Beta-arrestin-2 - BLT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
BLT1 76.9
Beta-arrestin-2 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Aromatic ICL2 F 123 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 123 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 123 34x51 S5 Y 64 N.S5.12
Ionic ICL3 R 214 - S6 D 79 N.S6.04
Polar ICL3 R 214 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 214 - S6 D 79 N.S6.04
Ionic ICL2 R 129 34x57 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 L 222 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 L 222 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 223 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 118 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 118 3x53 s5s6 R 66 N.s5s6.02
Aromatic ICL2 K 127 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 K 127 34x55 S16 Y 250 C.S16.03
Hydrophobic TM3 V 119 3x54 s5s6 L 69 N.s5s6.05
Polar TM6 T 219 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 219 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 219 6x33 s5s6 L 72 N.s5s6.08
Aromatic ICL3 F 213 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 F 213 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 F 213 - s15s16 F 245 C.s15s16.03
Hydrophobic TM7 G 291 7x59 s5s6 E 67 N.s5s6.03
Van-der-waals TM7 G 291 7x59 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 115 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 F 123 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 123 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 Q 126 34x54 S5 Y 64 N.S5.12
Hydrophobic TM5 L 208 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 208 5x65 S6 F 76 N.S6.01
Hydrophobic TM3 A 118 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 F 213 - S6 R 77 N.S6.02
Van-der-waals ICL3 F 213 - S6 R 77 N.S6.02
Hydrophobic ICL2 P 122 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 122 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM4 T 130 4x38 s17s18 R 286 C.s17s18.11
Polar TM3 A 118 3x53 S5 Y 64 N.S5.12
Hydrophobic TM5 L 208 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 208 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 F 123 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 123 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 123 34x51 S16 Y 250 C.S16.03
Hydrophobic TM4 T 130 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 130 4x38 s8s9 E 135 N.s8s9.05
Polar TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 V 119 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 115 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 115 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 204 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 G 289 7x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 G 289 7x57 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 119 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 119 3x54 S6 F 76 N.S6.01
Polar TM6 T 219 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 T 219 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 T 219 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 F 123 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 123 34x51 S15 I 242 C.S15.14
Polar TM3 R 115 3x50 s5s6 D 68 N.s5s6.04
Polar TM4 K 131 4x39 s8s9 P 134 N.s8s9.04
Polar ICL2 S 125 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 125 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 123 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 F 123 34x51 S9 C 141 N.S9.01
Van-der-waals TM2 V 52 2x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 I 226 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 129 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 129 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 Y 201 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 R 211 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 211 5x68 S6 F 76 N.S6.01
Aromatic ICL3 F 213 - S6 F 76 N.S6.01
Hydrophobic ICL3 F 213 - S6 F 76 N.S6.01
Van-der-waals ICL3 F 213 - S6 F 76 N.S6.01
Hydrophobic TM7 A 288 7x56 s5s6 V 71 N.s5s6.07
Ionic ICL2 R 129 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 129 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 129 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 129 34x57 s5s6 D 68 N.s5s6.04
Ionic TM3 D 114 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 114 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 D 114 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 D 114 3x49 s5s6 R 66 N.s5s6.02
Polar TM7 L 292 7x60 s5s6 E 67 N.s5s6.03
Polar ICL2 R 129 34x57 s17s18 R 286 C.s17s18.11
Polar ICL1 Q 48 12x49 s20c K 400 C.s20c.10
Hydrophobic ICL1 Q 48 12x49 s20c K 400 C.s20c.10
Van-der-waals ICL1 Q 48 12x49 s20c K 400 C.s20c.10
Polar TM7 S 295 7x63 s5s6 E 67 N.s5s6.03
Polar ICL2 P 122 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 122 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 122 34x50 S5 Y 64 N.S5.12
Polar ICL2 K 127 34x55 S16 Q 249 C.S16.02
Hydrophobic TM6 L 222 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 219 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 219 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 126 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 126 34x54 S16 Y 250 C.S16.03
Polar TM4 K 131 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 131 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 131 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 F 123 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 123 34x51 S16 A 248 C.S16.01
Polar TM2 T 53 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 53 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 53 2x39 s5s6 D 68 N.s5s6.04