Beta-arrestin-1 - MT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MT2 79.1
Beta-arrestin-1 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 145 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 S 145 34x50 S5 Y 63 N.S5.12
Hydrophobic H8 F 315 8x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 141 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 Y 141 3x53 s5s6 R 65 N.s5s6.02
Polar TM6 D 246 6x30 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 D 246 6x30 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 D 246 6x30 s5s6 G 72 N.s5s6.09
Hydrophobic ICL3 S 238 - S6 D 78 N.S6.04
Van-der-waals ICL3 S 238 - S6 D 78 N.S6.04
Hydrophobic H8 N 312 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 312 8x47 s5s6 V 70 N.s5s6.07
Polar TM3 Y 141 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 Y 141 3x53 s5s6 D 67 N.s5s6.04
Polar ICL1 K 70 12x49 s20c K 403 C.s20c.13
Polar TM3 C 143 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 143 3x55 s15s16 N 245 C.s15s16.04
Polar TM2 N 73 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 73 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 73 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 L 79 2x43 s5s6 V 70 N.s5s6.07
Polar TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 146 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 M 146 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 L 240 6x24 S6 F 75 N.S6.01
Hydrophobic TM5 L 226 5x64 s15s16 F 244 C.s15s16.03
Ionic ICL2 H 149 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 H 149 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 149 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 149 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 S 238 - S6 K 77 N.S6.03
Van-der-waals ICL3 S 238 - S6 K 77 N.S6.03
Hydrophobic TM3 R 138 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 138 3x50 s5s6 L 71 N.s5s6.08
Polar TM6 S 249 6x33 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 S 249 6x33 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 S 249 6x33 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 S 249 6x33 s5s6 L 71 N.s5s6.08
Polar TM5 K 233 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 K 233 5x71 S6 K 77 N.S6.03
Hydrophobic TM6 M 253 6x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 253 6x37 s5s6 V 70 N.s5s6.07
Polar ICL2 S 145 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 V 227 5x65 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 A 230 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 A 230 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 A 234 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 A 234 5x72 S6 K 77 N.S6.03
Hydrophobic TM2 N 76 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 N 76 2x40 s5s6 V 70 N.s5s6.07
Polar TM6 F 250 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 F 250 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 250 6x34 s5s6 L 71 N.s5s6.08
Polar TM3 I 142 3x54 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 142 3x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 S 249 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 S 249 6x33 s5s6 G 72 N.s5s6.09
Ionic H8 R 317 8x52 s20c E 407 C.s20c.17
Polar H8 R 317 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 R 317 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 R 317 8x52 s20c E 407 C.s20c.17
Hydrophobic TM6 L 242 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 M 146 34x51 S16 Q 248 C.S16.02
Van-der-waals ICL2 M 146 34x51 S16 Q 248 C.S16.02
Polar TM6 F 250 6x34 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 146 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 M 146 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 S 249 6x33 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 S 249 6x33 s5s6 V 70 N.s5s6.07
Polar TM6 C 241 6x25 S6 R 76 N.S6.02
Hydrophobic TM3 I 142 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 142 3x54 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 70 12x49 s20c E 405 C.s20c.15
Polar ICL1 K 70 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 K 70 12x49 s20c E 405 C.s20c.15
Ionic TM5 K 233 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 K 233 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 K 233 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 K 233 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 F 250 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 F 250 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 142 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 240 6x24 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 L 242 6x26 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 242 6x26 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 242 6x26 S6 F 75 N.S6.01
Van-der-waals TM6 L 242 6x26 S6 F 75 N.S6.01
Polar ICL2 H 149 34x54 s17s18 R 285 C.s17s18.11
Hydrophobic TM5 V 227 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 V 227 5x65 S6 F 75 N.S6.01
Ionic TM4 R 154 4x39 s8s9 E 134 N.s8s9.05
Polar TM4 R 154 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 154 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 154 4x39 s8s9 E 134 N.s8s9.05
Polar ICL2 H 149 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 H 149 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 H 149 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 V 227 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 142 3x54 s5s6 L 68 N.s5s6.05
Polar TM6 D 246 6x30 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 D 246 6x30 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 D 246 6x30 s5s6 L 73 N.s5s6.10
Polar H8 N 314 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 314 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 314 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 L 240 6x24 S6 R 76 N.S6.02
Van-der-waals TM6 L 240 6x24 S6 R 76 N.S6.02
Polar TM3 Y 141 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 Y 141 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 Y 141 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 223 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 Y 141 3x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 Y 141 3x53 s5s6 L 71 N.s5s6.08
Polar H8 N 312 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 312 8x47 s5s6 D 69 N.s5s6.06