Beta-arrestin-1 - BB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
BB1 73.8
Beta-arrestin-1 82.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 151 34x53 s17s18 G 286 C.s17s18.12
Hydrophobic TM2 N 79 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 N 79 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 L 246 - s15s16 F 244 C.s15s16.03
Hydrophobic TM3 I 145 3x54 s5s6 L 68 N.s5s6.05
Polar C-term L 365 - H1 K 107 N.H1.09
Hydrophobic C-term L 365 - H1 K 107 N.H1.09
Van-der-waals C-term L 365 - H1 K 107 N.H1.09
Polar C-term Y 346 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term Y 346 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term Y 346 - s9s10 R 161 N.s9s10.13
Hydrophobic TM7 L 324 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 324 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 148 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 M 149 34x51 S5 Y 63 N.S5.12
Van-der-waals C-term L 365 - s19s20 D 385 C.s19s20.51
Hydrophobic TM6 T 260 6x29 s5s6 G 72 N.s5s6.09
Polar ICL2 S 154 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 S 154 34x56 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 S 154 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 M 151 34x53 S16 Y 249 C.S16.03
Hydrophobic TM3 R 141 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 141 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL1 A 73 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 A 73 12x49 s20c E 405 C.s20c.15
Hydrophobic C-term L 365 - S20 F 388 C.S20.03
Van-der-waals C-term L 365 - S20 F 388 C.S20.03
Hydrophobic TM6 L 264 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 264 6x33 s5s6 L 71 N.s5s6.08
Polar TM6 E 249 6x18 S6 V 81 N.S6.07
Polar ICL2 Q 152 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 Q 152 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 152 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 A 144 3x53 s5s6 L 68 N.s5s6.05
Polar TM7 L 327 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 R 261 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 M 149 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 M 149 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 M 151 34x53 s8s9 Q 130 N.s8s9.01
Van-der-waals ICL2 M 151 34x53 s8s9 Q 130 N.s8s9.01
Van-der-waals TM6 N 251 6x20 S6 V 81 N.S6.07
Polar ICL2 G 155 34x57 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 G 155 34x57 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 I 82 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 I 82 2x43 s5s6 V 70 N.s5s6.07
Polar TM6 R 261 6x30 S5 Y 63 N.S5.12
Van-der-waals TM6 R 261 6x30 S5 Y 63 N.S5.12
Polar TM6 R 261 6x30 s5s6 T 74 N.s5s6.11
Hydrophobic TM2 P 78 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 P 78 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 Q 152 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 Q 152 34x54 s8s9 D 135 N.s8s9.06
Polar ICL3 P 247 - S6 K 77 N.S6.03
Hydrophobic ICL3 P 247 - S6 K 77 N.S6.03
Van-der-waals ICL3 P 247 - S6 K 77 N.S6.03
Polar TM6 Q 257 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 Q 257 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 Q 257 6x26 S6 R 76 N.S6.02
Hydrophobic ICL2 M 149 34x51 S8 L 129 N.S8.03
Hydrophobic ICL2 M 151 34x53 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 M 151 34x53 s8s9 P 131 N.s8s9.02
Polar ICL2 S 154 34x56 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 S 154 34x56 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 S 154 34x56 s17s18 R 285 C.s17s18.11
Ionic H8 E 329 8x48 s9s10 K 157 N.s9s10.09
Polar H8 E 329 8x48 s9s10 K 157 N.s9s10.09
Van-der-waals H8 E 329 8x48 s9s10 K 157 N.s9s10.09
Polar ICL2 S 154 34x56 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 M 149 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 M 149 34x51 S15 I 241 C.S15.14
Polar ICL2 P 148 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 P 148 34x50 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 P 148 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM5 L 239 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 239 5x65 s5s6 L 73 N.s5s6.10
Polar C-term T 363 - S20 F 388 C.S20.03
Polar ICL2 M 149 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 M 149 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 M 149 34x51 S16 Y 249 C.S16.03
Hydrophobic C-term V 360 - S20 E 389 C.S20.04
Van-der-waals C-term V 360 - S20 E 389 C.S20.04
Hydrophobic TM2 S 76 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 76 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic C-term M 362 - S20 V 387 C.S20.02
Hydrophobic TM3 A 144 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 144 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 145 3x54 S6 F 75 N.S6.01
Van-der-waals ICL2 M 151 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 G 248 - S6 K 77 N.S6.03
Hydrophobic TM6 H 253 6x22 S6 R 76 N.S6.02
Hydrophobic TM6 L 264 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 264 6x33 s5s6 L 73 N.s5s6.10
Polar TM6 Q 257 6x26 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 Q 257 6x26 s5s6 T 74 N.s5s6.11
Polar TM2 V 77 2x38 s5s6 D 67 N.s5s6.04
Ionic TM3 D 140 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 D 140 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 D 140 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 D 140 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 M 149 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic H8 S 328 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic C-term Y 353 - s20c K 403 C.s20c.13
Van-der-waals C-term Y 353 - s20c K 403 C.s20c.13
Polar ICL2 Q 152 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 P 247 - s15s16 L 243 C.s15s16.02
Polar H8 S 328 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 P 78 2x39 s5s6 V 70 N.s5s6.07
Ionic TM6 H 253 6x22 S6 D 78 N.S6.04
Polar TM6 H 253 6x22 S6 D 78 N.S6.04
Van-der-waals TM6 H 253 6x22 S6 D 78 N.S6.04