S-arrestin - LPA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA4 74.7
S-arrestin 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 M 70 12x50 s5s6 E 74 N.s5s6.03
Van-der-waals ICL1 M 70 12x50 s5s6 E 74 N.s5s6.03
Hydrophobic TM3 I 140 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 140 3x54 s5s6 I 79 N.s5s6.08
Polar TM6 I 240 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 I 240 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 I 240 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 V 247 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 247 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 K 246 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 246 6x32 s5s6 G 80 N.s5s6.09
Polar TM4 R 152 4x39 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 152 4x39 s8s9 Q 141 N.s8s9.05
Polar TM6 G 241 6x27 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 G 241 6x27 s5s6 T 82 N.s5s6.11
Ionic H8 H 327 8x59 s20c E 405 C.s20c.24
Hydrophobic H8 H 327 8x59 s20c E 405 C.s20c.24
Van-der-waals H8 H 327 8x59 s20c E 405 C.s20c.24
Hydrophobic TM6 I 240 6x26 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 T 74 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 74 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 Q 239 6x25 S6 R 84 N.S6.02
Van-der-waals TM6 Q 239 6x25 S6 R 84 N.S6.02
Polar TM6 Q 239 6x25 S6 R 85 N.S6.03
Hydrophobic TM6 Q 239 6x25 S6 R 85 N.S6.03
Van-der-waals TM6 Q 239 6x25 S6 R 85 N.S6.03
Polar ICL2 R 150 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 150 34x57 s8s9 K 145 N.s8s9.09
Polar TM6 G 241 6x27 S6 R 84 N.S6.02
Van-der-waals TM6 G 241 6x27 S6 R 84 N.S6.02
Hydrophobic TM3 I 140 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals ICL2 F 144 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 P 143 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 143 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 143 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 147 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 147 34x54 S16 Y 259 C.S16.03
Polar TM4 R 152 4x39 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 I 240 6x26 s5s6 T 82 N.s5s6.11
Aromatic ICL2 F 144 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 144 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 144 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 144 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 144 34x51 S9 C 147 N.S9.01
Hydrophobic ICL2 F 144 34x51 S5 F 69 N.S5.10
Van-der-waals ICL2 F 144 34x51 S5 F 69 N.S5.10
Polar TM6 Q 239 6x25 s15s16 L 253 C.s15s16.02
Van-der-waals TM6 Q 239 6x25 s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 F 144 34x51 S15 V 251 C.S15.14
Ionic TM4 R 152 4x39 s5s6 E 74 N.s5s6.03
Polar TM4 R 152 4x39 s5s6 E 74 N.s5s6.03
Van-der-waals TM4 R 152 4x39 s5s6 E 74 N.s5s6.03
Polar ICL2 R 147 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 147 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 147 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals H8 L 315 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals ICL2 R 147 34x54 S8 L 136 N.S8.03
Hydrophobic TM6 I 240 6x26 S6 F 83 N.S6.01
Van-der-waals TM6 I 240 6x26 S6 F 83 N.S6.01
Polar ICL2 R 147 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic ICL2 R 147 34x54 s8s9 S 146 N.s8s9.10
Van-der-waals ICL2 R 147 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic TM6 V 247 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 247 6x33 s5s6 I 79 N.s5s6.08
Polar H8 S 317 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 317 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 317 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 N 243 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 140 3x54 S6 F 83 N.S6.01
Ionic ICL2 R 150 34x57 s5s6 D 75 N.s5s6.04
Polar ICL2 R 150 34x57 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 R 150 34x57 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 R 150 34x57 s5s6 D 75 N.s5s6.04
Polar H8 E 316 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 F 144 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 144 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 144 34x51 S16 Y 259 C.S16.03
Polar TM6 Q 239 6x25 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 Q 239 6x25 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 Q 239 6x25 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 144 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 144 34x51 S16 D 257 C.S16.01
Van-der-waals TM6 M 250 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 F 144 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 F 144 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL1 M 70 12x50 s20c E 395 C.s20c.14
Van-der-waals ICL1 M 70 12x50 s20c E 395 C.s20c.14
Hydrophobic TM6 T 242 6x28 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 242 6x28 s5s6 L 81 N.s5s6.10
Van-der-waals TM7 T 314 7x56 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 A 139 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 A 139 3x53 s5s6 I 79 N.s5s6.08
Polar ICL2 R 147 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 147 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 147 34x54 S5 Y 71 N.S5.12
Hydrophobic TM2 S 72 2x37 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 72 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 R 147 34x54 S9 C 147 N.S9.01
Van-der-waals ICL2 R 147 34x54 S9 C 147 N.S9.01
Hydrophobic TM6 M 250 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 R 145 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 145 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 145 34x52 S16 D 257 C.S16.01
Hydrophobic TM5 L 231 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 143 34x50 S6 F 83 N.S6.01
Ionic TM2 E 73 2x38 s8s9 K 145 N.s8s9.09
Polar TM2 E 73 2x38 s8s9 K 145 N.s8s9.09
Hydrophobic TM2 E 73 2x38 s8s9 K 145 N.s8s9.09
Van-der-waals TM2 E 73 2x38 s8s9 K 145 N.s8s9.09
Ionic ICL1 K 69 12x49 s20c E 394 C.s20c.13
Polar ICL1 K 69 12x49 s20c E 394 C.s20c.13
Van-der-waals ICL1 K 69 12x49 s20c E 394 C.s20c.13