Arrestin-C - MRGPRE complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MRGPRE 72.9
Arrestin-C 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term G 291 - s5s6 D 62 N.s5s6.03
Hydrophobic C-term G 291 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term G 291 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 R 55 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 Y 54 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 Y 54 - s8s9 A 133 N.s8s9.07
Hydrophobic C-term I 310 - S6 Y 76 N.S6.06
Polar TM6 R 213 6x31 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 R 213 6x31 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 R 213 6x31 s9s10 T 154 N.s9s10.09
Polar C-term G 291 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term G 291 - s5s6 D 63 N.s5s6.04
Van-der-waals C-term G 291 - s5s6 D 63 N.s5s6.04
Polar C-term S 303 - S5 T 54 N.S5.07
Hydrophobic C-term S 303 - S5 T 54 N.S5.07
Polar C-term G 291 - s5s6 R 61 N.s5s6.02
Hydrophobic C-term G 291 - s5s6 R 61 N.s5s6.02
Van-der-waals C-term G 291 - s5s6 R 61 N.s5s6.02
Polar H8 Q 276 8x50 s9s10 K 157 N.s9s10.12
Van-der-waals H8 Q 276 8x50 s9s10 K 157 N.s9s10.12
Ionic TM4 R 137 4x39 S16 D 244 C.S16.01
Polar TM4 R 137 4x39 S16 D 244 C.S16.01
Hydrophobic TM4 R 137 4x39 S16 D 244 C.S16.01
Van-der-waals TM4 R 137 4x39 S16 D 244 C.S16.01
Polar C-term E 295 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term E 295 - s5s6 D 62 N.s5s6.03
Polar C-term L 290 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term L 290 - s5s6 D 63 N.s5s6.04
Van-der-waals C-term L 290 - s5s6 D 63 N.s5s6.04
Polar ICL2 C 133 34x55 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 C 133 34x55 s17s18 E 310 C.s17s18.39
Polar C-term G 297 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term G 297 - s9s10 K 157 N.s9s10.12
Hydrophobic TM6 L 218 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 218 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 N 56 2x37 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 N 56 2x37 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 A 124 3x53 s15s16 Y 241 C.s15s16.03
Polar TM2 N 56 2x37 s8s9 K 135 N.s8s9.09
Hydrophobic TM2 N 56 2x37 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 N 56 2x37 s8s9 K 135 N.s8s9.09
Polar TM1 N 52 1x60 s5s6 R 61 N.s5s6.02
Hydrophobic TM1 N 52 1x60 s5s6 R 61 N.s5s6.02
Van-der-waals TM1 N 52 1x60 s5s6 R 61 N.s5s6.02
Polar C-term V 299 - S10 Y 160 N.S10.01
Hydrophobic C-term V 299 - S10 Y 160 N.S10.01
Van-der-waals C-term V 299 - S10 Y 160 N.S10.01
Polar C-term T 302 - S6 R 72 N.S6.02
Hydrophobic C-term T 302 - S6 R 72 N.S6.02
Van-der-waals C-term T 302 - S6 R 72 N.S6.02
Hydrophobic ICL2 S 132 34x54 s15s16 L 240 C.s15s16.02
Hydrophobic TM7 Y 269 7x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 Y 269 7x53 s5s6 I 67 N.s5s6.08
Hydrophobic C-term L 307 - S6 V 77 N.S6.07
Van-der-waals C-term L 307 - S6 V 77 N.S6.07
Hydrophobic C-term A 298 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term A 298 - s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 C 133 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 C 133 34x55 s15s16 L 243 C.s15s16.05
Polar ICL2 S 132 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 S 132 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 S 132 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 L 62 2x43 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 L 62 2x43 s5s6 I 67 N.s5s6.08
Van-der-waals C-term T 302 - S6 D 74 N.S6.04
Hydrophobic TM7 L 272 7x56 s5s6 I 67 N.s5s6.08
Polar C-term D 292 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term D 292 - s5s6 D 63 N.s5s6.04
Van-der-waals C-term D 292 - s5s6 D 63 N.s5s6.04
Polar C-term G 291 - s5s6 L 64 N.s5s6.05
Ionic C-term D 292 - s5s6 R 61 N.s5s6.02
Polar C-term D 292 - s5s6 R 61 N.s5s6.02
Hydrophobic C-term D 292 - s5s6 R 61 N.s5s6.02
Van-der-waals C-term D 292 - s5s6 R 61 N.s5s6.02
Polar C-term V 308 - S6 L 75 N.S6.05
Polar C-term R 300 - S10 Y 160 N.S10.01
Aromatic C-term R 300 - S10 Y 160 N.S10.01
Hydrophobic C-term R 300 - S10 Y 160 N.S10.01
Van-der-waals C-term R 300 - S10 Y 160 N.S10.01
Ionic C-term E 295 - s17s18 K 289 C.s17s18.18
Polar C-term E 295 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term E 295 - s17s18 K 289 C.s17s18.18
Hydrophobic C-term L 290 - s5s6 I 67 N.s5s6.08
Polar ICL2 S 132 34x54 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 S 132 34x54 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 S 132 34x54 s15s16 L 243 C.s15s16.05
Hydrophobic ICL1 R 55 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 R 55 - s5s6 R 61 N.s5s6.02
Ionic C-term R 304 - s9s10 E 152 N.s9s10.07
Polar C-term R 304 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term R 304 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term R 304 - s9s10 E 152 N.s9s10.07
Polar ICL1 R 55 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL1 R 55 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL1 R 55 - s8s9 D 132 N.s8s9.06
Polar C-term A 294 - s5s6 D 62 N.s5s6.03
Hydrophobic C-term A 294 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term A 294 - s5s6 D 62 N.s5s6.03
Hydrophobic TM2 F 58 2x39 s5s6 L 69 N.s5s6.10
Polar ICL2 A 129 34x51 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 A 129 34x51 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 A 129 34x51 s17s18 E 310 C.s17s18.39
Polar C-term R 300 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term R 300 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term R 300 - s9s10 K 157 N.s9s10.12
Ionic ICL3 R 209 - S6 D 74 N.S6.04
Polar ICL3 R 209 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 209 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 209 - S6 D 74 N.S6.04
Hydrophobic C-term G 306 - S6 D 74 N.S6.04
Van-der-waals C-term G 306 - S6 D 74 N.S6.04
Polar C-term R 304 - s9s10 T 154 N.s9s10.09
Hydrophobic C-term R 304 - s9s10 T 154 N.s9s10.09
Van-der-waals C-term R 304 - s9s10 T 154 N.s9s10.09
Polar C-term E 293 - s5s6 D 62 N.s5s6.03
Hydrophobic C-term E 293 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term E 293 - s5s6 D 62 N.s5s6.03
Polar ICL1 R 55 - s8s9 G 129 N.s8s9.03
Van-der-waals ICL1 R 55 - s8s9 G 129 N.s8s9.03
Polar C-term E 293 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term E 293 - s5s6 D 63 N.s5s6.04
Van-der-waals C-term E 293 - s5s6 D 63 N.s5s6.04
Polar C-term R 300 - s9s10 V 155 N.s9s10.10
Hydrophobic C-term R 300 - s9s10 V 155 N.s9s10.10
Van-der-waals C-term R 300 - s9s10 V 155 N.s9s10.10
Hydrophobic TM3 Q 121 3x50 s5s6 L 69 N.s5s6.10
Hydrophobic C-term A 289 - s5s6 V 66 N.s5s6.07
Van-der-waals C-term A 289 - s5s6 V 66 N.s5s6.07
Hydrophobic C-term V 308 - S6 K 73 N.S6.03
Hydrophobic C-term S 303 - S9 E 142 N.S9.06
Polar ICL2 S 132 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 S 132 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 S 132 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic C-term S 303 - S5 M 52 N.S5.05
Van-der-waals C-term S 303 - S5 M 52 N.S5.05
Hydrophobic C-term I 310 - S6 L 75 N.S6.05
Van-der-waals C-term I 310 - S6 L 75 N.S6.05
Polar ICL1 R 55 - s8s9 P 130 N.s8s9.04
Hydrophobic ICL1 R 55 - s8s9 P 130 N.s8s9.04
Van-der-waals ICL1 R 55 - s8s9 P 130 N.s8s9.04
Hydrophobic C-term I 310 - s7s8 L 120 N.s7s8.06
Van-der-waals C-term I 310 - s7s8 L 120 N.s7s8.06
Hydrophobic C-term A 294 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term A 294 - s5s6 E 65 N.s5s6.06
Hydrophobic H8 G 273 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 273 8x47 s5s6 V 66 N.s5s6.07
Polar TM4 R 137 4x39 S16 K 245 C.S16.02
Van-der-waals C-term R 300 - s9s10 D 159 N.s9s10.14
Polar C-term A 298 - S10 R 162 N.S10.03
Van-der-waals C-term A 298 - S10 R 162 N.S10.03
Polar C-term R 304 - s9s10 E 153 N.s9s10.08
Hydrophobic C-term R 304 - s9s10 E 153 N.s9s10.08
Van-der-waals C-term R 304 - s9s10 E 153 N.s9s10.08
Hydrophobic C-term D 292 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term D 292 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 R 55 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 R 55 - s8s9 A 133 N.s8s9.07
Hydrophobic TM7 Y 269 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 269 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic H8 Q 287 8x61 s5s6 D 63 N.s5s6.04
Van-der-waals H8 Q 287 8x61 s5s6 D 63 N.s5s6.04
Polar ICL1 R 55 - s8s9 G 134 N.s8s9.08
Hydrophobic ICL1 R 55 - s8s9 G 134 N.s8s9.08
Van-der-waals ICL1 R 55 - s8s9 G 134 N.s8s9.08
Polar C-term R 288 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term R 288 - s5s6 D 63 N.s5s6.04
Van-der-waals C-term R 288 - s5s6 D 63 N.s5s6.04
Hydrophobic C-term G 306 - S6 V 77 N.S6.07
Van-der-waals C-term G 306 - S6 V 77 N.S6.07
Hydrophobic H8 Q 276 8x50 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 276 8x50 s5s6 E 65 N.s5s6.06
Polar C-term R 300 - S9 K 144 N.S9.08
Van-der-waals C-term R 300 - S9 K 144 N.S9.08
Polar C-term V 299 - S10 R 162 N.S10.03
Hydrophobic C-term V 299 - S10 R 162 N.S10.03
Van-der-waals C-term V 299 - S10 R 162 N.S10.03
Hydrophobic C-term L 290 - s5s6 L 64 N.s5s6.05
Van-der-waals C-term L 290 - s5s6 L 64 N.s5s6.05
Hydrophobic C-term R 288 - s5s6 V 66 N.s5s6.07
Van-der-waals C-term R 288 - s5s6 V 66 N.s5s6.07
Ionic C-term E 295 - s17s18 K 291 C.s17s18.20
Polar C-term E 295 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term E 295 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term E 295 - s17s18 K 291 C.s17s18.20
Hydrophobic TM6 F 215 6x33 s5s6 G 68 N.s5s6.09
Polar C-term S 303 - S9 K 144 N.S9.08
Hydrophobic C-term S 303 - S9 K 144 N.S9.08
Van-der-waals C-term S 303 - S9 K 144 N.S9.08
Hydrophobic C-term A 289 - s5s6 D 63 N.s5s6.04
Polar C-term R 300 - s9s10 S 156 N.s9s10.11
Hydrophobic C-term R 300 - s9s10 S 156 N.s9s10.11
Van-der-waals C-term R 300 - s9s10 S 156 N.s9s10.11
Hydrophobic TM7 L 272 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 L 272 7x56 s5s6 V 66 N.s5s6.07