Beta-arrestin-1 - MRGPRD complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MRGPRD 74.8
Beta-arrestin-1 78.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term E 307 - s20c K 403 C.s20c.13
Van-der-waals C-term E 307 - s20c K 403 C.s20c.13
Polar ICL2 P 130 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 130 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 130 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL3 W 212 - S6 K 77 N.S6.03
Van-der-waals ICL3 W 212 - S6 K 77 N.S6.03
Polar TM3 F 129 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 F 129 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 F 129 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 201 5x59 s5s6 L 73 N.s5s6.10
Polar TM3 S 126 3x53 s8s9 K 138 N.s8s9.09
Polar ICL2 C 135 34x55 S5 Y 63 N.S5.12
Hydrophobic ICL2 C 135 34x55 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 C 135 34x55 s8s9 G 137 N.s8s9.08
Hydrophobic TM2 I 65 2x43 s5s6 V 70 N.s5s6.07
Polar TM4 R 139 4x39 s8s9 P 133 N.s8s9.04
Polar ICL2 K 134 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 K 134 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 134 34x54 s8s9 T 136 N.s8s9.07
Aromatic TM5 W 204 5x62 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 W 204 5x62 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 W 204 5x62 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 L 219 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 219 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 304 - s20c E 404 C.s20c.14
Hydrophobic C-term P 304 - s20c K 403 C.s20c.13
Van-der-waals C-term P 304 - s20c K 403 C.s20c.13
Polar ICL2 R 137 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 137 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 137 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 127 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 127 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 P 130 34x50 S6 F 75 N.S6.01
Hydrophobic TM6 L 219 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 219 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 306 - s20c D 401 C.s20c.11
Van-der-waals C-term L 306 - s20c D 401 C.s20c.11
Hydrophobic TM7 V 279 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 H 136 34x56 S16 A 247 C.S16.01
Van-der-waals ICL2 H 136 34x56 S16 A 247 C.S16.01
Hydrophobic TM5 W 204 5x62 S6 F 75 N.S6.01
Van-der-waals TM5 W 204 5x62 S6 F 75 N.S6.01
Hydrophobic TM3 S 126 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 S 126 3x53 S6 F 75 N.S6.01
Hydrophobic ICL2 K 134 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 K 134 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 P 130 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 130 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 134 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 K 134 34x54 S5 Y 63 N.S5.12
Polar ICL2 W 132 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 W 132 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 W 132 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 W 212 - S6 D 78 N.S6.04
Van-der-waals ICL3 W 212 - S6 D 78 N.S6.04
Hydrophobic C-term P 304 - s20c E 405 C.s20c.15
Polar ICL2 K 134 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 K 134 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 K 134 34x54 s8s9 G 137 N.s8s9.08
Ionic C-term E 302 - s5s6 R 65 N.s5s6.02
Polar C-term E 302 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term E 302 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term E 302 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 V 127 3x54 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 V 127 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 F 61 2x39 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 F 61 2x39 s5s6 L 68 N.s5s6.05
Hydrophobic C-term E 302 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term E 302 - s5s6 D 67 N.s5s6.04
Ionic H8 R 283 8x50 s20c E 405 C.s20c.15
Polar H8 R 283 8x50 s20c E 405 C.s20c.15
Hydrophobic H8 R 283 8x50 s20c E 405 C.s20c.15
Van-der-waals H8 R 283 8x50 s20c E 405 C.s20c.15
Hydrophobic TM2 F 61 2x39 s5s6 L 71 N.s5s6.08
Polar ICL2 C 135 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 C 135 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 C 135 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 I 131 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 131 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 H 136 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 130 34x50 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 V 127 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 127 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic C-term L 300 - s5s6 V 70 N.s5s6.07
Van-der-waals C-term L 300 - s5s6 V 70 N.s5s6.07
Polar ICL2 C 135 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 C 135 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 C 135 34x55 S16 Y 249 C.S16.03
Hydrophobic C-term E 305 - s20c K 403 C.s20c.13
Van-der-waals C-term E 305 - s20c K 403 C.s20c.13
Hydrophobic ICL2 C 135 34x55 S15 I 241 C.S15.14
Hydrophobic ICL2 K 134 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 134 34x54 s5s6 R 65 N.s5s6.02
Polar ICL2 I 131 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 131 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 I 131 34x51 S5 Y 63 N.S5.12
Ionic H8 R 283 8x50 s20c E 407 C.s20c.17
Hydrophobic ICL2 I 131 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 I 131 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 131 34x51 S16 A 247 C.S16.01
Hydrophobic TM7 V 279 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 V 279 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals ICL2 K 134 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic TM5 V 205 5x63 s5s6 L 73 N.s5s6.10
Hydrophobic C-term L 306 - s20c K 403 C.s20c.13
Van-der-waals C-term L 306 - s20c K 403 C.s20c.13
Hydrophobic TM3 R 123 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 123 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic H8 R 283 8x50 s9s10 K 160 N.s9s10.12
Van-der-waals H8 R 283 8x50 s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 I 131 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 131 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 P 130 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 130 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 W 212 - S6 R 76 N.S6.02
Van-der-waals ICL3 W 212 - S6 R 76 N.S6.02
Polar TM2 N 59 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 59 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM4 R 139 4x39 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 I 131 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 I 131 34x51 s15s16 L 243 C.s15s16.02