Beta-arrestin-2 - MCH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MCH1 67.4
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 224 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 224 34x57 s5s6 R 66 N.s5s6.02
Polar ICL2 I 218 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 218 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 218 34x51 S5 Y 64 N.S5.12
Hydrophobic N-term C 33 - S16 P 253 C.S16.06
Van-der-waals N-term C 33 - S16 P 253 C.S16.06
Polar N-term C 36 - S16 Q 249 C.S16.02
Hydrophobic ICL2 I 218 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 218 34x51 S16 A 248 C.S16.01
Polar TM3 R 210 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 210 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 210 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 T 214 3x54 s5s6 L 74 N.s5s6.10
Polar N-term C 33 - S16 C 252 C.S16.05
Hydrophobic N-term C 33 - S16 C 252 C.S16.05
Van-der-waals N-term C 33 - S16 C 252 C.S16.05
Hydrophobic ICL3 A 311 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 311 - S6 D 79 N.S6.04
Polar TM6 R 319 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 319 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 319 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 T 326 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 T 221 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 T 221 34x54 S16 Y 250 C.S16.03
Polar TM6 R 319 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 319 6x29 s5s6 G 73 N.s5s6.09
Ionic H8 R 390 8x53 s5s6 E 67 N.s5s6.03
Polar H8 R 390 8x53 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 390 8x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 A 213 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 213 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 217 34x50 s15s16 S 246 C.s15s16.04
Polar H8 T 386 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 T 386 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 T 386 8x49 s5s6 D 70 N.s5s6.06
Polar TM2 V 146 2x38 s5s6 D 68 N.s5s6.04
Polar N-term C 33 - S16 K 251 C.S16.04
Hydrophobic N-term C 33 - S16 K 251 C.S16.04
Van-der-waals N-term C 33 - S16 K 251 C.S16.04
Polar TM2 N 145 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 A 309 - S6 K 78 N.S6.03
Van-der-waals ICL3 A 309 - S6 K 78 N.S6.03
Hydrophobic TM6 V 323 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 323 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic N-term A 35 - S16 Y 250 C.S16.03
Hydrophobic TM3 T 214 3x54 s5s6 L 69 N.s5s6.05
Polar TM6 R 319 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 319 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 319 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 217 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 M 304 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 304 5x65 s5s6 L 74 N.s5s6.10
Polar TM2 N 145 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 N 145 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic N-term A 35 - S16 Q 249 C.S16.02
Van-der-waals N-term A 35 - S16 Q 249 C.S16.02
Hydrophobic ICL3 S 307 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 S 307 - s15s16 F 245 C.s15s16.03
Polar N-term C 36 - S16 K 251 C.S16.04
Hydrophobic N-term C 36 - S16 K 251 C.S16.04
Van-der-waals N-term C 36 - S16 K 251 C.S16.04
Polar ICL2 P 217 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 217 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 217 34x50 S5 Y 64 N.S5.12
Hydrophobic TM6 V 323 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 323 6x33 s5s6 L 74 N.s5s6.10
Aromatic TM6 R 319 6x29 S6 F 76 N.S6.01
Ionic TM1 K 137 1x60 s5s6 E 67 N.s5s6.03
Polar TM1 K 137 1x60 s5s6 E 67 N.s5s6.03
Van-der-waals TM1 K 137 1x60 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 H 216 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 P 147 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 147 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 I 218 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 218 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 S 219 34x52 S16 A 248 C.S16.01
Ionic ICL2 R 224 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 224 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 224 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 224 34x57 s5s6 D 68 N.s5s6.04
Ionic ICL1 H 141 - s20c D 402 C.s20c.12
Hydrophobic ICL1 H 141 - s20c D 402 C.s20c.12
Polar ICL2 T 221 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 221 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 221 34x54 s5s6 R 66 N.s5s6.02
Polar N-term G 34 - S16 K 251 C.S16.04
Hydrophobic N-term L 30 - s17s18 K 285 C.s17s18.10
Hydrophobic ICL3 P 310 - S6 D 79 N.S6.04
Hydrophobic ICL2 P 217 34x50 S6 F 76 N.S6.01
Hydrophobic TM2 P 147 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 147 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 I 218 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 218 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 218 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 Y 297 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 300 5x61 s5s6 L 72 N.s5s6.08
Polar ICL2 S 219 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 S 219 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 T 221 34x54 S5 Y 64 N.S5.12
Van-der-waals ICL2 T 221 34x54 S5 Y 64 N.S5.12
Polar TM5 R 303 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 303 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 303 5x64 s15s16 F 245 C.s15s16.03
Polar H8 C 384 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 C 384 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 C 384 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 210 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 210 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 I 218 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 I 218 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 I 218 34x51 s15s16 L 244 C.s15s16.02
Hydrophobic TM3 T 214 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 T 214 3x54 S6 F 76 N.S6.01