Beta-arrestin-2 - LH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LH 80.2
Beta-arrestin-2 76.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 H 473 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 H 473 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 H 473 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL3 L 558 - S6 I 82 N.S6.07
Van-der-waals ICL3 L 558 - S6 I 82 N.S6.07
Hydrophobic TM6 L 574 6x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 L 574 6x40 s5s6 V 71 N.s5s6.07
Polar H8 R 632 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 R 632 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 R 632 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 T 627 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 T 627 8x47 s5s6 D 70 N.s5s6.06
Polar ICL2 H 473 - S16 Y 250 C.S16.03
Hydrophobic ICL2 H 473 - S16 Y 250 C.S16.03
Van-der-waals ICL2 H 473 - S16 Y 250 C.S16.03
Polar C-term K 654 - s20c Y 404 C.s20c.14
Ionic ICL1 K 390 - s8s9 E 135 N.s8s9.05
Polar ICL1 K 390 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 K 390 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 390 - s8s9 E 135 N.s8s9.05
Hydrophobic TM7 F 626 7x56 s5s6 L 72 N.s5s6.08
Polar TM7 F 626 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 K 477 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 477 - s5s6 R 66 N.s5s6.02
Polar ICL2 L 474 - S16 Y 250 C.S16.03
Hydrophobic ICL2 L 474 - S16 Y 250 C.S16.03
Van-der-waals ICL2 L 474 - S16 Y 250 C.S16.03
Hydrophobic TM5 V 553 5x65 S6 R 77 N.S6.02
Hydrophobic TM6 M 571 6x37 S6 F 76 N.S6.01
Van-der-waals TM6 M 571 6x37 S6 F 76 N.S6.01
Polar ICL3 N 555 - S6 D 79 N.S6.04
Van-der-waals ICL3 N 555 - S6 D 79 N.S6.04
Hydrophobic ICL2 I 472 - S5 F 62 N.S5.10
Van-der-waals ICL2 I 472 - S5 F 62 N.S5.10
Hydrophobic ICL2 I 472 - S16 A 248 C.S16.01
Hydrophobic H8 T 629 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 Y 470 3x56 s15s16 S 246 C.s15s16.04
Ionic ICL2 K 477 - s8s9 D 136 N.s8s9.06
Polar ICL2 K 477 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 477 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 I 472 - S8 L 130 N.S8.03
Hydrophobic C-term Y 651 - s20c Y 404 C.s20c.14
Hydrophobic TM3 T 467 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 467 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 A 471 - S9 C 141 N.S9.01
Hydrophobic ICL2 A 471 - S9 C 141 N.S9.01
Van-der-waals ICL2 A 471 - S9 C 141 N.S9.01
Hydrophobic TM3 T 467 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 T 467 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 474 - S9 C 141 N.S9.01
Polar TM3 T 469 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 468 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 468 3x54 S6 F 76 N.S6.01
Hydrophobic ICL3 N 555 - S6 K 78 N.S6.03
Van-der-waals ICL3 N 555 - S6 K 78 N.S6.03
Hydrophobic TM6 I 567 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 567 6x33 s5s6 L 74 N.s5s6.10
Ionic TM3 E 463 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 E 463 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 471 - S5 Y 64 N.S5.12
Van-der-waals ICL2 A 471 - S5 Y 64 N.S5.12
Hydrophobic TM6 I 573 6x39 s5s6 L 72 N.s5s6.08
Polar ICL2 D 475 - S16 Y 250 C.S16.03
Hydrophobic ICL2 D 475 - S16 Y 250 C.S16.03
Van-der-waals ICL2 D 475 - S16 Y 250 C.S16.03
Hydrophobic TM6 L 574 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 574 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 552 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 552 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 468 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 I 468 3x54 S5 Y 64 N.S5.12
Polar TM2 T 392 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 V 553 5x65 S5 Y 64 N.S5.12
Polar TM5 A 552 5x64 S5 Y 64 N.S5.12
Van-der-waals TM5 A 552 5x64 S5 Y 64 N.S5.12
Polar TM7 L 622 7x52 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 L 622 7x52 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 L 622 7x52 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 Y 623 7x53 s5s6 V 71 N.s5s6.07
Polar ICL2 H 473 - S16 A 248 C.S16.01
Hydrophobic ICL2 H 473 - S16 A 248 C.S16.01
Van-der-waals ICL2 H 473 - S16 A 248 C.S16.01
Polar TM6 K 570 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 K 570 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 570 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 549 5x61 S6 F 76 N.S6.01
Van-der-waals TM5 I 549 5x61 S6 F 76 N.S6.01
Hydrophobic TM3 I 468 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 V 553 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 V 553 5x65 S6 F 76 N.S6.01
Hydrophobic TM6 K 570 6x36 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 570 6x36 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 I 472 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 I 472 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 L 474 - S8 L 130 N.S8.03
Hydrophobic TM6 K 563 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 K 563 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 M 571 6x37 s5s6 L 74 N.s5s6.10
Polar TM6 K 570 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 P 394 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 394 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 H 473 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 H 473 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 H 473 - s15s16 S 246 C.s15s16.04
Ionic TM6 K 563 6x29 S6 D 79 N.S6.04
Polar TM6 K 563 6x29 S6 D 79 N.S6.04
Van-der-waals TM6 K 563 6x29 S6 D 79 N.S6.04
Hydrophobic ICL2 I 472 - S15 I 242 C.S15.14
Van-der-waals ICL2 I 472 - S15 I 242 C.S15.14
Hydrophobic TM6 A 560 6x26 S6 D 79 N.S6.04
Polar ICL2 I 472 - S16 Y 250 C.S16.03
Hydrophobic ICL2 I 472 - S16 Y 250 C.S16.03
Van-der-waals ICL2 I 472 - S16 Y 250 C.S16.03
Hydrophobic TM6 A 560 6x26 S6 I 82 N.S6.07
Hydrophobic TM3 R 464 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 464 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 464 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 558 - S6 F 81 N.S6.06
Van-der-waals ICL3 L 558 - S6 F 81 N.S6.06
Hydrophobic ICL3 L 558 - S6 L 80 N.S6.05
Van-der-waals ICL3 L 558 - S6 L 80 N.S6.05
Polar TM6 N 562 6x28 s9s10 E 156 N.s9s10.07