Arrestin-C - MC3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC3 74.4
Arrestin-C 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 142 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 142 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 V 230 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 V 230 - s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 239 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 T 145 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 T 145 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 150 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 150 34x51 S9 C 137 N.S9.01
Polar TM6 S 236 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 S 236 6x29 s5s6 G 68 N.s5s6.09
Hydrophobic TM5 F 213 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 F 213 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 M 210 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 M 210 5x61 s5s6 I 67 N.s5s6.08
Ionic TM5 R 220 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 R 220 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 220 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 220 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 I 221 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 I 221 5x72 S6 K 73 N.S6.03
Polar TM6 S 236 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 S 236 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 A 227 - S6 Y 76 N.S6.06
Van-der-waals ICL3 A 227 - S6 Y 76 N.S6.06
Hydrophobic TM3 R 142 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 L 224 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 L 224 - s17s18 L 311 C.s17s18.40
Hydrophobic TM5 F 213 5x64 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 150 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 150 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 G 240 6x33 s5s6 G 68 N.s5s6.09
Polar TM5 H 217 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 217 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 217 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 217 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term L 322 - s20c E 386 C.s20c.20
Van-der-waals C-term L 322 - s20c E 386 C.s20c.20
Polar ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 A 214 5x65 s5s6 L 69 N.s5s6.10
Polar TM6 G 240 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 G 240 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 G 240 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 P 232 - S6 V 77 N.S6.07
Polar TM3 Y 148 3x56 S16 Y 246 C.S16.03
Hydrophobic TM5 I 221 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 I 221 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 P 232 - S6 D 74 N.S6.04
Van-der-waals ICL3 P 232 - S6 D 74 N.S6.04
Polar ICL3 G 229 - S6 V 77 N.S6.07
Hydrophobic TM3 R 142 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 146 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 146 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 K 239 6x32 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 I 244 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 I 244 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 146 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 146 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 Y 148 3x56 S16 D 244 C.S16.01
Hydrophobic TM2 M 73 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 M 73 2x39 s5s6 V 66 N.s5s6.07
Polar TM3 I 146 3x54 S5 Y 59 N.S5.12
Polar ICL2 L 150 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 150 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 150 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL3 A 227 - S6 V 77 N.S6.07
Ionic ICL2 R 151 34x52 S16 D 244 C.S16.01
Polar ICL2 R 151 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 151 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 151 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 L 150 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 150 34x51 S8 L 126 N.S8.03
Polar ICL2 R 151 34x52 S16 Y 246 C.S16.03
Aromatic ICL2 R 151 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 R 151 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 R 151 34x52 S16 Y 246 C.S16.03
Polar TM5 R 220 5x71 S6 K 73 N.S6.03
Hydrophobic TM5 R 220 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 R 220 5x71 S6 K 73 N.S6.03
Polar ICL2 L 150 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 150 34x51 S5 Y 59 N.S5.12
Hydrophobic TM5 Y 207 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 F 147 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 F 147 3x55 s15s16 S 242 C.s15s16.04
Polar C-term G 323 - s20c E 386 C.s20c.20
Van-der-waals C-term G 323 - s20c E 386 C.s20c.20
Ionic ICL2 H 153 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 H 153 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 H 153 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 H 153 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL3 L 224 - S6 L 75 N.S6.05
Polar TM5 H 217 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 H 217 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 H 217 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic ICL3 L 224 - S6 K 73 N.S6.03
Van-der-waals ICL3 L 224 - S6 K 73 N.S6.03
Polar ICL2 A 149 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 149 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 149 34x50 S5 Y 59 N.S5.12
Hydrophobic TM6 T 243 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 243 6x36 s5s6 I 67 N.s5s6.08