Beta-arrestin-1 - MRGPRF complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
MRGPRF 62.2
Beta-arrestin-1 78.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term R 312 - s5s6 V 70 N.s5s6.07
Van-der-waals C-term R 312 - s5s6 V 70 N.s5s6.07
Van-der-waals C-term M 333 - s8s9 T 136 N.s8s9.07
Polar C-term R 315 - s8s9 A 139 N.s8s9.10
Van-der-waals C-term R 315 - s8s9 A 139 N.s8s9.10
Hydrophobic TM6 L 237 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 237 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 L 237 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic C-term A 318 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term A 318 - s15s16 F 244 C.s15s16.03
Polar C-term T 332 - S16 Q 248 C.S16.02
Hydrophobic C-term T 332 - S16 Q 248 C.S16.02
Van-der-waals C-term T 332 - S16 Q 248 C.S16.02
Hydrophobic H8 V 308 8x60 s5s6 L 68 N.s5s6.05
Van-der-waals H8 V 308 8x60 s5s6 L 68 N.s5s6.05
Ionic ICL2 R 153 34x55 s17s18 E 313 C.s17s18.39
Polar ICL2 R 153 34x55 s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 R 153 34x55 s17s18 E 313 C.s17s18.39
Hydrophobic C-term R 315 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term R 315 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term R 315 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term R 315 - s5s6 L 73 N.s5s6.10
Polar TM1 S 72 1x60 s5s6 R 65 N.s5s6.02
Polar H8 R 301 8x53 s20c E 405 C.s20c.15
Van-der-waals H8 R 301 8x53 s20c E 405 C.s20c.15
Ionic C-term E 334 - S16 K 250 C.S16.04
Polar C-term E 334 - S16 K 250 C.S16.04
Hydrophobic C-term E 334 - S16 K 250 C.S16.04
Van-der-waals C-term E 334 - S16 K 250 C.S16.04
Van-der-waals C-term R 315 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term M 333 - S16 A 247 C.S16.01
Hydrophobic ICL1 K 74 - s8s9 T 136 N.s8s9.07
Polar H8 S 299 8x51 s9s10 K 160 N.s9s10.12
Hydrophobic H8 S 299 8x51 s9s10 K 160 N.s9s10.12
Van-der-waals H8 S 299 8x51 s9s10 K 160 N.s9s10.12
Hydrophobic H8 R 296 8x48 s5s6 V 70 N.s5s6.07
Van-der-waals H8 R 296 8x48 s5s6 V 70 N.s5s6.07
Hydrophobic C-term M 335 - S16 Y 249 C.S16.03
Van-der-waals C-term M 335 - S16 Y 249 C.S16.03
Polar C-term D 316 - s5s6 G 72 N.s5s6.09
Hydrophobic C-term D 316 - s5s6 G 72 N.s5s6.09
Van-der-waals C-term D 316 - s5s6 G 72 N.s5s6.09
Polar C-term D 316 - s5s6 L 73 N.s5s6.10
Hydrophobic C-term D 316 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term D 316 - s5s6 L 73 N.s5s6.10
Polar ICL3 R 231 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 231 - S6 D 78 N.S6.04
Hydrophobic C-term L 314 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term L 314 - s5s6 L 73 N.s5s6.10
Polar ICL1 K 74 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 K 74 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 K 74 - s8s9 E 134 N.s8s9.05
Polar ICL1 K 74 - s8s9 G 132 N.s8s9.03
Hydrophobic ICL1 K 74 - s8s9 G 132 N.s8s9.03
Van-der-waals ICL1 K 74 - s8s9 G 132 N.s8s9.03
Hydrophobic C-term T 330 - S16 Q 248 C.S16.02
Van-der-waals C-term T 330 - S16 Q 248 C.S16.02
Hydrophobic C-term M 335 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term M 335 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 R 231 - S6 K 77 N.S6.03
Hydrophobic C-term Q 311 - s5s6 L 68 N.s5s6.05
Van-der-waals C-term Q 311 - s5s6 L 68 N.s5s6.05
Polar C-term R 312 - s5s6 L 71 N.s5s6.08
Hydrophobic C-term R 312 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term R 312 - s5s6 L 71 N.s5s6.08
Polar C-term N 329 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term L 320 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term L 320 - s15s16 F 244 C.s15s16.03
Ionic ICL3 R 233 - S6 D 78 N.S6.04
Polar ICL3 R 233 - S6 D 78 N.S6.04
Hydrophobic ICL3 R 233 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 233 - S6 D 78 N.S6.04
Hydrophobic H8 G 295 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 W 152 34x54 s15s16 F 244 C.s15s16.03
Aromatic ICL2 W 152 34x54 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 W 152 34x54 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 W 152 34x54 s15s16 F 244 C.s15s16.03
Polar C-term V 331 - S16 Q 248 C.S16.02
Hydrophobic C-term V 331 - S16 Q 248 C.S16.02
Van-der-waals C-term V 331 - S16 Q 248 C.S16.02
Hydrophobic TM2 N 76 2x37 s8s9 K 138 N.s8s9.09
Hydrophobic C-term A 313 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term A 313 - s5s6 L 73 N.s5s6.10
Hydrophobic C-term D 316 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term D 316 - s5s6 L 71 N.s5s6.08
Hydrophobic TM7 A 294 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 A 294 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 Y 291 7x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 Y 291 7x53 s5s6 L 71 N.s5s6.08
Polar C-term Q 311 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term Q 311 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term Q 311 - s8s9 K 138 N.s8s9.09
Polar C-term R 312 - s5s6 D 67 N.s5s6.04
Hydrophobic C-term R 312 - s5s6 D 67 N.s5s6.04
Van-der-waals C-term R 312 - s5s6 D 67 N.s5s6.04
Polar ICL1 K 74 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL1 K 74 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL1 K 74 - s8s9 D 135 N.s8s9.06
Hydrophobic C-term R 312 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term R 312 - s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 W 152 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 W 152 34x54 s15s16 N 245 C.s15s16.04
Polar C-term R 315 - s5s6 G 64 N.s5s6.01
Hydrophobic C-term R 315 - s5s6 G 64 N.s5s6.01
Van-der-waals C-term R 315 - s5s6 G 64 N.s5s6.01
Hydrophobic TM6 V 240 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 240 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term T 332 - S16 K 250 C.S16.04
Hydrophobic C-term E 319 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term E 319 - s15s16 F 244 C.s15s16.03
Hydrophobic H8 Q 300 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 Q 300 8x52 s20c E 405 C.s20c.15
Hydrophobic C-term A 313 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term A 313 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term M 335 - S16 K 250 C.S16.04
Van-der-waals TM2 N 76 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic H8 V 308 8x60 s5s6 D 67 N.s5s6.04
Van-der-waals H8 V 308 8x60 s5s6 D 67 N.s5s6.04
Polar C-term E 319 - S6 F 75 N.S6.01
Hydrophobic C-term E 319 - S6 F 75 N.S6.01
Van-der-waals C-term E 319 - S6 F 75 N.S6.01
Hydrophobic C-term R 312 - s5s6 L 68 N.s5s6.05
Van-der-waals C-term R 312 - s5s6 L 68 N.s5s6.05
Polar C-term C 337 - S16 C 251 C.S16.05
Hydrophobic C-term C 337 - S16 C 251 C.S16.05
Van-der-waals C-term C 337 - S16 C 251 C.S16.05
Polar ICL3 R 233 - S5 T 58 N.S5.07
Hydrophobic ICL3 R 233 - S5 T 58 N.S5.07
Van-der-waals ICL3 R 233 - S5 T 58 N.S5.07
Polar ICL1 K 74 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL1 K 74 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 K 74 - s8s9 P 133 N.s8s9.04
Hydrophobic C-term C 337 - S16 P 252 C.S16.06
Hydrophobic C-term R 312 - s5s6 D 69 N.s5s6.06
Van-der-waals C-term R 312 - s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 W 152 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL3 R 233 - S6 R 76 N.S6.02
Van-der-waals ICL3 R 233 - S6 R 76 N.S6.02
Hydrophobic C-term Q 311 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term Q 311 - s5s6 L 73 N.s5s6.10
Polar C-term R 315 - S5 Y 63 N.S5.12
Aromatic C-term R 315 - S5 Y 63 N.S5.12
Hydrophobic C-term R 315 - S5 Y 63 N.S5.12
Van-der-waals C-term R 315 - S5 Y 63 N.S5.12
Polar C-term R 315 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term R 315 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term R 315 - s8s9 K 138 N.s8s9.09
Hydrophobic H8 G 295 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 G 295 8x47 s5s6 L 71 N.s5s6.08
Polar C-term Q 311 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term Q 311 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term Q 311 - s5s6 R 65 N.s5s6.02
Polar C-term C 337 - s17s18 R 285 C.s17s18.11
Polar TM7 A 294 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 A 294 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 A 294 7x56 s5s6 L 71 N.s5s6.08
Polar C-term M 333 - S16 Q 248 C.S16.02
Hydrophobic C-term M 333 - S16 Q 248 C.S16.02
Van-der-waals C-term M 333 - S16 Q 248 C.S16.02
Hydrophobic H8 D 297 8x49 s5s6 V 70 N.s5s6.07
Van-der-waals H8 D 297 8x49 s5s6 V 70 N.s5s6.07