Beta-arrestin-2 - MC5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC5 77.2
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 H 151 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 H 151 34x54 s17s18 R 286 C.s17s18.11
Polar TM7 R 298 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 R 298 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 R 298 7x56 s5s6 V 71 N.s5s6.07
Ionic ICL3 R 229 - S6 D 79 N.S6.04
Polar ICL3 R 229 - S6 D 79 N.S6.04
Hydrophobic ICL3 R 229 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 229 - S6 D 79 N.S6.04
Hydrophobic ICL3 L 222 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 222 - S6 K 78 N.S6.03
Hydrophobic TM6 V 240 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 240 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 H 151 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 H 151 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 H 151 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 148 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 148 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 L 148 34x51 S9 C 141 N.S9.01
Hydrophobic ICL3 L 222 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL3 L 222 - S6 L 80 N.S6.05
Hydrophobic TM3 T 143 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 143 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 H 151 34x54 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 219 5x72 S6 K 78 N.S6.03
Hydrophobic TM3 I 144 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 144 3x54 s5s6 L 69 N.s5s6.05
Polar TM6 G 236 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 G 236 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 G 236 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 148 34x51 S8 L 130 N.S8.03
Polar TM3 I 144 3x54 S5 Y 64 N.S5.12
Hydrophobic TM2 M 71 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 L 148 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 148 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 148 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 M 208 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 M 208 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Polar TM5 H 215 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 215 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 215 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 215 5x68 s15s16 F 245 C.s15s16.03
Polar TM6 T 239 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 239 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 239 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 R 229 - S6 K 78 N.S6.03
Van-der-waals ICL3 R 229 - S6 K 78 N.S6.03
Hydrophobic TM5 A 212 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 212 5x65 s5s6 L 74 N.s5s6.10
Polar ICL3 R 229 - S6 R 77 N.S6.02
Hydrophobic ICL3 R 229 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 229 - S6 R 77 N.S6.02
Hydrophobic TM5 H 215 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 I 144 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 144 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 R 231 6x28 s9s10 K 158 N.s9s10.09
Polar H8 K 304 8x52 s20c Q 407 C.s20c.17
Hydrophobic TM6 T 239 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 212 5x65 S6 F 76 N.S6.01
Hydrophobic TM3 I 144 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 L 148 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 148 34x51 S5 Y 64 N.S5.12
Polar H8 Q 300 8x48 s5s6 D 70 N.s5s6.06
Ionic ICL2 H 151 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 H 151 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 H 151 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 H 151 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 I 219 5x72 S6 R 77 N.S6.02
Polar TM2 Y 72 2x40 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 148 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 148 34x51 S16 A 248 C.S16.01
Polar H8 E 301 8x49 s20c Y 404 C.s20c.14
Hydrophobic H8 E 301 8x49 s20c Y 404 C.s20c.14
Van-der-waals H8 E 301 8x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 Y 150 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 150 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 I 219 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 219 5x72 s15s16 F 245 C.s15s16.03
Polar ICL2 A 147 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 147 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 147 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 I 144 3x54 s5s6 L 72 N.s5s6.08