Arrestin-C - motilin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
motilin 72.4
Arrestin-C 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 18.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM4 R 152 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 R 152 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 R 152 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 T 296 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 296 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 140 3x54 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 A 285 - S6 D 74 N.S6.04
Van-der-waals ICL3 A 285 - S6 D 74 N.S6.04
Hydrophobic TM3 R 136 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 136 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 V 150 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 150 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 H 293 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 R 142 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 144 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 144 34x51 S15 V 238 C.S15.14
Hydrophobic TM5 L 281 5x72 S6 K 73 N.S6.03
Ionic ICL2 R 145 34x52 S16 D 244 C.S16.01
Polar ICL2 R 145 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 145 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 145 34x52 S16 D 244 C.S16.01
Hydrophobic TM7 I 358 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 I 358 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 143 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 A 139 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 139 3x53 S6 F 71 N.S6.01
Polar ICL2 R 145 34x52 S16 Y 246 C.S16.03
Polar TM2 T 73 2x39 s5s6 D 63 N.s5s6.04
Polar TM6 R 289 6x26 S6 R 72 N.S6.02
Hydrophobic TM6 R 289 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 R 289 6x26 S6 R 72 N.S6.02
Polar ICL2 R 147 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 L 300 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 300 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 143 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 143 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL3 P 284 - S6 V 77 N.S6.07
Hydrophobic TM3 I 140 3x54 S6 F 71 N.S6.01
Hydrophobic ICL2 L 144 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 144 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 R 147 34x54 S9 C 137 N.S9.01
Van-der-waals ICL2 R 147 34x54 S9 C 137 N.S9.01
Polar ICL2 L 144 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 144 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 144 34x51 S16 Y 246 C.S16.03
Hydrophobic TM3 I 140 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 140 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 V 148 34x55 S16 Y 246 C.S16.03
Hydrophobic ICL2 R 147 34x54 s8s9 P 136 N.s8s9.10
Van-der-waals ICL2 R 147 34x54 s8s9 P 136 N.s8s9.10
Polar TM4 R 153 4x40 s8s9 E 131 N.s8s9.05
Hydrophobic TM7 I 358 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 E 135 3x49 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 E 135 3x49 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 144 34x51 S9 C 137 N.S9.01
Hydrophobic TM5 L 274 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 R 289 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 R 289 6x26 S6 K 73 N.S6.03
Ionic H8 K 368 8x56 s20c E 386 C.s20c.20
Polar H8 K 368 8x56 s20c E 386 C.s20c.20
Van-der-waals H8 K 368 8x56 s20c E 386 C.s20c.20
Hydrophobic ICL2 V 148 34x55 s17s18 R 282 C.s17s18.11
Polar ICL2 R 147 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 147 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 147 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 S 277 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 277 5x68 s15s16 Y 241 C.s15s16.03
Polar TM6 R 289 6x26 S5 Y 59 N.S5.12
Van-der-waals TM6 R 289 6x26 S5 Y 59 N.S5.12
Polar ICL2 R 147 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 R 147 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 R 147 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 L 144 34x51 S8 L 126 N.S8.03
Polar ICL2 R 147 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 R 147 34x54 S5 Y 59 N.S5.12
Polar H8 K 361 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 361 8x49 s5s6 D 62 N.s5s6.03
Polar TM2 T 71 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 71 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 71 2x37 s5s6 D 63 N.s5s6.04
Polar ICL2 R 147 34x54 s5s6 G 60 N.s5s6.01
Van-der-waals ICL2 R 147 34x54 s5s6 G 60 N.s5s6.01
Ionic H8 K 361 8x49 s5s6 E 65 N.s5s6.06
Polar H8 K 361 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 K 361 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 361 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 A 139 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 139 3x53 s5s6 L 64 N.s5s6.05
Polar TM6 T 296 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 296 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 296 6x33 s5s6 I 67 N.s5s6.08
Polar TM6 R 289 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 R 289 6x26 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 R 289 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 V 299 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 V 299 6x36 s5s6 I 67 N.s5s6.08