Beta-arrestin-1 - LPA5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA5 75.9
Beta-arrestin-1 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 127 34x51 S8 L 129 N.S8.03
Ionic TM6 R 228 6x29 s20c E 407 C.s20c.17
Polar TM6 R 228 6x29 s20c E 407 C.s20c.17
Van-der-waals TM6 R 228 6x29 s20c E 407 C.s20c.17
Van-der-waals TM6 R 228 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 R 119 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 122 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 122 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 I 123 3x54 S6 F 75 N.S6.01
Hydrophobic TM2 V 57 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 R 130 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic TM3 I 123 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 123 3x54 s5s6 L 73 N.s5s6.10
Polar TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Ionic TM6 R 228 6x29 s5s6 D 69 N.s5s6.06
Ionic ICL2 R 130 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 R 130 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 130 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 130 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 P 126 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 126 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 R 130 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 130 34x54 s8s9 P 131 N.s8s9.02
Polar TM6 T 232 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 I 123 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 R 133 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 133 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 133 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 123 3x54 s5s6 L 68 N.s5s6.05
Ionic ICL2 R 133 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 133 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 133 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 133 34x57 s5s6 D 67 N.s5s6.04
Polar TM6 T 232 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 232 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 232 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 235 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 127 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 127 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 127 34x51 S9 C 140 N.S9.01
Hydrophobic TM6 T 232 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 T 232 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 127 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 127 34x51 S15 I 241 C.S15.14
Hydrophobic TM2 S 55 2x37 s5s6 D 67 N.s5s6.04
Ionic TM4 R 136 4x40 s8s9 E 134 N.s8s9.05
Polar TM4 R 136 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 136 4x40 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 136 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 L 236 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 R 134 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 R 134 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic H8 A 301 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 V 57 2x39 s5s6 D 67 N.s5s6.04
Polar ICL2 R 130 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 130 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 130 34x54 s5s6 R 65 N.s5s6.02
Polar ICL3 T 224 - S6 R 76 N.S6.02
Polar ICL2 L 127 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 127 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 126 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 R 229 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 M 61 2x43 s5s6 V 70 N.s5s6.07
Ionic TM4 R 134 4x38 s8s9 E 134 N.s8s9.05
Polar TM4 R 134 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 218 5x65 s5s6 L 73 N.s5s6.10
Polar ICL2 L 127 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 127 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 127 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 L 218 5x65 S6 F 75 N.S6.01
Hydrophobic ICL2 L 127 34x51 S16 A 247 C.S16.01