Arrestin-C - MAS1L complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
MAS1L 60.4
Arrestin-C 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 175 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 V 175 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 V 262 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 262 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 N 106 2x37 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 N 106 2x37 s8s9 K 135 N.s8s9.09
Polar ICL2 C 183 34x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 C 183 34x55 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 C 183 34x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 I 179 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 I 179 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 R 261 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 261 6x32 s5s6 G 68 N.s5s6.09
Polar H8 G 318 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 G 318 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 318 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 Y 108 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic H8 G 318 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 G 318 8x47 s5s6 E 65 N.s5s6.06
Polar ICL2 R 182 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 R 182 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 182 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic H8 G 318 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic C-term P 341 - s17s18 R 282 C.s17s18.11
Van-der-waals C-term P 341 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL3 K 258 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 K 258 - s5s6 T 70 N.s5s6.11
Polar ICL2 C 183 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 C 183 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 C 183 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic TM2 Y 108 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 Y 108 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 R 182 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 182 34x54 s5s6 R 61 N.s5s6.02
Polar TM2 N 106 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 N 106 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 106 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 M 109 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 M 109 2x40 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 178 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 178 34x50 S6 F 71 N.S6.01
Hydrophobic TM3 C 174 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 C 174 3x53 S6 F 71 N.S6.01
Polar ICL2 I 179 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 I 179 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 I 179 34x51 s15s16 Y 241 C.s15s16.03
Polar ICL2 C 183 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 C 183 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 C 183 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 P 178 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 178 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL2 R 182 34x54 S5 Y 59 N.S5.12
Aromatic ICL2 R 182 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL2 R 182 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 R 182 34x54 S5 Y 59 N.S5.12
Polar ICL2 C 183 34x55 S5 Y 59 N.S5.12
Van-der-waals ICL2 C 183 34x55 S5 Y 59 N.S5.12
Polar ICL3 Q 256 - S6 D 74 N.S6.04
Van-der-waals ICL3 Q 256 - S6 D 74 N.S6.04
Ionic H8 R 324 8x53 s20c E 383 C.s20c.17
Polar H8 R 324 8x53 s20c E 383 C.s20c.17
Hydrophobic H8 R 324 8x53 s20c E 383 C.s20c.17
Van-der-waals H8 R 324 8x53 s20c E 383 C.s20c.17
Hydrophobic ICL2 H 184 34x56 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 H 184 34x56 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 C 174 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 C 174 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 R 182 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic TM2 Y 108 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 Y 108 2x39 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 182 34x54 S16 D 244 C.S16.01
Polar ICL2 R 182 34x54 S16 D 244 C.S16.01
Polar ICL2 C 183 34x55 s15s16 Y 241 C.s15s16.03
Polar ICL3 Q 256 - S6 R 72 N.S6.02
Hydrophobic ICL3 Q 256 - S6 R 72 N.S6.02
Van-der-waals ICL3 Q 256 - S6 R 72 N.S6.02
Polar ICL3 Q 257 - s9s10 V 155 N.s9s10.10
Hydrophobic TM6 V 262 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 V 262 6x33 s5s6 G 68 N.s5s6.09
Polar H8 R 321 8x50 s5s6 T 70 N.s5s6.11
Hydrophobic H8 R 321 8x50 s5s6 T 70 N.s5s6.11
Van-der-waals H8 R 321 8x50 s5s6 T 70 N.s5s6.11
Polar ICL2 R 182 34x54 S16 Y 246 C.S16.03
Van-der-waals ICL2 R 182 34x54 S16 Y 246 C.S16.03
Hydrophobic TM3 R 171 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 171 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic C-term P 341 - s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 I 179 34x51 s15s16 L 240 C.s15s16.02
Hydrophobic TM3 V 175 3x54 S6 F 71 N.S6.01
Hydrophobic TM6 V 262 6x33 s5s6 I 67 N.s5s6.08