S-arrestin - MC3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC3 73.9
S-arrestin 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 Y 152 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 152 34x53 s8s9 K 145 N.s8s9.09
Polar ICL3 Q 233 - s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 Q 233 - s9s10 E 164 N.s9s10.06
Van-der-waals ICL3 Q 233 - s9s10 E 164 N.s9s10.06
Hydrophobic TM3 R 142 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 142 3x50 s5s6 I 76 N.s5s6.05
Ionic ICL2 H 153 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 H 153 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 H 153 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 H 153 34x54 s8s9 D 142 N.s8s9.06
Polar TM6 S 236 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 S 236 6x29 s5s6 G 80 N.s5s6.09
Ionic ICL2 R 151 34x52 S16 D 257 C.S16.01
Polar ICL2 R 151 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 151 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 151 34x52 S16 D 257 C.S16.01
Hydrophobic ICL3 L 224 - S6 R 85 N.S6.03
Van-der-waals ICL3 L 224 - S6 R 85 N.S6.03
Ionic TM6 K 239 6x32 s9s10 D 166 N.s9s10.08
Polar TM6 K 239 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 T 243 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 T 243 6x36 s5s6 V 78 N.s5s6.07
Polar ICL2 A 149 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 149 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 149 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL3 P 232 - S6 F 89 N.S6.07
Hydrophobic TM3 I 146 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 L 224 - S6 L 87 N.S6.05
Van-der-waals ICL3 L 224 - S6 L 87 N.S6.05
Hydrophobic TM6 G 240 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 G 240 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 Y 74 2x40 s5s6 V 78 N.s5s6.07
Polar H8 L 304 8x48 s5s6 D 77 N.s5s6.06
Polar C-term L 322 - s20c K 397 C.s20c.16
Van-der-waals C-term L 322 - s20c K 397 C.s20c.16
Hydrophobic ICL2 L 150 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 150 34x51 S8 L 136 N.S8.03
Polar ICL2 R 151 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 151 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 151 34x52 S16 Y 259 C.S16.03
Hydrophobic TM6 K 239 6x32 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 239 6x32 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 I 221 5x72 S6 D 86 N.S6.04
Hydrophobic TM6 H 235 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 Q 233 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 Q 233 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL2 L 150 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 150 34x51 S9 C 147 N.S9.01
Polar TM5 R 220 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 R 220 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 R 220 5x71 S6 R 85 N.S6.03
Polar TM6 G 240 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 G 240 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 C 237 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 C 237 6x30 s5s6 L 81 N.s5s6.10
Polar ICL2 L 150 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 150 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 150 34x51 S5 Y 71 N.S5.12
Polar TM6 T 243 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 243 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 243 6x36 s5s6 I 79 N.s5s6.08
Polar TM6 G 240 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 G 240 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 G 240 6x33 s5s6 I 79 N.s5s6.08
Polar ICL2 H 153 34x54 s8s9 K 145 N.s8s9.09
Aromatic ICL2 H 153 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 153 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 153 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 V 230 - S6 F 89 N.S6.07
Van-der-waals ICL3 V 230 - S6 F 89 N.S6.07
Polar TM6 T 243 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 P 232 - S6 D 86 N.S6.04
Hydrophobic ICL2 L 150 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 150 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 L 150 34x51 S16 D 257 C.S16.01
Polar ICL2 L 150 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 150 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 150 34x51 S16 Y 259 C.S16.03
Hydrophobic TM5 F 213 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 F 213 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 146 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 146 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 L 224 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 K 239 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 239 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 I 221 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 I 221 5x72 S6 R 85 N.S6.03
Polar TM5 H 217 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 H 217 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 217 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 217 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 L 224 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 L 224 - s17s18 V 324 C.s17s18.40
Hydrophobic TM7 R 302 7x56 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 R 302 7x56 s5s6 D 77 N.s5s6.06
Polar ICL3 P 225 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL3 P 225 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 P 225 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 I 244 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 F 147 3x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 F 147 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 M 210 5x61 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 M 210 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 A 214 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 T 145 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 T 145 3x53 s5s6 I 76 N.s5s6.05
Polar TM5 H 217 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 H 217 5x68 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 H 217 5x68 s15s16 L 253 C.s15s16.02
Polar TM6 S 236 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 S 236 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 V 230 - s9s10 A 163 N.s9s10.05
Ionic H8 E 305 8x49 s20c R 398 C.s20c.17
Hydrophobic ICL3 A 227 - S6 Y 88 N.S6.06
Van-der-waals ICL3 A 227 - S6 Y 88 N.S6.06
Polar TM7 R 302 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 R 302 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 Y 299 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 299 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic H8 S 303 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 M 73 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 M 73 2x39 s5s6 V 78 N.s5s6.07
Polar C-term G 323 - s20c K 397 C.s20c.16
Hydrophobic C-term G 323 - s20c K 397 C.s20c.16
Van-der-waals C-term G 323 - s20c K 397 C.s20c.16