Beta-arrestin-1 - NK3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NK3 65.5
Beta-arrestin-1 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 S 196 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 S 196 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 L 191 - S9 C 140 N.S9.01
Van-der-waals ICL2 L 191 - S9 C 140 N.S9.01
Hydrophobic C-term L 385 - s9s10 H 159 N.s9s10.11
Hydrophobic ICL2 P 193 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 P 193 - s8s9 D 135 N.s8s9.06
Hydrophobic TM2 L 124 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 297 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 297 6x33 s5s6 L 71 N.s5s6.08
Polar H8 N 360 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 360 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 274 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 274 5x65 S6 F 75 N.S6.01
Hydrophobic ICL2 P 193 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 193 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term F 392 - s20c E 406 C.s20c.16
Van-der-waals C-term F 392 - s20c E 406 C.s20c.16
Hydrophobic TM6 M 301 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 R 194 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 194 - s8s9 D 135 N.s8s9.06
Hydrophobic TM5 P 280 5x71 s15s16 L 243 C.s15s16.02
Hydrophobic TM3 I 187 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic C-term Y 382 - s9s10 H 159 N.s9s10.11
Hydrophobic C-term F 392 - s20c E 407 C.s20c.17
Van-der-waals C-term F 392 - s20c E 407 C.s20c.17
Polar C-term Q 397 - s20c S 412 C.s20c.22
Hydrophobic C-term Q 397 - s20c S 412 C.s20c.22
Van-der-waals C-term Q 397 - s20c S 412 C.s20c.22
Hydrophobic TM2 T 118 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 191 - S15 I 241 C.S15.14
Van-der-waals ICL2 L 191 - S15 I 241 C.S15.14
Ionic ICL1 R 115 12x49 s5s6 E 66 N.s5s6.03
Polar ICL1 R 115 12x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 L 191 - S16 Y 249 C.S16.03
Van-der-waals ICL2 L 191 - S16 Y 249 C.S16.03
Hydrophobic ICL2 L 191 - S5 Y 63 N.S5.12
Van-der-waals ICL2 L 191 - S5 Y 63 N.S5.12
Polar H8 N 360 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 360 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 360 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 191 - S8 L 129 N.S8.03
Van-der-waals ICL2 L 191 - S8 L 129 N.S8.03
Ionic H8 R 362 8x49 s5s6 D 69 N.s5s6.06
Polar H8 R 362 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 R 362 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 362 8x49 s5s6 D 69 N.s5s6.06
Ionic TM6 K 286 6x22 S6 D 78 N.S6.04
Polar TM6 K 286 6x22 S6 D 78 N.S6.04
Hydrophobic TM6 K 286 6x22 S6 D 78 N.S6.04
Van-der-waals TM6 K 286 6x22 S6 D 78 N.S6.04
Van-der-waals C-term T 389 - s20c E 405 C.s20c.15
Hydrophobic ICL2 P 190 - S5 Y 63 N.S5.12
Van-der-waals ICL2 P 190 - S5 Y 63 N.S5.12
Hydrophobic ICL3 T 283 - S6 V 81 N.S6.07
Polar ICL2 L 191 - s5s6 R 65 N.s5s6.02
Hydrophobic TM6 M 300 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 300 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term V 403 - S20 V 387 C.S20.02
Van-der-waals C-term V 403 - S20 V 387 C.S20.02
Polar TM3 I 188 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 188 3x55 s15s16 N 245 C.s15s16.04
Ionic C-term R 405 - s19s20 D 385 C.s19s20.51
Polar C-term R 405 - s19s20 D 385 C.s19s20.51
Hydrophobic C-term R 405 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term R 405 - s19s20 D 385 C.s19s20.51
Ionic ICL2 R 194 - s5s6 D 67 N.s5s6.04
Polar ICL2 R 194 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 194 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 194 - s5s6 D 67 N.s5s6.04
Polar ICL2 K 192 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 K 192 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 192 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term R 405 - S20 V 387 C.S20.02
Hydrophobic TM6 A 293 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 191 - S16 A 247 C.S16.01
Hydrophobic TM6 K 294 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 294 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 G 281 5x72 S6 K 77 N.S6.03
Hydrophobic TM2 T 120 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 183 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 183 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 294 6x30 S6 F 75 N.S6.01
Hydrophobic TM6 V 297 6x33 s5s6 L 73 N.s5s6.10
Polar TM5 P 280 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 P 280 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 P 280 5x71 S6 K 77 N.S6.03
Hydrophobic TM3 I 187 3x54 S6 F 75 N.S6.01
Polar C-term T 404 - S20 F 388 C.S20.03
Hydrophobic C-term S 381 - s9s10 R 161 N.s9s10.13
Polar C-term M 406 - H1 K 107 N.H1.09
Hydrophobic C-term M 406 - H1 K 107 N.H1.09
Polar TM6 Q 290 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 Q 290 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 Q 290 6x26 S6 R 76 N.S6.02
Hydrophobic C-term F 392 - s20c D 408 C.s20c.18
Van-der-waals C-term F 392 - s20c D 408 C.s20c.18
Polar ICL2 P 190 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 190 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 190 - s5s6 R 65 N.s5s6.02
Ionic H8 R 362 8x49 s5s6 E 66 N.s5s6.03
Polar H8 R 362 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 362 8x49 s5s6 E 66 N.s5s6.03
Polar C-term T 390 - s20c E 405 C.s20c.15
Hydrophobic C-term T 390 - s20c E 405 C.s20c.15
Van-der-waals C-term T 390 - s20c E 405 C.s20c.15
Ionic ICL1 R 115 12x49 s20c E 405 C.s20c.15
Polar ICL1 R 115 12x49 s20c E 405 C.s20c.15
Hydrophobic ICL1 R 115 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 R 115 12x49 s20c E 405 C.s20c.15
Hydrophobic ICL2 R 194 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 194 - s5s6 R 65 N.s5s6.02
Hydrophobic TM5 I 279 5x70 S6 K 77 N.S6.03
Hydrophobic C-term M 406 - S20 F 388 C.S20.03
Hydrophobic TM5 L 274 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 A 186 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 186 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 N 121 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 N 121 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 190 - s5s6 G 64 N.s5s6.01
Hydrophobic TM5 I 279 5x70 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 I 279 5x70 s15s16 F 244 C.s15s16.03
Hydrophobic C-term F 392 - s20c G 409 C.s20c.19
Van-der-waals C-term F 392 - s20c G 409 C.s20c.19
Hydrophobic ICL3 T 283 - S6 D 78 N.S6.04
Hydrophobic TM3 I 187 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 187 3x54 s5s6 L 71 N.s5s6.08