S-arrestin - MT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MT1 81.8
S-arrestin 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 133 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 133 34x51 S16 Y 259 C.S16.03
Hydrophobic TM6 P 227 6x24 S6 D 86 N.S6.04
Van-der-waals TM6 P 227 6x24 S6 D 86 N.S6.04
Polar TM3 I 129 3x54 S5 Y 71 N.S5.12
Hydrophobic TM3 I 129 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 I 129 3x54 S5 Y 71 N.S5.12
Polar TM5 V 217 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 V 217 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 V 217 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 V 221 5x72 S6 L 87 N.S6.05
Hydrophobic TM3 Y 128 3x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 L 58 12x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 L 133 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 133 34x51 S8 L 136 N.S8.03
Polar TM5 R 220 5x71 s15s16 V 252 C.s15s16.01
Van-der-waals TM5 R 220 5x71 s15s16 V 252 C.s15s16.01
Polar TM6 D 233 6x30 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 D 233 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 D 233 6x30 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 D 233 6x30 s5s6 G 80 N.s5s6.09
Polar TM6 N 236 6x33 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 N 236 6x33 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 133 34x51 S15 V 251 C.S15.14
Polar ICL2 D 136 34x54 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 L 133 34x51 S9 C 147 N.S9.01
Hydrophobic TM2 N 60 2x37 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 60 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 V 217 5x68 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 V 217 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 L 133 34x51 S5 Y 71 N.S5.12
Hydrophobic TM6 N 236 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 N 236 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 I 129 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 129 3x54 S6 F 83 N.S6.01
Hydrophobic TM3 Y 128 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 Y 128 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 R 225 - S6 F 89 N.S6.07
Hydrophobic TM5 L 213 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 L 213 5x64 s15s16 Y 254 C.s15s16.03
Polar TM3 Y 128 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 Y 128 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 Y 128 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 V 221 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 V 221 5x72 S6 D 86 N.S6.04
Ionic TM6 K 230 6x27 s9s10 E 165 N.s9s10.07
Van-der-waals ICL1 K 57 12x49 s5s6 V 78 N.s5s6.07
Ionic ICL2 D 136 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 D 136 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 D 136 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 D 136 34x54 s8s9 K 145 N.s8s9.09
Polar TM5 R 220 5x71 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 R 220 5x71 s15s16 L 253 C.s15s16.02
Hydrophobic TM3 R 125 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 125 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 221 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 V 221 5x72 S6 R 85 N.S6.03
Polar TM3 Y 128 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 Y 128 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 Y 128 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 Y 135 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 135 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 V 217 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 V 217 5x68 s15s16 Y 254 C.s15s16.03
Polar H8 N 299 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 299 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 N 63 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 63 2x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 V 214 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 I 129 3x54 s5s6 I 79 N.s5s6.08
Polar TM5 R 220 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 R 220 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 R 220 5x71 S6 R 85 N.S6.03
Hydrophobic TM6 N 236 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 N 236 6x33 s5s6 I 79 N.s5s6.08
Polar H8 N 301 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 301 8x49 s5s6 D 77 N.s5s6.06
Polar TM6 F 237 6x34 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 F 237 6x34 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 F 237 6x34 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 D 136 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 D 136 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 S 132 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 S 132 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 S 132 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 F 237 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 F 237 6x34 s5s6 L 81 N.s5s6.10
Polar ICL2 S 132 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 132 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 132 34x50 s8s9 K 145 N.s8s9.09
Ionic TM6 K 230 6x27 s9s10 D 166 N.s9s10.08
Polar TM6 K 230 6x27 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 230 6x27 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 230 6x27 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 I 129 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 129 3x54 s5s6 L 81 N.s5s6.10
Polar TM5 R 220 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 R 220 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 R 220 5x71 s17s18 T 323 C.s17s18.39