Beta-arrestin-1 - MAS1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MAS1 69.6
Beta-arrestin-1 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 K 288 8x51 s9s10 K 160 N.s9s10.12
Van-der-waals H8 K 288 8x51 s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 C 142 34x55 S16 A 247 C.S16.01
Van-der-waals ICL2 C 142 34x55 S16 A 247 C.S16.01
Polar ICL3 H 222 - s5s6 T 74 N.s5s6.11
Hydrophobic C-term A 302 - s5s6 V 70 N.s5s6.07
Van-der-waals C-term A 302 - s5s6 V 70 N.s5s6.07
Hydrophobic TM3 S 133 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL3 H 222 - S6 F 75 N.S6.01
Polar ICL2 I 138 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 I 138 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 138 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 214 5x63 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 V 283 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 V 283 7x56 s5s6 L 71 N.s5s6.08
Ionic C-term D 305 - s5s6 R 65 N.s5s6.02
Polar C-term D 305 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term D 305 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term D 305 - s5s6 R 65 N.s5s6.02
Polar ICL2 W 139 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 W 139 34x52 s15s16 N 245 C.s15s16.04
Polar ICL2 C 142 34x55 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 C 142 34x55 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 C 142 34x55 s8s9 G 137 N.s8s9.08
Hydrophobic C-term D 305 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 I 138 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 138 34x51 S15 I 241 C.S15.14
Polar C-term E 306 - s5s6 E 66 N.s5s6.03
Hydrophobic TM5 N 217 5x66 s15s16 F 244 C.s15s16.03
Hydrophobic TM7 V 283 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 V 283 7x56 s5s6 V 70 N.s5s6.07
Ionic H8 K 289 8x52 s20c E 407 C.s20c.17
Polar H8 K 289 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 289 8x52 s20c E 407 C.s20c.17
Hydrophobic ICL2 R 141 34x54 s8s9 G 137 N.s8s9.08
Ionic C-term R 301 - s20c E 407 C.s20c.17
Hydrophobic ICL2 P 137 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 137 34x50 s15s16 F 244 C.s15s16.03
Polar TM3 Y 136 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Y 136 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Y 136 3x56 s15s16 N 245 C.s15s16.04
Polar ICL2 R 141 34x54 S5 Y 63 N.S5.12
Aromatic ICL2 R 141 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 R 141 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 R 141 34x54 S5 Y 63 N.S5.12
Hydrophobic C-term F 303 - s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 R 141 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 141 34x54 s8s9 K 138 N.s8s9.09
Ionic H8 K 288 8x51 s20c D 408 C.s20c.18
Polar H8 K 288 8x51 s20c D 408 C.s20c.18
Ionic C-term E 306 - s5s6 R 65 N.s5s6.02
Polar C-term E 306 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term E 306 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term E 306 - s5s6 R 65 N.s5s6.02
Ionic C-term K 304 - s20c E 404 C.s20c.14
Polar C-term K 304 - s20c E 404 C.s20c.14
Van-der-waals C-term K 304 - s20c E 404 C.s20c.14
Polar C-term E 306 - s5s6 D 67 N.s5s6.04
Hydrophobic C-term E 306 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term E 306 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 141 34x54 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 R 141 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 L 226 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic C-term Q 308 - s8s9 P 133 N.s8s9.04
Van-der-waals C-term Q 308 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 I 138 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 I 138 34x51 s15s16 T 246 C.s15s16.05
Polar ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Polar ICL2 C 142 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 C 142 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 C 142 34x55 S16 Y 249 C.S16.03
Polar ICL2 I 138 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 138 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 I 138 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL3 A 220 - S6 R 76 N.S6.02
Van-der-waals ICL3 A 220 - S6 R 76 N.S6.02
Hydrophobic ICL2 I 138 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 138 34x51 S16 A 247 C.S16.01
Polar ICL2 C 142 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 C 142 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 C 142 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 130 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 130 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 F 66 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 66 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 V 134 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 134 3x54 s5s6 L 73 N.s5s6.10
Polar C-term R 301 - s5s6 V 70 N.s5s6.07
Hydrophobic TM3 V 134 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 134 3x54 S6 F 75 N.S6.01
Polar ICL2 P 137 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 137 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 137 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 137 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 L 226 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 226 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 H 143 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic C-term K 304 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term K 304 - s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 210 5x59 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 226 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 226 6x33 s5s6 L 71 N.s5s6.08