229 6x25 s9s10 E 165 N.s9s10.07
Polar TM6 S 227 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 S 227 6x23 S6 D 86 N.S6.04
Ionic H8 D 299 8x49 s20c R 398 C.s20c.17
Polar H8 D 299 8x49 s20c R 398 C.s20c.17
Hydrophobic H8 D 299 8x49 s20c R 398 C.s20c.17
Van-der-waals H8 D 299 8x49 s20c R 398 C.s20c.17
Hydrophobic TM2 F 63 2x37 s8s9 D 142 N.s8s9.06
Polar ICL3 H 223 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL2 H 137 34x53 s8s9 A 139 N.s8s9.03
Polar ICL2 H 137 34x53 s17s18 G 296 C.s17s18.12
Polar TM6 R 230 6x26 S6 R 85 N.S6.03
Hydrophobic TM6 R 230 6x26 S6 R 85 N.S6.03
Van-der-waals TM6 R 230 6x26 S6 R 85 N.S6.03
Van-der-waals ICL2 M 134 34x50 S16 D 257 C.S16.01
Hydrophobic TM6 G 226 6x22 S6 F 89 N.S6.07
Hydrophobic TM6 R 230 6x26 S5 A 68 N.S5.09
Van-der-waals TM6 R 230 6x26 S5 A 68 N.S5.09
Ionic ICL2 R 135 34x51 S16 D 257 C.S16.01
Polar ICL2 R 135 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 R 135 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 R 135 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 L 237 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 237 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 H 223 - s17s18 V 324 C.s17s18.40