Beta-arrestin-1 - MC1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC1 77.4
Beta-arrestin-1 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 243 6x37 s5s6 L 71 N.s5s6.08
Polar TM5 R 213 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 213 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 213 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 M 210 5x61 s5s6 L 71 N.s5s6.08
Ionic TM5 H 225 5x76 S6 D 78 N.S6.04
Polar TM5 H 225 5x76 S6 D 78 N.S6.04
Hydrophobic TM5 H 225 5x76 S6 D 78 N.S6.04
Van-der-waals TM5 H 225 5x76 S6 D 78 N.S6.04
Hydrophobic TM5 A 214 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 214 5x65 s5s6 L 73 N.s5s6.10
Polar ICL2 L 150 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 150 34x51 S5 Y 63 N.S5.12
Hydrophobic TM2 M 73 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 M 73 2x39 s5s6 D 67 N.s5s6.04
Polar ICL3 Q 228 - S6 V 81 N.S6.07
Van-der-waals TM3 Y 148 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 A 214 5x65 S6 F 75 N.S6.01
Ionic H8 R 307 8x52 s20c E 407 C.s20c.17
Polar H8 R 307 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 R 307 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 R 307 8x52 s20c E 407 C.s20c.17
Hydrophobic TM6 L 246 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 224 5x75 S6 L 79 N.S6.05
Aromatic TM5 H 217 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 217 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 217 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 I 146 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 146 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 224 5x75 S6 D 78 N.S6.04
Van-der-waals TM5 L 224 5x75 S6 D 78 N.S6.04
Polar TM3 I 146 3x54 S5 Y 63 N.S5.12
Hydrophobic TM3 I 146 3x54 S5 Y 63 N.S5.12
Van-der-waals TM3 I 146 3x54 S5 Y 63 N.S5.12
Ionic ICL3 R 229 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 229 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 R 229 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 229 - s9s10 E 155 N.s9s10.07
Hydrophobic TM3 S 145 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 S 145 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 150 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 150 34x51 S8 L 129 N.S8.03
Hydrophobic TM3 R 142 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 146 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 146 3x54 S6 F 75 N.S6.01
Polar ICL2 Y 152 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Y 152 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 152 34x53 s5s6 R 65 N.s5s6.02
Polar TM2 S 71 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 150 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 150 34x51 S16 A 247 C.S16.01
Polar ICL2 A 149 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 149 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 149 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 I 221 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 I 221 5x72 S6 R 76 N.S6.02
Polar ICL3 Q 228 - S6 N 83 N.S6.09
Van-der-waals ICL3 Q 228 - S6 N 83 N.S6.09
Ionic ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM6 T 242 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 242 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 H 225 5x76 S6 V 81 N.S6.07
Van-der-waals TM5 H 225 5x76 S6 V 81 N.S6.07
Ionic TM7 H 301 7x56 s5s6 D 69 N.s5s6.06
Polar TM7 H 301 7x56 s5s6 D 69 N.s5s6.06
Hydrophobic TM7 H 301 7x56 s5s6 D 69 N.s5s6.06
Van-der-waals TM7 H 301 7x56 s5s6 D 69 N.s5s6.06
Aromatic TM5 H 217 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 H 217 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 H 217 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 Y 207 5x58 s5s6 L 71 N.s5s6.08
Polar TM3 F 147 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 F 147 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 F 147 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 L 150 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 150 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 150 34x51 S16 Y 249 C.S16.03
Polar ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 224 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 L 224 5x75 S6 K 77 N.S6.03
Hydrophobic TM7 H 301 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 H 301 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 G 239 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 142 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 221 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 I 221 5x72 S6 K 77 N.S6.03
Polar ICL2 R 151 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 151 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 151 34x52 S16 Y 249 C.S16.03
Polar TM6 T 242 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 242 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 G 220 5x71 S6 K 77 N.S6.03
Hydrophobic ICL2 L 150 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 150 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 L 150 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 L 150 34x51 S9 C 140 N.S9.01
Hydrophobic TM7 I 297 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 I 297 7x52 s5s6 V 70 N.s5s6.07