Arrestin-C - MCH2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
MCH2 76.2
Arrestin-C 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 139 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 F 139 34x51 S15 V 238 C.S15.14
Polar ICL3 C 237 - S6 V 77 N.S6.07
Hydrophobic ICL3 C 237 - S6 V 77 N.S6.07
Van-der-waals ICL3 C 237 - S6 V 77 N.S6.07
Hydrophobic ICL2 P 138 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 138 34x50 s15s16 S 242 C.s15s16.04
Polar H8 Q 319 8x56 s20c G 387 C.s20c.21
Hydrophobic H8 Q 319 8x56 s20c G 387 C.s20c.21
Van-der-waals H8 Q 319 8x56 s20c G 387 C.s20c.21
Van-der-waals TM6 N 238 6x22 S5 M 52 N.S5.05
Polar ICL2 F 139 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 F 139 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 F 139 34x51 S16 Y 246 C.S16.03
Hydrophobic TM6 N 238 6x22 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 M 252 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 252 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 T 66 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic C-term E 326 - s20c S 388 C.s20c.22
Van-der-waals C-term E 326 - s20c S 388 C.s20c.22
Aromatic ICL2 F 139 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 139 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 139 34x51 S5 Y 59 N.S5.12
Polar TM5 Q 230 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 Q 230 5x71 S6 K 73 N.S6.03
Hydrophobic TM3 L 135 3x54 s5s6 I 67 N.s5s6.08
Polar ICL3 C 236 - S6 D 74 N.S6.04
Hydrophobic ICL3 C 236 - S6 D 74 N.S6.04
Van-der-waals ICL3 C 236 - S6 D 74 N.S6.04
Hydrophobic TM6 R 245 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 245 6x29 S6 R 72 N.S6.02
Polar ICL2 T 142 34x54 S16 Y 246 C.S16.03
Hydrophobic ICL2 P 138 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 P 68 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 P 68 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 L 249 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 249 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 A 234 - s17s18 L 311 C.s17s18.40
Hydrophobic TM2 P 68 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 P 68 2x39 s5s6 D 63 N.s5s6.04
Polar TM6 R 245 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 245 6x29 s5s6 T 70 N.s5s6.11
Polar ICL2 P 138 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 M 227 5x68 S6 F 71 N.S6.01
Polar ICL2 F 139 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 F 139 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 139 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 T 66 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 66 2x37 s5s6 V 66 N.s5s6.07
Polar ICL2 R 140 34x52 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 R 140 34x52 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 140 34x52 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 L 135 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 L 135 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 L 135 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 L 135 3x54 s5s6 L 69 N.s5s6.10
Polar TM4 R 147 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic ICL3 C 236 - S6 Y 76 N.S6.06
Van-der-waals TM3 V 136 3x55 s15s16 Y 241 C.s15s16.03
Polar H8 N 312 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 312 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 312 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 F 139 34x51 S5 F 57 N.S5.10
Polar TM6 N 238 6x22 s9s10 P 151 N.s9s10.03
Van-der-waals TM6 N 238 6x22 s9s10 P 151 N.s9s10.03
Hydrophobic TM3 L 135 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 135 3x54 s5s6 L 64 N.s5s6.05
Polar H8 S 310 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 S 310 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 S 310 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 I 72 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 I 72 2x43 s5s6 V 66 N.s5s6.07
Polar ICL3 C 236 - S6 L 75 N.S6.05
Hydrophobic ICL3 C 236 - S6 L 75 N.S6.05
Van-der-waals ICL3 C 236 - S6 L 75 N.S6.05
Hydrophobic TM5 Y 223 5x64 S6 F 71 N.S6.01
Ionic C-term R 323 - s20c E 386 C.s20c.20
Polar C-term R 323 - s20c E 386 C.s20c.20
Van-der-waals C-term R 323 - s20c E 386 C.s20c.20
Polar TM5 Y 223 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Y 223 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 Y 223 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL1 K 64 - s8s9 A 133 N.s8s9.07
Polar ICL2 F 139 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 F 139 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 F 139 34x51 S16 D 244 C.S16.01
Ionic ICL2 R 145 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 145 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 145 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 145 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 A 134 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 134 3x53 s5s6 L 64 N.s5s6.05
Polar TM5 N 231 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 N 231 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 N 231 5x72 S6 K 73 N.S6.03
Hydrophobic ICL2 F 139 34x51 S8 L 126 N.S8.03
Hydrophobic ICL2 T 142 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 T 142 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 T 66 2x37 s5s6 D 62 N.s5s6.03
Polar ICL2 P 138 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 138 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 139 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 F 139 34x51 S9 C 137 N.S9.01
Polar H8 S 310 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 Q 137 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 M 227 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 M 227 5x68 s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 140 34x52 S16 D 244 C.S16.01
Polar ICL2 R 140 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 140 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 140 34x52 S16 D 244 C.S16.01
Hydrophobic TM5 M 227 5x68 S6 K 73 N.S6.03
Ionic ICL1 R 63 - s20c E 383 C.s20c.17