Arrestin-C - MC4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC4 75.2
Arrestin-C 80.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 H 222 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 222 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 222 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 222 5x68 s15s16 Y 241 C.s15s16.03
Polar TM5 H 222 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 H 222 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 H 222 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM6 K 242 6x32 s5s6 G 68 N.s5s6.09
Polar TM3 F 152 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 F 152 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 F 152 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 155 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 155 34x51 S15 V 238 C.S15.14
Polar TM3 Y 153 3x56 S5 Y 59 N.S5.12
Polar TM5 H 222 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 H 222 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 H 222 5x68 S6 K 73 N.S6.03
Polar TM6 T 246 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 246 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 246 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 229 5x75 S6 L 75 N.S6.05
Van-der-waals TM5 L 229 5x75 S6 L 75 N.S6.05
Hydrophobic ICL3 I 235 - S6 V 77 N.S6.07
Van-der-waals ICL3 I 235 - S6 V 77 N.S6.07
Hydrophobic TM6 L 247 6x37 s5s6 I 67 N.s5s6.08
Polar TM6 G 243 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 G 243 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 G 243 6x33 s5s6 I 67 N.s5s6.08
Polar TM6 Q 237 6x27 S6 D 74 N.S6.04
Van-der-waals TM6 Q 237 6x27 S6 D 74 N.S6.04
Ionic H8 K 311 8x52 s20c E 383 C.s20c.17
Polar H8 K 311 8x52 s20c E 383 C.s20c.17
Van-der-waals H8 K 311 8x52 s20c E 383 C.s20c.17
Hydrophobic ICL3 G 231 - S6 Y 76 N.S6.06
Van-der-waals ICL3 G 231 - S6 Y 76 N.S6.06
Hydrophobic TM5 I 223 5x69 S6 K 73 N.S6.03
Polar TM6 N 240 6x30 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 155 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 155 34x51 S16 Y 246 C.S16.03
Hydrophobic TM5 M 215 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 M 215 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 226 5x72 S6 D 74 N.S6.04
Van-der-waals TM5 I 226 5x72 S6 D 74 N.S6.04
Hydrophobic TM3 F 152 3x55 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 F 152 3x55 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 G 243 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 155 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 155 34x51 S8 L 126 N.S8.03
Polar ICL2 A 154 34x50 S16 D 244 C.S16.01
Hydrophobic ICL3 T 232 - S6 V 77 N.S6.07
Van-der-waals ICL3 T 232 - S6 V 77 N.S6.07
Hydrophobic ICL3 T 232 - S6 Y 76 N.S6.06
Van-der-waals ICL3 T 232 - S6 Y 76 N.S6.06
Ionic ICL2 H 158 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 H 158 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 H 158 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 H 158 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 Q 156 34x52 S16 K 245 C.S16.02
Van-der-waals ICL2 Q 156 34x52 S16 K 245 C.S16.02
Hydrophobic TM5 R 225 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 R 225 5x71 s17s18 L 311 C.s17s18.40
Polar ICL3 T 232 - S6 L 75 N.S6.05
Hydrophobic ICL3 T 232 - S6 L 75 N.S6.05
Polar ICL2 A 154 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 154 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 154 34x50 S5 Y 59 N.S5.12
Polar TM6 T 246 6x36 s5s6 G 68 N.s5s6.09
Ionic TM5 R 225 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 R 225 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 225 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 225 5x71 s17s18 E 310 C.s17s18.39
Polar ICL2 Q 156 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 Q 156 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 Q 156 34x52 S16 D 244 C.S16.01
Hydrophobic TM5 A 219 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 219 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 M 79 2x39 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 Y 153 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 Y 153 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 L 229 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 L 229 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM3 I 151 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 151 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 T 150 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 T 150 3x53 S5 Y 59 N.S5.12
Polar TM3 I 151 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 I 151 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 I 151 3x54 S5 Y 59 N.S5.12
Polar TM3 R 147 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 147 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 147 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 151 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 Y 212 5x58 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 Y 212 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 226 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 I 226 5x72 S6 K 73 N.S6.03
Polar ICL2 L 155 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 155 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 155 34x51 S16 D 244 C.S16.01
Hydrophobic TM5 I 226 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM2 M 79 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 M 79 2x39 s5s6 V 66 N.s5s6.07
Polar TM3 F 152 3x55 s15s16 L 243 C.s15s16.05
Hydrophobic TM5 I 226 5x72 S6 L 75 N.S6.05
Van-der-waals TM5 I 226 5x72 S6 L 75 N.S6.05
Polar TM6 N 240 6x30 s5s6 T 70 N.s5s6.11
Polar ICL2 H 158 34x54 s17s18 R 282 C.s17s18.11
Aromatic ICL2 H 158 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 H 158 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 H 158 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic TM3 T 150 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 147 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 147 3x50 s5s6 V 66 N.s5s6.07