ArrestinDb

Arrestin-C - MRGPRD complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
MRGPRD	74.7
Arrestin-C	78.9

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 23.0

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	ICL2	K	134	34x54	s15s16	S	242	C.s15s16.04
Hydrophobic	C-term	P	304	-	s17s18	R	282	C.s17s18.11
Hydrophobic	ICL2	I	131	34x51	s15s16	L	240	C.s15s16.02
Hydrophobic	ICL3	W	212	-	S6	K	73	N.S6.03
Hydrophobic	ICL3	R	214	-	S9	E	142	N.S9.06
Hydrophobic	H8	R	283	8x50	s5s6	E	65	N.s5s6.06
Hydrophobic	H8	R	286	8x53	s20c	E	383	C.s20c.17
Hydrophobic	TM2	F	61	2x39	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	K	134	34x54	S16	D	244	C.S16.01
Hydrophobic	TM5	L	201	5x59	s5s6	L	69	N.s5s6.10
Hydrophobic	H8	G	280	8x47	s5s6	V	66	N.s5s6.07
Hydrophobic	TM6	L	219	6x33	s5s6	G	68	N.s5s6.09
Hydrophobic	H8	R	286	8x53	s20c	A	379	C.s20c.12
Hydrophobic	TM3	R	123	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	V	127	3x54	S6	F	71	N.S6.01
Hydrophobic	ICL2	C	135	34x55	s15s16	L	243	C.s15s16.05
Hydrophobic	TM3	V	127	3x54	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	W	212	-	S6	R	72	N.S6.02
Hydrophobic	ICL3	R	213	-	s9s10	P	151	N.s9s10.03
Hydrophobic	TM3	R	123	3x50	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	R	213	-	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL3	W	212	-	S5	T	54	N.S5.07
Hydrophobic	ICL2	I	131	34x51	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL3	W	212	-	S6	D	74	N.S6.04
Hydrophobic	TM6	L	219	6x33	s5s6	I	67	N.s5s6.08
Hydrophobic	H8	R	286	8x53	s20c	V	380	C.s20c.13
Hydrophobic	TM2	N	59	2x37	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL2	K	134	34x54	s8s9	K	135	N.s8s9.09
Hydrophobic	ICL3	R	213	-	S5	M	52	N.S5.05
Hydrophobic	ICL2	I	131	34x51	s15s16	V	239	C.s15s16.01
Hydrophobic	ICL2	P	130	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	K	134	34x54	S5	Y	59	N.S5.12
Hydrophobic	TM2	F	61	2x39	s5s6	I	67	N.s5s6.08
Hydrophobic	TM6	L	219	6x33	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	P	130	34x50	S6	F	71	N.S6.01
Hydrophobic	ICL2	H	136	34x56	s15s16	L	243	C.s15s16.05
Hydrophobic	TM3	S	126	3x53	S6	F	71	N.S6.01
Hydrophobic	ICL3	W	212	-	S5	A	56	N.S5.09
Hydrophobic	ICL2	C	135	34x55	S16	D	244	C.S16.01
Hydrophobic	ICL2	K	134	34x54	s8s9	G	134	N.s8s9.08
Hydrophobic	ICL2	C	135	34x55	s15s16	S	242	C.s15s16.04
Hydrophobic	TM5	W	204	5x62	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	I	131	34x51	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	I	131	34x51	s15s16	L	243	C.s15s16.05
Ionic	ICL3	R	214	-	S9	E	142	N.S9.06
Ionic	H8	R	283	8x50	s5s6	E	65	N.s5s6.06
Ionic	H8	R	286	8x53	s20c	E	383	C.s20c.17
Ionic	ICL2	K	134	34x54	S16	D	244	C.S16.01
Ionic	H8	R	283	8x50	s5s6	D	62	N.s5s6.03
Ionic	ICL3	R	213	-	s9s10	E	152	N.s9s10.07
Polar	ICL2	K	134	34x54	s15s16	S	242	C.s15s16.04
Polar	ICL3	R	214	-	S9	E	142	N.S9.06
Polar	H8	R	283	8x50	s5s6	E	65	N.s5s6.06
Polar	H8	R	286	8x53	s20c	E	383	C.s20c.17
Polar	ICL2	K	134	34x54	S16	D	244	C.S16.01
Polar	ICL3	R	214	-	S10	Y	160	N.S10.01
Polar	H8	G	280	8x47	s5s6	V	66	N.s5s6.07
Polar	H8	R	286	8x53	s20c	A	379	C.s20c.12
Polar	TM2	N	59	2x37	s8s9	K	135	N.s8s9.09
Polar	ICL2	C	135	34x55	s15s16	L	243	C.s15s16.05
Polar	ICL3	W	212	-	S6	R	72	N.S6.02
Polar	ICL3	R	213	-	s9s10	P	151	N.s9s10.03
Polar	ICL2	I	131	34x51	s15s16	Y	241	C.s15s16.03
Polar	TM2	N	59	2x37	s5s6	D	63	N.s5s6.04
Polar	TM2	N	59	2x37	s5s6	R	61	N.s5s6.02
Polar	ICL2	K	134	34x54	S5	Y	59	N.S5.12
Polar	ICL3	R	213	-	S6	T	79	N.S6.09
Polar	ICL2	K	134	34x54	S16	Y	246	C.S16.03
Polar	C-term	E	302	-	s17s18	R	282	C.s17s18.11
Polar	ICL2	C	135	34x55	S16	D	244	C.S16.01
Polar	ICL2	C	135	34x55	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	K	134	34x54	s15s16	S	242	C.s15s16.04
Van-der-waals	C-term	P	304	-	s17s18	R	282	C.s17s18.11
Van-der-waals	ICL3	W	212	-	S6	K	73	N.S6.03
Van-der-waals	ICL3	R	214	-	S9	E	142	N.S9.06
Van-der-waals	H8	R	283	8x50	s5s6	E	65	N.s5s6.06
Van-der-waals	H8	R	286	8x53	s20c	E	383	C.s20c.17
Van-der-waals	TM2	F	61	2x39	s5s6	L	64	N.s5s6.05
Van-der-waals	ICL2	K	134	34x54	S16	D	244	C.S16.01
Van-der-waals	H8	G	280	8x47	s5s6	V	66	N.s5s6.07
Van-der-waals	TM6	L	219	6x33	s5s6	G	68	N.s5s6.09
Van-der-waals	H8	R	286	8x53	s20c	A	379	C.s20c.12
Van-der-waals	ICL3	R	214	-	S6	R	72	N.S6.02
Van-der-waals	TM3	R	123	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	TM3	V	127	3x54	S6	F	71	N.S6.01
Van-der-waals	ICL2	C	135	34x55	s15s16	L	243	C.s15s16.05
Van-der-waals	TM3	V	127	3x54	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL3	W	212	-	S6	R	72	N.S6.02
Van-der-waals	ICL3	R	213	-	s9s10	P	151	N.s9s10.03
Van-der-waals	ICL3	R	213	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL2	I	131	34x51	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL3	W	212	-	S6	D	74	N.S6.04
Van-der-waals	TM6	L	219	6x33	s5s6	I	67	N.s5s6.08
Van-der-waals	H8	R	286	8x53	s20c	V	380	C.s20c.13
Van-der-waals	TM2	N	59	2x37	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL3	R	213	-	S5	M	52	N.S5.05
Van-der-waals	TM2	N	59	2x37	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL2	I	131	34x51	s15s16	V	239	C.s15s16.01
Van-der-waals	ICL2	P	130	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	K	134	34x54	S5	Y	59	N.S5.12
Van-der-waals	TM2	F	61	2x39	s5s6	I	67	N.s5s6.08
Van-der-waals	TM6	L	219	6x33	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL3	R	213	-	S6	T	79	N.S6.09
Van-der-waals	TM3	S	126	3x53	s5s6	L	69	N.s5s6.10
Van-der-waals	TM3	S	126	3x53	S6	F	71	N.S6.01
Van-der-waals	ICL2	K	134	34x54	S16	Y	246	C.S16.03
Van-der-waals	ICL3	W	212	-	S5	A	56	N.S5.09
Van-der-waals	C-term	E	302	-	s17s18	R	282	C.s17s18.11
Van-der-waals	ICL2	C	135	34x55	S16	D	244	C.S16.01
Van-der-waals	ICL2	K	134	34x54	s8s9	G	134	N.s8s9.08
Van-der-waals	ICL2	C	135	34x55	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	I	131	34x51	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	I	131	34x51	s15s16	L	243	C.s15s16.05

Showing 1 to 113 of 113 entries

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Main reference

Arrestin-C - MRGPRD complex model Download Full